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Öğe CD147 expression in uterine smooth muscle tumors, and its potential role as a diagnostic and prognostic marker in patients with leiomyosarcoma(Old City Publishing, 2014) Ozler A.; Evsen M.S.; Turgut A.; Sak M.E.; Tunc S.Y.; Agacayak E.; Alabalik U.Objective: To investigate the role of CD147 expression in uterine smooth muscle neoplasms, as a potential diagnostic and prognostic marker in patients with leiomyosarcoma (LMS). Study Design: We investigated CD147 protein expression in uterine smooth muscle tumor samples from patients diagnosed with leiomyoma (n = 22), atypical leiomyoma (BLM) (n = 5), smooth muscle tumor of uncertain malignant potential (STUMP) (n = 14), and LMS (n = 22). The intensity and extensity of immunohistochemical staining were compared to determine its potential role in differential diagnosis. Spearman's rank correlation tests were performed to determine the relationship between CD147 expression and prognostic clinical and pathological criteria in the patients with LMS. Results: CD147 was strongly expressed in 81.8% (n = 18) of the LMS tissue samples. In fact expression of CD147 in LMS tissues was significantly higher than that of the three other uterine smooth muscle tumor types (p = 0.000). However, high CD147 expression was found in only one BLM sample and one STUMP sample. Furthermore, CD147 percent expression positively correlated with Ki67 percent expression (r = 0.466, p<0.05) and mitotic index (r = 0.554, p<0.05), respectively. Conclusion: Our results suggest that immunohistochemistry may be a helpful tool in determining whether CD147 is a useful marker in the differential diagnosis of certain uterine smooth muscle tumors. CD147 may also have prognostic value for patients with LMS. Yet, in order to determine the extent of this potential marker's utility as a diagnostic and prognostic indicator, a larger randomized multicenter study must be performed. © 2014 Old City Publishing, Inc.Öğe Human placental macrophages (Hofbauer cells) in severe preeclampsia complicated by HELLP syndrome(2013) Evsen M.S.; Kalkanli S.; Deveci E.; Sak M.E.; Ozler A.; Baran O.; Erdem E.OBJECTIVE: To evaluate Hofbauer cells in the placentas of women diagnosed with HELLP syndrome. STUDY DESIGN: The present study compared 20 patients with HELLP syndrome and 20 control patients with respect to demographics, hematological parameters and the presence of Hofbauer cells in placental samples. CD-68 antibody was used for immunohistochemical examination. The total number and size of Hofbauer cells were measured in the placental villi, and the proportion of Hofbauer cells relative to the vascular structure was also compared between groups. RESULT: The patient and control groups were similar according to baseline obstetric characteristics. White blood cell counts in patients with HELLP syndrome and the control group were 15,139 ± 4,169 and 10,806 ± 2,888, respectively, and were significantly increased among patients with HELLP syndrome (p<0.001). Hofbauer cell numbers in the placental villi of patients with HELLP syndrome were significantly elevated in comparison to normotensive controls (p=0.046). The proportion of Hofbauer cells in the placental villi according to proximity to the vascular structure were 3.85±1.66 in the HELLP group and 1.75±1.12 in controls (p<0.001). Sizes of the Hofbauer cells were not statistically different between groups. CONCLUSION: Increased Hofbauer cells may be associated with increased inflammation or may have an adaptive mechanism at the fetal site of the placenta in patients with HELLP syndrome. (Anal Quant Cytopathol Histopathol 2013;35:283-288). © Science Printers and Publishers, Inc.Öğe Hydronephrosis during pregnancy: How to make a decision about the time of intervention?(Medical Association of Zenica-Doboj Canton, 2014) Bodakci M.N.; Hatipoglu N.K.; Ozler A.; Turgut A.; Hamidi C.; Hatipoglu N.; Alan B.Aim To evaluate the role of doppler ultrasonographorin managing hydronephrosis during pregnancy. Methods The study included 27 pregnant patients with unilateral symptomatic persistent hydronephrosis (group 1) and 38 pregnant patients with physiological hydronephrosis of pregnancy (group 2). All pregnant patients underwent Doppler Ultrasonography to determine the Resistive Index (RI) and the difference between the RI of the corresponding and contralateral kidney (Delta Resistive Index = ?RI). Results There were no statistical differences between the two groups in terms of age, mean gestational period, or number of pregnancies. The mean renal RI of the hydronephrosis side was 0.68±0.05 in group 1 and 0.60±0.05 in group 2 (p<0.001). The mean ?RI of group 1 was significantly higher than the mean ?RI of group 2 (0.07±0.03 versus 0.02±0.01, respectively, p<0.001). The RI and ?RI were considered positive with values of ?0.70 and ?0.04, respectively, and the RI was sensitive in 44.4% and specific in 92.1% for intervention treatment. The corresponding values for ?RI were 88.9% and 89.5%. The positive predictive value and negative predictive value of ?RI for intervention were 85.7% and 91.9%, respectively. Conclusion It is much better to consider ?RI than RI when deciding on interventional treatment in hydronephrosis during pregnancy.Öğe Primary yolk sac tumor of endometrium: Report of two cases and review of literature(Old City Publishing, 2015) Ozler A.; Dogan S.; Mamedbeyli G.; Rahatli S.; Haberal A.N.; Dursun P.; Ayhan A.Primary YST of the endometrium is very rare, therefore there is no guideline for treatment. We report two cases of endometrial YSTs presenting different symptoms and showing different prognoses and discuss the clinical management of these tumors. The present report shows first time that bone and lung metastasis in primary YSTs of endometrium. As the number of reported cases with endometrial YSTs, more information about the prognosis of the disease may be obtained. © 2015 Old City Publishing, Inc.Öğe Serum levels of neopterin, tumor necrosis factor-alpha and Interleukin-6 in preeclampsia: relationship with disease severity.(2012) Ozler A.; Turgut A.; Sak M.E.; Evsen M.S.; Soydinc H.E.; Evliyaoglu O.; Gul T.There are many studies evaluating the role of inflammation in the pathogenesis of preeclampsia. However, little is known about the relationship between the severity of inflammation and the severity of preeclampsia due to insufficient of studies reporting this matter. To investigate the maternal serum concentrations of IL-6, TNF-alpha and Neopterin in patients with mild preeclampsia and severe preeclampsia and HELLP (hemolysis, elevated liver enzymes, low platelet count) syndrome in preeclampsia and determine their association with the severity of the disease. Patients, hospitalized with the diagnosis of preeclampsia between October 2011 and March 2012, were included in the study. The patients with preeclampsia were divided into three groups as mild preeclampsia, severe preeclampsia and HELLP syndrome. The control group was comprised of normotensive and uncomplicated pregnant women. The serum levels of IL-6, TNF-alpha and Neopterin (NEO) were determined, using enzyme-linked immunosorbent assay. Spearman's rank correlation tests were used for the correlations between the serum levels of inflammatory markers and the severity of preeclampsia. There was no observed significant difference among mean serum TNF-alpha and IL-6 levels of four groups (p > 0.05). The median serum concentration of NEO in subjects with mild preeclampsia of 14.1 nmol/L and severe preeclampsia of 14.8 nmol/L was significantly higher than that of 10.3 nmol/L in normotensive controls (p = 0.013; p = 0.000 respectively). In addition, the median serum concentration of NEO was detected to be highest in subjects with HELLP syndrome. The serum levels of NEO was well correlated with the severity of preeclampsia (r = 0.533, p = 0.000). The serum levels of NEO, an important marker of cellular immunity, associated with severity of disease in patients with preeclampsia.
