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    Antioxidant and Anticholinesterase Activities of Some Dialkylamino Substituted 3-Hydroxyflavone Derivatives
    (Bentham Science Publ Ltd, 2017) Culhaoglu, Burcu; Capan, Asli; Boga, Mehmet; Ozturk, Mehmet; Ozturk, Turan; Topcu, Gulacti
    Background: Flavones, are a class of naturally occuring polyphenolic compounds which have 2-phenylchromen-4-one structure. Various studies showed that flavones have several pharmacological activities such as antioxidant, anti-inflammatory, antimicrobial, cytotoxic, antitumour and antiallergic. In the present study, 3-hydroxyflavones also called flavonols, posessing 4'-dialkylamino moiety were synthesized, and their antioxidant and anticholinesterase activities were investigated by comparison with unmodified 3-hydroxflavone. Method: For investigation of antioxidant potential, radical scavenging assays (DPPH., ABTS(+)-, O-2(-)) were used along with CUPRAC and lipid peroxidation inhibitory assays, as well as anticholinesterase activity by Ellman method. Results: The best results were obtained for 4'-N, N-dimethyl flavonol (1) in both antioxidant and anticholinesterase activity tests, possibly due to its least steric hinderance effect. It exhibited remarkable DPPH free radical scavenging activity (2.43 perpendicular to 0,09 mu g/mL) competing with a standard compound quercetin (2.10 +/- 0,10 mu g/mL). Moreover, the other tested flavonols also showed high antioxidant activities. Compounds 5 and 6 exhibited close IC50 values to those of compound 1. Conclusion: Antioxidant activity test results were found to be well correlated with anticholinesterase activity test results indicating possible role of antioxidant compounds in the treatment of Alzheimer's disease.
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    Electrochromic properties of poly(diphenyldithieno[3,2-b;: 2?,3?-d]thiophene)
    (Elsevier Science Sa, 2006) Mert, Olcay; Sahin, Elif; Ertas, Erdal; Ozturk, Turan; Aydin, Engin A.; Toppare, Levent
    A conducting polymer of diphenyldithieno[3,2-b;2',3'-d]thiophene (DPhDTT) was synthesized via potentiodynamic method in dichloromethane (DCM)/acetonitrile (AN) (1:9(v/v))-NaClO4/LiClO4 (0.1:0.1 M) solvent-electrolyte couple. Characterizations of the resulting homopolymer were performed by cyclic voltarnmetry (CV), Fourier transform infrared (FTIR) and UV-Vis spectroscopy. Moreover, the spectroelectrochemical and electrochromic properties of the homopolymer films were investigated. Consequently, P(DPhDTT)/PEDOT device was constructed and their characteristics were examined in detail. A potential range of 0.0-2.0 V was found to be suitable for operating the P(DPhDTT)/PEDOT device between yellow and blue colors. The device reveals good open circuit memory and stability. (c) 2006 Elsevier B.V. All rights reserved.