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    Circulating resistin is elevated in patients with non-alcoholic fatty liver disease and is associated with steatosis, portal inflammation, insulin resistance and nonalcoholic steatohepatitis scores
    (Edizioni Minerva Medica, 2012) Senates, E.; Colak, Y.; Yesil, A.; Coskunpinar, E.; Sahin, O.; Kahraman, O. T.; Senates, B. Erkalma
    Aim. We aimed to investigate the association between serum levels of resistin and the biochemical and histological features of patients with nonalcoholic fatty liver disease (NAFLD) to determine the usefulness of this relationship in the clinical practice. Methods. A total of 97 patients with NAFLD and 66 age- and sex-matched healthy controls were recruited. Detailed epidemiological, anthropometric and laboratory data were recorded. Serum levels of resistin were measured with ELISA. Results. Serum levels of resistin were significantly higher in patients with NAFLD (32.10 +/- 10.0 ng/mL and 26.57 +/- 13.60 ng/mL, respectively) compared with healthy controls (P=0.003). Serum resistin levels were associated with AST, ALT, HOMA-IR, histological steatosis, portal inflammation and nonalcoholic steatohepatitis (NASH) scores. The serum levels of resistin were significantly higher in patients with definite NASH compared to patients with simple steatosis (29 +/- 13 and 20 +/- 10 ng/mL, respectively, P=0.03). There was no association between the serum resistin levels and the liver fibrosis stages. Conclusion. Our data suggest that resistin levels are elevated in patients with NAFLD and could discriminate simple steatosis from definite NASH.
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    SYNTHESIS OF ACTIVATED CARBON IN THE PRESENCE OF HYDROCHAR FROM CHICKPEA STALK AND ITS CHARACTERIZATION
    (Natl Inst R&D Materials Physics, 2021) Genli, N.; Sahin, O.; Baytar, O.; Horoz, S.
    In this study, hydrochar was obtained from chickpea stalk by hydrothermal method. Then, activated carbon was synthesized by chemical activation method using ZnCl2 activator in the presence of this hydrochar. The effects of parameters such as impragnation rate (hydrochar/ZnCl2), impragnation rate, activation temperature and activation time on activated carbon synthesis were investigated. The iodine number of the obtained activated carbon was determined and its characterization was performed by SEM, BET, FTIR measurements. It was determined that the highest iodine number of synthesized activated carbon was 734 mg/g under conditions of impragnation time (24 hour), impragnation rate (1/2), activation temperature (400 degrees C), and activation time (45 minutes). The BET surface area of the activated carbon with the highest iodine number was determined as 572 m(2)/g. The methylene blue number of synthesized activated carbon and hydrochar were found as 105 mg/g and 45 mg/g, respectively.