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    Clinical manifestations of tuberous sclerosis complex
    (Yuzuncu Yil Universitesi Tip Fakultesi, 2013) Atay A.E.; Akbas H.; Sakar N.; Pasa S.; Ari S.; Ekin N.
    Tuberous sclerosis complex (TSC) is an autosomal dominant syndrome or in sporadic form characterized by hamartamatous lesions in multiple organs. It affects several sites such as skin, kidney, lung, heart, central nervous system and liver in diferent stages of disease. TSC is caused by mutations on either chromosome 9 (9q34, the TSC1 gene) or chromosome 16 (16p13, TSC2 gene). TSC1 and TSC2 genes encode proteins called tuberin and hamartin; respectively. Although the pathogenetic mechanism is exactly unknown, a possible mechanism is a GTPase-activating protein against Rheb (Ras homolog enriched in brain), which regulates mTOR (mammalian target of rapamycin) signaling. The mammalian target of rapamycin (mTOR), is a serine-threonine kinase that increases cell proliferation and growth. We aimed to review the clinical manifestations and their predictive role on the course of disease.
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    Clinical significance of elevated antinuclear antibody test in patients with Hodgkin's and Non-Hodgkin's lymphoma: A single center experience
    (2008) Altintas A.; Cil T.; Pasa S.; Danis R.; Kilinc I.; Ayyildiz O.; Muftuoglu E.
    Aim. There is an increased risk of lymphoma subsequent to autoimmune conditions. Autoimmune disorders may occur in the course of lymphomas. In this study, the association of autoimmunity and related autoantibodies within non-Hodgkin's (NHL) and Hodgkin's lymphoma (HL) patients has been investigated. Methods. The study enrolled 119 patients affected by NHL and 60 patients affected by HL for the presence of autoantibodies and autoimmune diseases. Afterwards, the results between the two lymphoma groups have been confronted. Results. Autoimmune diseases were diagnosed in eight (6.7%) patients with NHL and three patients with HL (5%) (P=0.651). Thirty-four (28.5%) patients with NHL and 14 (23.3%) patients with HL displayed autoantibody positivity (P=0.083). As regards HL cases, antinuclear antibodies (ANA) were detected in 12 (20%) and anti PM-Scl in two patients (3.3%). None the patients had anti Jo-1, anti Scl-70, anti Sm, anti nRNP/Sm, anti single-stranded DNA (anti-ssDNA), anti double-stranded DNA (anti-dsDNA), antihistones, antinucleosomes, anti SS-A, anti SS-B or anti CENP-B autoantibodies. In patients affected by NHL ANA was detected in 16 (13.4%), anti SS-A and anti SS-B in two (1.7%), anti CENP-B in eight (6.7%) and anti PM-Scl in eight patients (6.7%). None of the patients had anti Jo-1, anti Scl-70, anti Sm, anti nRNP/Sm, anti ssDNA, antihistones or antinucleosome antibodies. There was a statistically significant difference between patients with HL and NHL in terms of anti CENP-B positivity (P=0.040). Conclusion. In conclusion, ANA and related autoantibodies can frequently be detected during lymphoma treatment. However, the majority of lymphoma patients with positive ANA did not display autoimmune diseases, demonstrating the lack of a strict correlation between the presence of ANA and autoimmune diseases.
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    Sorption characteristics of transition metalions (Co, Ni) on sodium humate sorbents
    (International Journal of Chemical Sciences, 2014) Taubayeva A.S.; Dzhusipbekov U.Z.; Nurgalieva G.O.; Temel H.; Pasa S.
    The main objective of this work was to study the possibility of using sodium humate as a sorbent for water purification of water from heavy metal ions (Co & Ni). Studied was complexing and sorption properties of sodium humate. Metal-humate complexes were also obtained by ion-exchange procedure with sodium humate by employing the metal salts such Co(CH3COO)2·4H2O, NiSO4·6H2O. Maximum sorption percentages of humate achieved for 5 ppm 91.5%, 50 ppm 90.4%, 500 ppm 68.6% for Co(II) and 90% of 5 ppm, for 50 ppm 93.25%, 500 ppm 87.43% for Ni (II). Humate and metal ion interaction was investigated with special emphasis on the effects of pH, metal ions concentration and humate concentration. It has been found that the interaction of humate with metal ions in solution decreases with increases metal ion concentration and also increases with increases humate concentration. The pH experiment was investigated in the range for cobalt sorption was performed at a constant pH of 4, pH of the nickel ratio of 5, metal concentration was selected (5 mg/L, 50 mg/L, 500 mg/L), the sorbent was determined with the amount of 0.05 g, 0.1 g, 0.25 g, 0.5 g, 1 g, and 2 g. It is stated that sorption degree increases from 15 minutes to 2 hrs. The adsorption of toxic metal ions with sodium humate was measured by atomic absorption spectroscopy (AAS). All the obtained complex compounds were analyzed and characterized by FT infrared spectroscopy (FTIR), scanning electron microscopy (SEM).
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    Sorption removal of Pb2+, Cd2+, Cu2+ from diluted acid solution by chitosan modified zeolite
    (University of Chemical Technology and Metallurgy, 2018) Kussainova M.Z.; Chernyakova R.M.; Jussipbekov U.Z.; Temel H.; Pasa S.; Kaiybayeva R.A.; Agatayeva A.A.
    The results of investigations on sorption activity of chitosan modified natural zeolite in regard to the simultaneous presence of Pb2+, Cd2+ and Cu2+ are presented. The influence of the process duration and the cations concentration on the degree of their adsorption in diluted (20 % H3PO4) phosphoric acid is determined. The sorption curves show peaks at the 5-th and the 10-th minute most probably because of desorption from the sorbent. Under identical concentrations of all heavy metal cations studied (CPb 2+ = CCd 2+ = CCu 2+), the sorption degree in respect to lead cations is within the range of 78.02 % - 90.65 %, that in respect to cadmium cations varies from 71.22 % to 92.39 %, while that in respect to copper - from 42.00 % to 95.26 %. The character of the sorption curves recorded at identical concentrations of Pb2+ and Cd2+ but at a greater content of Cu2+ is the same. The degree of cadmium cations sorption varies from 92.39 % to 70.22 %. Cu and Pb cations are sorbed in a less amount. The degree of their sorption within 10 min refers to 88.42 % and 90.65 %, respectively, in case Cpb2+ = CCd2+ < CCu 2+.