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    Effects of Malathion in fetal kidney tissues in pregnant rats: Teratogenic effects induced by different doses
    (Veteriner Fakultesi Dergisi, 2012) Alp H.; Sak M.E.; Evsen M.S.; Firat U.; Evliyaoglu O.; Penbegul N.; Sancaktutar, Ahmet Ali
    The aim of this study was to investigate the teratogenic effects of Malathion (ML) induced by different doses on fetal kidney tissues in pregnant rats. A total of 28 Sprague-Dawley pregnant rats were randomly divided into 4 groups of 7 rats each. Depending on ML dose, four groups were formed, including (I) control, (II) ML 2.5 (ML 2.5 mg/kg/day, orally), (III) ML 5 (5 mg/kg/day, orally), and (IV) ML 10 (10 mg/kg/day, orally). ML application started when the male and female were put together (when mating started). Daily ML application was continued until birth. It was determined that in parallel with dose of ML, ML resulted in toxic effects on serum enzymes (acetyl-cholinesterase (AChE), amylase and lipase) and kidney tissues of pregnant rats, and also -regardless of ML dose in fetal kidneys- it led to teratogenic effects in all the doses. Biochemical data wasconfirmed by histopathologic data. We concluded that ML leads to kidney damage in both pregnant and fetal rats as a result of its teratogenic and toxic effects.
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    Tubularized incised plate repair in circumcised adults
    (2013) Hatipoglu N.K.; Bodakci M.N.; Soylemez H.; Sancaktutar, Ahmet Ali; Atar M.; Penbegul N.; Cakmakci S.
    Aim In this study, the experience of tubularized incised plate repair in circumcised adults in terms of functional, cosmetic, and satisfactory results is reported. Methods Tubularized incised plate repair urethroplasty (TIPU) was performed to 27 circumcised adult patients between 2008- 2010; 19 (70.4%) had distal penile hypospadias and eight (29.6%) had midshaft hypospadias. All patients were operated by a single surgeon and were asked to fill out a questionnaire to asses functional and cosmetic results of the surgery. Results The mean age of patients was 22.0 years. All patients were controlled in urology office seven days after the removal of urethral catheter. They were controlled in the 3rd, 6th, and 12th month after the operation and they filled out the questionnaire in the 6th month after the operation in the TIP. The mean follow up was 13 months. Three (11.1%) patients had meatus stenosis and two (7.4%) urethral fistula as a complication. Twenty-four (88.8%) patients reported that they were satisfied about penile length, 26 (96.2%) about the appearance of the meatus, 25 (92.5%) about the appearance of the glans penis, 22 (81.4%) about the appearance of the foreskin, 23 (85.1%) about the straightness of the penis with erection, and 24 (88.8%) about the overall appearance of the penis. All patients were satisfied about the urinary flow and seven (100%) patients who were sexually active reported that they were satisfied with vaginal penetration and sexual satisfaction. Conclusion Tubularized incised plate repair technique reveals good functional and cosmetic results even in adults who were circumcised.