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Öğe Antibacterial effect of Some New Metal Complexes with Schiff Base Ligands on Gram-positive Bacteria (Staphylococcus aureus) and Gram-negative Bacteria (Pseudomonas aeruginosa)(Dicle Üniversitesi Fen Bilimleri Estitüsü, 2012) Akbolat, Nezahat; Yıldız, Abdulnasır; Temel, Hamdi; Paşa, Salih; Yeşil, Ö. Faruk; Gül, Kadri[Özet Yok]Öğe Antibacterial effect of some new metal complexes with schiff base ligans on gram-pozitive bacteria (Staphlococcus aureus) and gram-negative bacteria (Pseudomonas aeruginosa)(Dicle Üniversitesi, 2012) Akbolat, Nezahat; Yıldız, Abdulnasır; Temel, Hamdi; Paşa, Salih; Yeşil, Ömer Faruk; Gül, Kadri[Abstract Not Available]Öğe Biological activities of some transition metal complexes derived from N,N -bis salicylidene -1,2-bis- o - and p - aminophenoxy ethan(Dicle Üniversitesi, 2013) Temel, Hamdi; Uçmak, Hasan; Paşa, Salih; Yılmaz, Mustafa A.; Hoşoğlu, SalihThe Schiff base ligands N,N -bis salicylidene -1,2-bis- o-aminophenoxy ethane L1 and N,N -bis salicylidene 1,2-bis- p-aminophenoxy ethane L2 were synthesized for this study. The Cu II , Ni II , Zn II complexesof L1 and the Cu II , Co II , Zn II complexes of L2 were obtained with various transition metal salts.These compounds were evaluated against to the common infectious bacteria in human such as E. coli,Pseudomonas, Acinetobacter and Staphylococcus strains. The copper complexes of both L1 and L2 were foundeffective against Staphylococcus strains. Staphylococcus strains are common pathogens in hospital environment.Thus, their copper complexes L1-Cu and L2-Cu may be useful in hospital hygieneÖğe Bor türevi kimyasallarla çeşitli bileşiklerin sentezi ve uygulamaları(2015) Paşa, SalihBor minerali ve onun türevleri olan bileşikler; tarımdan sanayiye, tıptan ilaç ve kozmetik sanayisine, enerjiden iletişim araçlarına kadar çeşitli endüstri dallarında farklı malzeme ve ürünlerin üretiminde kullanılmaktadır. Böyle birçok alanda kullanılabilir olmasından dolayı günümüzde büyük önem taşımaktadır. Özellikle kanser üzerine yapılan araştırmalardan bor nötron yakalama tedavisi (BNCT), bor ve bor türevi bileşiklerin önemli bir yönünü ortaya koymaktadır. Kısacası bor çalışmaları insanlığın ihtiyaçları için geleceğe ışık tutabilecektir. Bu tez çalışmasında N, O donör atomlarını içeren 2,2'-(1E,1'E)-(etan-1,2-diilbis(azan-1- il-1-yiliden))bis(methan-1-il-1-yiliden)diphenol ve 2,2'-(propan-1,3-diilbis(azan-1-il-1-yiliden)) bis(methan-1-il-1-yiliden)diphenol ligandlarıyla boronik türevi maddeler etkileştirilerek yeni türden bor kompleksleri elde edilmiştir. Sentez basamağında elde edilen tüm bileşikler 1H & 13C NMR, LC-MS-IT-TOF, LC-MS/MS, TGA/DTA, UV-Vis., Elementel Analiz, XRD, SEM, FTIR gibi spektroskopik cihazlar kullanılarak karakterize edilmiştir. Deneysel basamakta öncelikli olarak ligandların sentezleri gerçekleştirildi. Bu ligandlar ile fenil boronik asitin farklı fonksiyonel gruba sahip formları ile reflaks sistemi kullanılarak borlu bileşikleri elde edildi. Bu kompleksler transfer hidrojenasyonda kullanılarak moleküllerin katalitik etkinliği araştırıldı. Ayrıca NaBH4’ün dietilen glikol dimetil eter ve 3,5-lutidin ile tek kristal çalışmaları yapıldı. Bu kristallerden NaBH4:diglim kristalleri asetofenonun kiral indirgenmesinde kullanıldı. NaBH4:3,5-lutidin kristallerinin ise X-ışınları ile yapısı aydınlatılarak bor içerikli piridin türevi ile oluşturduğu yeni bileşik araştırmaya eklendi. Aldehit grubu içeren boronik asit türevleri ile amin grubu içeren aromatik bileşikler etkileştirilerek yeni türden bor içeren imin(C=N) ligandları elde edildi. Bu boronik Schiff bazı ligandları antikanser ve antimikrobiyal amaçlı kullanıldı. Prostat kanser hücreleri üzerine yapılan çalışmalarda sağlıklı hücrelerin canlı kalarak, kanserli hücrelerin canlılığının düştüğü görüldü. Ayrıca 2,2-difenil-1-pikril hidrazil (DPPH) standardına karşı antioksidan özelliği çalışıldı. Fiziksel uygulamada ise boyaya duyarlı güneş hücreleri (DSSC) elde edilmesinde kullanıldı. Güneş hücresi olarak kullanılabilme verimleri ölçüldü. Yapılan tüm uygulamalar, bor türevi olan bu bileşiklerin ilgi çekici bir şekilde birçok disiplinde önemli bir yere sahip olduğunu göstermiştir.Öğe Boronic modified quercetin molecules: Synthesis and biological investigations with molecular docking verification(Elsevier B.V., 2023) Temel, Hamdi; Paşa, Salih; Atlan, Metin; Türkmenoğlu, Burçin; Ertaş, AbdulselamQuercetin is an essential compound belonging to the flavanol group, which is a derivative of bioflavonoids found in fruits and vegetables. Quercetin has various pharmacological properties such as anticancer, antioxidant, anti-inflammatory, antiviral, antihistamine, and antitumor. Based on these important properties, the quercetin compound was modified with various boronic acids and new types of quercetin-based boronic (QB) compounds were synthesized. In the current study, we have synthesized quercetin-based boronic compounds to obtain more effective molecules by doping the biological activity properties of quercetin naturally in its structure. In this purpose, 6‑methoxy naphthalene boronic acid, 1,4-phenyl diboronic acid, 4‑methoxy phenylboronic acid, 6‑methoxy-3-pyridinylboronic acid, 3-formyl-4-methoxyphenyl boronic acid compounds were used. The synthesized compounds were structurally enlightened by mass, 13C NMR, 1H NMR, and FTIR spectroscopy. Then, the antioxidant, anticholinesterase, antiurease, antityrosinase and toxic-cytotoxic effects of these molecules were tested. QB compounds synthesized and examined in vitro in the study were also analyzed by molecular docking. Molecular docking, one of the structure-based drug design methods, has been applied to support experimental data. It was determined that QB compounds showed more significant efficacy than the reference substance employed in antioxidant and enzyme activity studies. As a result of molecular docking analysis, the binding energy parameter values and active binding site amino acid residues of the compounds were determined. Obtained novel boronic compounds might be associated as drug candidate due to consistent results both in experimental and molecular docking results.Öğe Cross-coupling reactions in water using ionic liquid-based palladium(II)-phosphinite complexes as outstanding catalysts(Wiley, 2014) Meriç, Nermin; Aydemir, Murat; Işık, Uğur; Ocak, Yusuf Selim; Rafikova, Khadichakhan; Paşa, Salih; Kayan, Cezmi; Durap, Feyyaz; Temel, Hamdi; Zazybin, Alexey G.; 0000-0003-0899-1948; 0000-0002-6244-9327; 0000-0002-4792-8821Two new phosphinite ligands based on ionic liquids [(Ph2PO)C7H14N2Cl]Cl (1) and [(Cy2PO)C7H14N2Cl]Cl (2) were synthesized by reaction of 1-(3-chloro-2-hydoxypropyl)-3-methylimidazolium chloride, [C7H15N2OCl]Cl, with one equivalent of chlorodiphenylphosphine or chlorodicyclohexylphosphine, respectively, in anhydrous CH2Cl2 and under argon atmosphere. The reactions of 1 and 2 with MCl2(cod) (M=Pd, Pt; cod=1,5-cyclooctadiene) yield complexes cis-[M([(Ph2PO)C7H14N2Cl]Cl)(2)Cl-2] and cis-[M(Cy2PO)C7H14N2Cl]Cl)(2)Cl-2], respectively. All complexes were isolated as analytically pure substances and characterized using multi-nuclear NMR and infrared spectroscopies and elemental analysis. The catalytic activity of palladium complexes based on ionic liquid phosphinite ligands 1 and 2 was investigated in Suzuki cross-coupling. They show outstanding catalytic activity in coupling of a series of aryl bromides or aryl iodides with phenylboronic acid under the optimized reaction conditions in water. The complexes provide turnover frequencies of 57 600 and 232 800h(-1) in Suzuki coupling reactions of phenylboronic acid with p-bromoacetophenone or p-iodoacetophenone, respectively, which are the highest values ever reported among similar complexes for Suzuki coupling reactions in water as sole solvent in homogeneous catalysis. Furthermore, the palladium complexes were also found to be highly active catalysts in the Heck reaction affording trans-stilbenes. Copyright (c) 2014 John Wiley & Sons, Ltd.Öğe Electrical and photoelectrical behaviour of heterojunctions based on novel oligomeric metal complexes(Wiley, 2015) Atlan, Metin; Ocak, Yusuf Selim; Paşa, Salih; Temel, Hamdi; Tombak, Ahmet; Kılıçoglu, Tahsin; Akkılıç, Kemal; Aydemir, Murat; 0000-0002-4238-5012; 0000-0002-4792-8821; 0000-0002-9997-1653; 0000-0002-7150-6522Naringenin-based Schiff base ligands with 4-aminobenzoic hydrazide were obtained as a unilateral form (L-1). The ligand was oligomerized by oxidative polycondensation reaction with NaOCl as an oxidant in an aqueous alkaline medium at 90 degrees C to form a functional oligomer (L-2), and its transition metal complexes such as those with Cu(II), Ni(II) and Zn(II) were prepared. The monomer and the oligomeric compounds were characterized using various techniques. Optical and electrical properties of the complexes were also investigated. All compounds showed indirect band gaps and they can be accepted as being in the semiconductor class. Organic-inorganic hybrid devices were obtained using n-Si inorganic semiconductor and the complexes. The characteristic parameters of the devices were determined using current-voltage (I-V) and capacitance-voltage measurements in the dark. Photoelectrical properties of the devices were investigated using I-V measurements under a solar simulator with an AM1.5 global filter. Copyright (C) 2015 John Wiley & Sons, Ltd.Öğe Histopathological, antioxidant, and enzyme activity of boronic incorporated catechin compound: Screening of bioactivity with molecular docking studies(Pleiades Publishing, 2024) Paşa, Salih; Atlan, Metin; Temel, Hamdi; Türkmenoğlu, Burçin; Ertaş, Abdulselam; Okan, Aslı; Yılmaz, Seher; Ateş, ŞükrüAbstract: Objective: Boron structures play a crucial role in biological treatments due to their unique chemical properties. They are used in pharmaceuticals for their potential as enzyme inhibitors and as anti-inflammatory agents. Boron-containing compounds are also explored in drug delivery systems, leveraging their ability to cross cell membranes effectively. Additionally, boron-based materials are studied for their applications in biomaterials, such as wound healing and tissue engineering, highlighting their diverse applications in biological treatments. Methods: The study aims to elucidate the biological properties of catechin, a natural phenolic compound, by modifying it with phenylboronic acid. The Catechin-based boronic compound (CBC) was synthesized. The antioxidant and enzyme activity were studied. Histopathological experiments to vital organs and molecular docking studies were also conducted. Results and Discussion: The (CBC) showed meaningful antioxidant and enzyme activity when compared to standards. The effect of the (CBC) on tissues was demonstrated by in vivo experiments. Histopathological evaluation of vital organs in male Sprague Dawley rats was demonstrated by Hematoxylin–Eosin staining. The study has supported the antioxidant property of (CBC), also has a natural origin based on its structure. Besides, the antiurease and antityrosinase activities of catechin were tested for the first time. Furthermore, in silico approaches also supported the acceptable biological activity results that were experimentally examined. The interactions of AChE, BChE, urease, and tyrosinase enzymes with the (CBC) were investigated theoretically via molecular docking, and the binding parameter values were also shared. The (CBC) demonstrated radical scavenging activity. The in vivo experiments on rats were carried out and the (CBC) showed no negative effects on the vital organs. It was seen that the experimental results were in good agreement with the theoretical calculations. Conclusions: The analysis of the crystal structures of AChE, BChE, urease, and tyrosinase enzymes in relation to the compound (CBC) yielded striking results, highlighting the compound’s promising potential as a therapeutic agent.Öğe Removal of Pb2+, Cd2+, and Cu2+ from phosphoric acid solution using the chitosan-modified natural zeolite(Wiley-Blackwell, 2015) Kussainova, M. Z.; Chernyakova, R. M.; Dzhusipbekov, U. Z.; Paşa, Salih; Temel, Hamdi; 0000-0003-1243-3527; 0000-0002-4792-8821Sorption ability of the chitosan-modified natural zeolite for Pb2+, Cd2+, and Cu2+ cations was investigated. The influence of time and concentration of heavy metals on their sorption from concentrated (85% H3PO4) phosphoric acid was determined. At 20 and 40 min of sorption curves, there are a number of maxima probably due to desorption of cations from the sorbent into the acid. According to the results, sorption of the modified zeolite for lead cation is the least in the whole interval of time. In the case of equal concentrations of all cations (C-Pb = C-Cd = C-Cu), sorption of lead, cadmium, and copper was 94.81-95.09%, 96.55-97.50%, and 97.53-98.14%, respectively. Sorption curves in the case of equal Pb2+ and Cd2+, but higher concentrations of Cu2+, are the same for all cations. Sorption of cadmium varies from 95.48% to 97.55%. Copper and lead sorbed in a less amount, in the case of (C-Pb = C-Cd = C-Cu), their sorption in 10 min was 95.42% and 97.55%, respectively. As in the case of equal concentrations of all cations (C-Pb = C-Cd = C-Cu), the sorptions of copper, cadmium, and lead were (92.09-96.93%), (92.13-95.37%), and (91.35-94.45%), respectively, in the case of (C-Cb = C-Cu < C-Cd). Physico-chemical methods of analysis are as follows: Fourier transform infrared spectroscopy, scanning electron microscopy, X-ray powder diffraction patterns, and Brunauer-Emmett-Teller have shown that natural zeolite is activated without destroying the structure and adsorbs lead, as well as cadmium and copper cations. (C) 2015 Curtin University of Technology and John Wiley & Sons, Ltd.Öğe Silane doped biodegradable starch-PLA bilayer films for food packaging applications: Mechanical, thermal, barrier and biodegradability properties(Elsevier, 2021) Gürler, Nedim; Paşa, Salih; Temel, HamdiIn this work, pure potato starch (PPS) purified from waste potato starch, was recovered and used. PPS was modified by 3-APTMS (3-(aminopropyl) trimethoxy silane) to manufacture a crosslinked film. To obtain a bilayer PPS-3APTMS-PLA film, the polylactic acid (PLA) was employed with PPS-3APTMS by casting method. The resulting materials, PPS-3APTMS and PPS-3APTMS-PLA were characterized by attenuated total reflectance fourier transform infrared (ATR-FTIR), x-ray Diffraction (XRD), scanning electron microscopy (SEM), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA). The silane-doped bilayer films have more thermal stability compared to PPS. The mechanical, solubility, swelling, water vapor permeability, optical properties and biodegradability under controlled compost conditions were examined. When the tensile strength of the PPS, PPS-3APTMS and PPS-3APTMS-PLA films were evaluated, the tensile strength (TS) were to 1.017 +/- 0.35 MPa, 1.437 +/- 0.19 MPa and 10.918 +/- 1.30 MPa, respectively. The PPS and PPS-3APTMS films were not elongation at break, while it was found about 21.94 +/- 9.48 for the bilayer PPS-3APTMS-PLA film. The solubility, swelling, water vapor permeability, and transparency decreased for bilayer films. The water vapor permeability of PPS, PPS-3APTMS and PPS-3APTMS-PLA films were obtained as 31.69 +/- 0.4 x 10-7 g s-1 m-1 Pa-1, 28.96 +/- 0.4 x 10-7 g s-1 m-1Pa-1,and 14.26 +/- 0.3 x 10-7 g s-1 m-1Pa-1, respectively. Then, the biodegradability of films was performed under controlled compost conditions for 46 days according to ISO-14,855 standard. The biodegradation of PPS, PPS-3APTMS and PPS-3APTMS-PLA was also calculated as 9.30%, 5.45% and 5.08%. Biodegradation of PPS-3APTMS film decreases compared to PPS. Furthermore, the biodegradation value of bilayer film, PPS-3APTMS-PLA, was also decreased due to the slower degradation tendency of PLA. The contribution to the reusability of waste starch and the modifying of starch for food packaging and coating applications are the novelty aspects of the current study. (c) 2021 Published by Elsevier B.V. on behalf of Taiwan Institute of Chemical Engineers.Öğe Tiyo Schiff bazları ve komplekslerinin sentezi, karakterizasyonu, katalitik etkilerinin incelenmesi ve diyot uygulamaları(2015) Paşa, SalihBu çalışmada, tiyo Schiff bazları, N,N ? -bis(2-hidroksi-1-naftaldehit)-1,4-bis(2-amino tiyofenol)etan (L1) ve N,N'-bis(2-hidroksi-1-naftaldehit)-1,4-bis(2- amino tiyofenol)bütan'ın sentezi (L2) gerçekleştirilmiştir. Sentezlenen bu Schiff bazı ligandlarının Cu(II), Co(II), Ni(II) ve Pd(II) kompleksleri sentezlenmiştir. Ligandların ve komplekslerin yapıları 1H NMR, IR, Uv-vis., Elemental Analiz, Magnetik Süssebtibilite, Kondüktometrik Ölçümler ve Kütle Spektrumu ile aydınlatılmıştır. İlk olarak, L1 ve L2 ligandlarının Suzuki eşleşme tepkimelerindeki katalitik etkinlikleri özellikleri incelenmiştir. Bunun için ligandlar; Pd(AcO)2, aril bromür ve boronik asit ile argon atmosferi altında ısıtıldı. Reaksiyon sonunda etil asetat ile ekstrakte edildi ve verim hesabı yapıldı. Daha sonra L1, L2 ve L1-Cu 'ın elektrokimyasal davranışları siklik voltametri tekniğiyle araştırılmıştır. Dimetilsülfoksit (DMSO) içinde, destek elektrolit n-tetrabütil amonyum perklorat (TBAP) varlığında ölçümler alınmıştır. Platin disk elektrot, çalışma elektrodu olarak kullanılırken, yardımcı elektrot olarak platin tel, referans elektrot olarak da Ag/AgCI (3,5 M KCl) elektrot kullanılmıştır. Ölçümler öncesinde ligand ve metal komplekslerini içeren çözeltiler yüksek saflıktaki azot gazı ile oksijenden tamamen arındırılmıştır. Bu sayede çözeltinin havadan etkilenmesi önlenmiştir. Elde edilen ölçümler grafiklerle gösterilmiştir. Son olarak sentezlenen ligandlar ve bunların Co(II), Ni(II) ve Pd(II) komplekslerinden saçtırma yöntemi(Sputtering), daldırma (deep coating), arka kontak oluşturma(Omik kontak) gibi yöntemlerle diyotlar oluşturulup bunların elektriksel parametreleri ölçülmüştür. Anahtar Kelimeler: Tiyo Schiff Bazı ve Kompleksleri, Suzuki Eşleşme Reaksiyonları, Siklik Voltametri, Schottky Diyotları, Omik kontak.
