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    Effects of zinc oxide administrations on body weight gain and some biochemical parameters in lambs
    (Scientific Technical Research Council Turkey, 2002) Aksoy, G; Sahin, T; Çimtay, I; Kaya, NBA
    The aim of this study was to determine the effects of zinc oxide administrations on body weight gain and some biochemical parameters (zinc, copper, iron, calcium, magnesium. total protein and gammaglobulin) in the blood serum of lambs. This study was performed on 35 Ivesi male lambs (control group: 15, experimental group: 20), aged between 20 and 25 days. In the experimental group. 500 mg zinc oxide (296 solution) was administered orally 12 times with period of a week. Blood samples were collected on days of 0, 14, 28, 42 and 84. Furthermore, body weights of the lambs were determined on days of 0, 14, 28. 42, 56, 70, 84 and 118. The mean serum zinc and gammaglobulin levels in all periods after zinc administrations in the experimental group were significantly higher than those in the control group. Also, body weights of the experimental group on days of 70, 84 and 118 were significantly higher than those of the control group. However, copper values in the experimental group were significantly lower on days of 28, 42 and 84 than those in the control group. There were no significant differences in iron, calcium, magnesium and total protein levels between two groups. In conclusion, oral zinc oxide administration caused significant increases in body weight gain and serum zinc and gammaglobulin levels in lambs. Zinc and copper combinations were concluded to be more useful than zinc given alone. Because zinc administration alone might cause decreases in serum copper values of lambs.
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    Öğe
    Risk factors for hepatocellular carcinoma in Turkey
    (Springer, 2001) Uzunalimoglu, Ö; Yurdaydin, C; Çetinkaya, H; Bozkaya, H; Sahin, T; Çolakoglu, S; Tankurt, E
    The contribution of hepatitis B, hepatitis C, and excess alcohol intake to the development of hepatocellular carcinoma in Turkey was assessed. The study was conducted through a questionnaire sent to seven major medical referral centers in different regions of Turkey and is based on 207 patients seen in the period 1994-1997. Of the seven centers, two were located in West Turkey (54 patients), two were in Central Turkey (85 patients), and two were in south and southeast Turkey (68 patients). In 196 of the 207 patients (94.7%), there was a history of chronic liver disease, and in 180 patients (87%) liver cirrhosis was documented, Of the 207 patients, 116 (56%) had hepatitis B, 48 (23.2%) had hepatitis C and 33 (15.9%) had a history of excess alcohol intake. Anti-delta testing was available in 69 of 116 patients with hepatitis B, and anti-HDV was positive in 13 of these patients (13/69, 18.8%). Of the 33 patients with a history of heavy alcohol intake, 18 had concomitant chronic viral hepatitis infection, and alcohol alone was the etiology of hepatocellular carcinoma in only 15 cases (7.2%). The distribution of etiologic factors was not homogenous in different geographical regions ill Turkey. In central, south, and southeastern Turkey, the predominant etiology of hepatocellular carcinoma was hepatitis B, whereas in western Turkey the impact of hepatitis B, hepatitis C, and alcohol was similar. This study indicates that hepatitis B virus infection is the leading cause of hepatocellular carcinoma in Turkey, followed by hepatitis C infection and alcoholic liver disease.