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Öğe Anticardiolipin antibodies in hemodialysis patients with hepatitis C and their role in fistula failure(Dustri-Verlag Dr Karl Feistle, 2009) Ozmen, S.; Danis, R.; Akin, D.; Batun, S.Background/Aims: Several conflicting results are presently reported regarding raised IgG and IgM-anticardiolipin antibodies (ACA) titers in hemodialysis (HD) patients and their role in vascular access dys-function. We aimed to determine the prevalence of both IgM and IgG-ACA titers and to analyze retrospectively their role in primary and secondary arteriovenous fistula (AVF) failure in a homogeneous group of HD patients with chronic hepatitis C. Methods: This study included 103 adults on maintenance hemodialysis with chronic hepatitis C infection. All participants had blood samples drawn predialysis and after an overnight fast. Analysis included biochemistry, IgG and IgM ACA, Anti-HCV, HBsAg, serum HCV RNA and HCV genotyping. Results: The prevalence of IgG-ACA was 14.6% (15/103). No patient had a positive value of the IgM-ACA test. HCV replication was detected in 52 of 76 patients. The most common HCV genotype was genotype 1 (90%). The percentage of females was higher in ACA(+) group (p = 0.038). There were no significant differences between subjects with and without ACA-IgG regarding other parameters studied. No difference in regard to AVF survival was detected between ACA(+) and ACA(-) groups (p > 0.05). Conclusion: We found no significant differences in primary or secondary AVF failure between patients with elevated and normal ACA. Therefore, we conclude that AVFF may be caused by factors other than ACA in these patients. More prospective studies are needed to confirm this observation.Öğe Does the direction of arterial needle in AV fistula cannulation affect dialysis adequacy?(Dustri-Verlag Dr Karl Feistle, 2008) Ozmen, S.; Kadiroglu, A. K.; Ozmen, C. A.; Danis, R.; Sit, D.; Akin, D.; Yilmaz, M. E.Aim: The direction of arterial access needles in fistulas and grafts has been a subject of some controversy and there is no study comparing the results either direction of arterial needle placement in cannulation of arteriovenous fistula. We compared mean urea reduction rate (URR) and Kt/V in the same HD patients when dialyzed via antegrade or retrograde arterial needle cannulation. Materials and methods: This was a study involving 22 adults oil maintenance hemodialysis for more than 6 months. Doppler US examinations of arteriovenous fistula were performed in all Subjects. Pre-dialysis and post-dialysis blood samples were obtained at the patient's midweek HD treatment 4 times a month for each direction. Arterial needle was placed in retrograde direction for the first month. Oil the second month, the direction of arterial needle was converted to antegrade. Means were compared by paired t-test. Results: Mean URR and eKt/Vof retrograde cannulation were 74.2 +/- 7.2% and 1.57 +/- 0.33. The results were indifferent statistically from those of antegrade cannulation (73.0 +/- 8.7% and 1.57 +/- 0.35 (p = 0.123)). Mean fistula blood flow was 931 +/- 483 ml/min. No cannulation complication was observed during the study period for both directions. Conclusions: Both antegrade and retrograde arterial needle placement may be preferred according to center experience without concern of HD adequacy. Longterm outcomes of antegrade and retrograde arterial needle placement such as AVF failure, thrombosis, and stenosis warrant further studies.Öğe Parathyroid hormone as a marker for the differential diagnosis of acute and chronic renal failure(Taylor & Francis Ltd, 2007) Ozmen, S.; Danis, R.; Akin, D.; Cil, T.; Yazanel, O.It is often difficult to distinguish acute renal failure clinically from chronic renal failure, especially in patients who do not have records of their medical history. We investigated the magnitude of iPTH increase in ARF and the potential role of i1PTH as a marker for differential diagnosis of ARF and CRF in new patients referred to our renal unit. We prospectively analyzed 122 (ARF n = 64, CRF n = 58) patients referred to our renal unit with serum creatinine higher than 2 mg/dL. ROC curve analysis was performed to investigate role of iPTH for differentiating ARF from CRF. The sensitivity, specificity, and positive predictive value of iPTH in discrimination of ARF and CRF were calculated. There was no statistically significant difference regarding the means of age, sex distribution, and serum chemistry between patients with ARF or CRF. But serum iPTH (D < 0.0001) levels were lower in patients with ARF than in those with CRF. A cutoff, set at 170pg/mL for iPTH to discriminate patients with CRF, yielded a sensitivity of 88% and a specificity of 89%. This study confirms that the iPTH measurement is of clinical value in differentiating acute from chronic renal failure.Öğe The reliability and validity of the Turkish version of a childhood asthma control test(Wiley-Blackwell, 2011) Soyer, Uysal O.; Keskin, O.; Uzuner, N.; Yazicioglu, M.; Kilic, M.; Artac, H.; Ozmen, S.[Abstract Not Available]Öğe The role of lean body mass for GFR estimation in patients with CKD whit various BMI(Springer, 2008) Ozmen, S.; Kaplan, M. A.; Kaya, H.; Akin, D.; Danis, R.; Bellur, B. Kizilkan; Yazanel, O.[Abstract Not Available]Öğe A simple way to estimate mean plasma glucose and to identify Type 2 diabetic subjects with poor glycaemic control when a standardized HbA1c assay is not available(Wiley, 2006) Ozmen, S.; Cil, T.; Atay, A. E.; Tuzcu, A. K.; Bahceci, M.Aims To evaluate the relationship between HbA(1c) and fasting plasma glucose (FPG) and postprandial plasma glucose (PPG) levels, and to estimate the mean plasma glucose (mPG) derived from FPG and PPG that would predict Type 2 diabetic subjects with poor glycaemic control. Methods FPG, PPG and HbA(1c) values from 565 Type 2 diabetic patients (247 men and 318 women) were recorded. Linear regression analysis and Pearson's correlation was used to determine the relationship between HbA(1c), FPG and PPG. FPG and PPG were included as explanatory variables of HbA(1c) in linear regression analysis. Results The American Diabetes Association's objective of achieving an HbA(1c) level < 7.0% was obtained in 26.2% of the patients. The coefficients of FPG and PPG which determined HbA(1c) were similar. Therefore, mPG was calculated using the equation (FPG + PPG)/2. Pearson's correlation coefficient for HbA(1c) and FPG, PPG and mPG were 0.723 (P < 0.0001), 0.734 and 0.761 (P < 0.0001), respectively. A mPG cut-off value of 10 mmol/l predicted an HbA(1c) > 7% in the whole population, with a sensitivity of 84.2% and specificity of 80.4%. The area was high (0.90) in receiver-operating characteristic (ROC) curve analysis performed to examine the performance of mPG to predict HbA(1c) > 7%. Conclusions The mPG derived from FPG and PPG correlates strongly with HbA(1c). We therefore suggest that using a cut-off of 10 mmol/l for mPG may be appropriate in diabetes management in the primary-care setting, where most management of Type 2 diabetes occurs.Öğe The Utility of Childhood Asthma Control Test and its Relationship with Control Measures and with the Decisions Made by Asthma Specialist(Mosby-Elsevier, 2010) Sekerel B, E.; Keskin, O.; Uzuner, N.; Yazicioglu, M.; Kilic, M.; Artac, H.; Ozmen, S.[Abstract Not Available]
