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    Impact of the arginine silicate inositol complex on bone metabolism in broiler chickens with tibial dyschondroplasia caused by manganese deficiency
    (Taylor & Francis Ltd, 2024) Sahin, E.; Ipcak, H. H.; Orhan, C.; Denli, M.; Erten, F.; Ozercan, I. H.; Balci, T. A.
    1. Tibial dyschondroplasia (TD) is a skeletal disorder in broilers that has financial implications, necessitating dietary modifications to reduce the prevalence of this disease. This study explored how arginine silicate inositol complex (ASI) supplementation affected tibial growth plate (TGP) and overall bone health in broilers with manganese (Mn) deficiency-induced TD. 2. A total of 240 broiler chicks were divided into four groups, each consisting of 60 birds (15 replicates of four broilers each) as follows: i) Control, with 60 mg Mn per kg of diet; ii) ASI, with 60 mg Mn and 1 g ASI per kg of diet; iii) TD, with 22 mg Mn per kg of diet, and iv) TD+ASI, with 22 mg Mn and 1 g ASI per kg of diet. 3. It was found that ASI supplementation increased tibial bone length in Mn-deficient TD broilers (p = 0.007). There was no Mn x ASI interaction for other bone morphometry variables (p > 0.05). However, both tibial bone mineral content and density were affected by Mn and ASI (p < 0.05). With ASI supplementation, serum bone-specific alkaline phosphatase and osteocalcin levels were elevated in the TD+ASI group compared to the TD group (p < 0.001). In the TD group, osteoprotegerin (OPG) levels in the TGP decreased compared to the control groups (p < 0.001). 4. In contrast, ASI supplementation in the TD broilers counteracted the decrease in OPG compared to TD broilers without ASI supplementation (p < 0.001). The Mn level and ASI supplementation significantly influenced the OPG/receptor activator of the nuclear factor-kappa B ligand ratio (p < 0.001). 5. In conclusion, the results demonstrated that inclusion of ASI in broiler diets could enhance bone formation variables by controlling OPG levels in the TGP, potentially serving as an effective method to decrease the occurrence of TD.
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    Synthesis, characterization and effect of the fluorine substitution on the redox reactivity and in vitro anticancer behaviors of N-polyfluorophenyl-3,5-di-tert-butylsalicylaldimines and their Cu(II) complexes
    (Elsevier Science Sa, 2014) Kasumov, V. T.; Suzergoz, F.; Sahin, E.; Celik, O.; Aslanoglu, M.
    A series of new polyfluorinated bis(N-C(6)F(n)H(5-n)3,5-(t)Bu2salicylaidiminato)Cu(11) [n = 2; 2,4-F2C6H3-3,5-DTBS (1), 2,5-F2C6H3-3,5-DTBS (2), 2,6-F2C6H3-3,5-DTBS (3); n = 3; 2,3,4-F3C6H2-3,5-DTBS (4), n= 4; 2,3,5,6-F4C6H-3,5-DTBS (5), n = 5; 2,3,4,5,6-F5C6-3,5-DTBS (6); where 3,5-DTBS is 3,5-(t)Bu(2)salicylaldiminatol with N-polyfluoropheny1-3,5-di-tert-butylsalicylaldi-mines (HL1-HL6) have been synthesized. Their structure, chemical and electrochemical redox-reactivity as well as cytotoxic activity of these compounds were characterized by analytical, spectroscopic (UV/vis, FT-IR, F-19 NMR and EPR), magnetic, CV techniques and MIT assay. The in situ UV/Vis study have shown that the redox behavior of 1-6 and their Cu-phenoxyl radicals (1(center dot+)-6(center dot+) and 1(center dot center dot+)-6(center dot center dot+)) depend on the number and positions of F atoms on the aniline ring as well as of the nature of solvent. The in vitro cytotoxic activity studies of HL1-HL6 and 1-6 against K562 cell lines indicate that the HL1, HL4-HL6 and their corresponding complexes (1, 4-6) exhibited higher cytotoxic activity than HL2, HL3 and their complexes. Compounds 1, 4 and 5 are more cytotoxic than their respective ligands. (C) 2014 Elsevier B.V. All rights reserved.