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Öğe An Analysis on Aerodynamic and Acoustic Changes After Thyroidectomy(Int College Of Surgeons, 2016) Yilmaz, Beyhan; Bakir, Salih; Yilmaz, Edip Erdal; Senhul, Engin; Uslukaya, Omer; Gul, Aylin; Ozkurt, Fazil EmreThe purpose of this study was to investigate the aerodynamic and acoustic changes after thyroidectomy without laryngeal nerve injury by using objective methods. Voice samples of sustained /alpha/ recorded from 44 adults preoperatively and nearly 1 week and 3 months after thyroidectomy were analyzed for mean vocal fundamental frequency (Mean Fo, Hz), maximum fundamental frequency (Max Fo, Hz), minimum fundamental frequency (Min Fo, Hz), jitter, shimmer, glottal to noise excitation ratio (GNE), irregularity, noise, overall severity, S time, Z time, S/Z ratio, and maximum phonation time (MPT). Voice samples were analyzed using the lingWAVES software. The comparisons of preoperative and early and late postoperative acoustic parameters revealed significant differences in Mean F0, Max F0, MPT, and S Time between the early and late postoperative periods. The voice changes after thyroidectomy were not affected by age, sex, or surgical procedure, but they differed between the benign and malignant nature of the tumor. Patients with malignant tumors showed a greater decrease in Mean F0 and Max F0 compared with the patients with benign tumors, and this difference was statistically significant. Voice changes may occur after thyroidectomy even in the patients with no evidence of laryngeal nerve damage, and these changes can be assessed with objective measurement methods. This information should be explained to the patients during the preoperative counseling, and proper informed consent is ethically and legally required for all planned thyroidectomies.Öğe Cultural adaptation of an olfactory test: the odour in bottle test (vol 52, pg 172, 2014)(Int Rhinologic Soc, 2014) Gul, Aylin; Akdag, Mehmet; Ozkurt, Fazil Emre; Yilmaz, Beyhan; Sengul, Engin; Bakir, Salih; Topcu, Ismail[Abstract Not Available]Öğe Does usage of a room air freshener affect the nasal mucosa?(Sage Publications Inc, 2014) Akdag, Mehmet; Bakir, Salih; Alabalik, Ulas; Ozkurt, Fazil Emre; Topcu, IsmailBackground: Effects of chemicals emitted from the room air freshener sprays (RAFSs) on nasal mucosa are still unclear. The purpose of this study was to investigate effects of RAFSs on the nasal mucosa of rats for different time intervals. Methods: Twenty-eight rats were randomly divided into four experimental groups: group 1 (n = 7) was the control group and not exposed to RAFS or other chemicals, group 2 (n = 7) was exposed to RAFS for 1 month, group 3 (n = 7) was exposed to RAFS for 2 months, and group 4 (n = 7) was exposed to RAFS for 3 months. Samples from the nasal septum were stained using hematoxylin and eosin solution, examined by a pathologist using a light microscope, and analyzed with Fisher's exact test. Results: We observed that distinct histopathological differences in the nasal mucosa of exposed rats depends on different time intervals (p < 0.05). Increased congestion was found after the 1st month of exposure (group 2). Although edema and mild inflammatory cell infiltration, including some eosinophils, was seen after the 2nd month (group 3), squamous metaplasia, numerous eosinophils, and intense inflammatory cell infiltration began after 3 months of exposure (group 4). Conclusion: Our results showed that continuous use of RAFS can cause inflammation and eosinophilic infiltration in rats, which begins after 2 months of exposure and may lead to metaplasia after 3 months. Because of differences in body size, geometry, and physiological responses of rats, the extrapolation of these results to humans is not straightforward. However, any such comparison should be made with caution. Finally, more performance is necessary to clarify this subject.Öğe THE EFFICACY OF DOPPLER ULTRASOUND ON CHRONIC SUPPURATIVE OTITIS MEDIA(Carbone Editore, 2015) Gul, Aylin; Akdag, Mehmet; Ozkurt, Fazil Emre; Aguloglu, Bulent; Ozkan, Hakan; Akturk, Adem; Yilmaz, BeyhanAims: The diagnostic techniques used in the diagnosis of lateral sinus thrombosis are invasive and pose a risk of stroke. For this reason, we aimed to evaluate the efficiency of Doppler ultrasonography, a simple, fast, and non-invasive technique in this field. Materials and methods: Patients presenting at our clinic with one-sided, chronic suppurative otitis media were included in the study. Internal jugular vein and internal carotid artery Doppler tests were conducted on the patients. The healthy ears of the patients were used as the control group. The values were compared statistically. Results: A total of 40 patients were included in the study 17 male (42.5%) and 23 female (57.5%). Seventeen patients had suppurative otitis media with cholesteatoma, and 23 patients had suppurative otitis media without cholesteatoma. According to Doppler ultrasonography parameters, no statistically significant differences were observed. However, when the chronic suppurative otitis media patients were compared to those without cholesteatoma, the internal jugular vein diameter was found to be reduced significantly in the group with cholesteatoma (p=0.047). Conclusion: The results of our study suggest that Doppler ultrasonography can be considered as a useful, fast, easy, and non-invasive method in the prognosis of cases with suspected lateral sinus thrombosis.Öğe Efficacy of N-Acetylcysteine on Wound Healing of Nasal Mucosa(Lippincott Williams & Wilkins, 2015) Yilmaz, Beyhan; Turkcu, Gul; Sengul, Engin; Gul, Aylin; Ozkurt, Fazil Emre; Akdag, MehmetPostoperative nasal mucosa healing is a highly complex and organized process, and the success rates of endoscopic sinus surgery and septoplasty surgeries are closely associated with the postoperative wound healing processes. In this experimental study, the authors' aim was to use histopathologic examination to investigate the effects of N-Acetylcysteine (NAC) on the wound healing of rat nasal mucosa after mechanical trauma. Twenty-one Sprague-Dawley rats were randomly divided into 3 groups: the nontreated group (N = 7), the control saline group (N = 7), and the NAC group (N = 7). No treatment was given to the nontreated group for 15 days. The control saline group received intraperitoneal injection of saline (2.5 mL/kg, intraperitoneal) for 15 days and the NAC group was intraperitoneally injected with NAC at a dose of 300 mg/kg/day for 15 days. At the beginning of the study, unilateral mechanical nasal trauma was induced with an interdental brush inserted through the right nostril in all rats. Samples were stained using hematoxylin and eosin solution, and were examined by a pathologist using a light microscope. The severity of inflammation was milder in the NAC group compared with that in the nontreated and saline groups (P < 0.05). The subepithelial thickness index was lower in the experimental group (P < 0.05). Goblet cell loss was reduced in the experimental group compared with the nontreated and saline groups (P < 0.05). NAC decreases inflammation and goblet cell loss. Therefore, NAC has potential beneficial effects on the wound healing of nasal mucosa in rats.Öğe Evaluation of Hearing and Outer Hair Cell Function of Cochlea in Patients With Psoriatic Arthritis(Korean Soc Otorhinolaryngol, 2015) Akdag, Mehmet; Ucmak, Derya; Ozkurt, Fazil Emre; Bozkurt, Mehtap; Akkurt, Zeynep Meltem; Topcu, IsmailObjectives. The aim of this study was to investigate hearing and outer cells function in patients with psoriatic arthritis. Our investigation was a prospective case control study. Methods. A total of 31 psoriatic arthritis patients (62 ears) and 31 healthy control subjects (62 ears) were enrolled in the study. We investigated hearing changes of patients and controls via pure tone audiometry, speech discrimination scores, tympanometry, acoustic reflex, and transient product otoacoustic emission. Results. The mean age of psoriatic arthritis patients was 36.1 +/- 8.5 years (range, 14 to 62 years). The average age of the control group was 37.9 +/- 8.1 years (range, 16 to 62 years). There were statistically significant differences between pure tone audiometry in all frequencies and right and left emission at the 4.0 and 1.0 in psoriatic arthritis patients versus controls (P < 0.05). This difference was evident, especially at high frequencies. There was no statistically significant difference between the ages and genders of the patient and control groups (P > 0.05). Both audiological and otoacoustic emissions were not significantly different between right and left ear (P > 0.05). Conclusion. Based on the audiological and otoacoustic findings; it is likely that the cochlear outer hair cells become subtly damaged in psoriatic arthritis patients, consequently leading to changes in hearing thresholds. These data suggest that it is important to screen psoriatic arthritis patients for hearing changes with otoacoustic emissions and audiologic tests regularly.Öğe THE HISTOMORPHOLOGIC EFFECTS OF HYPERBARIC OXYGEN THERAPY ON SUBMANDIBULAR, THYROID GLANDS AND TRACHEA(Diagnosis Press Ltd, 2013) Akdag, Mehmet; Gul, Aylin; Bakir, Salih; Ozkurt, Fazil Emre; Alabalik, Ulas; Topcu, IsmailThe aim of this experimental study was to investigate the efficacy of hyperbaric oxygen (HBO) therapy in the neck region of rats based on morphologic changes induced in the exocrine and endocrine glands and trachea. Samples of submandibular glands, thyroid gland and trachea were collected following sacrifice and neck dissection of the animals. The samples were processed for light microscopy and morphometric analysis. HBO administered rats were placed into a large pressure chamber and received 100 % oxygen at 253.3125 kPa (2.5 ata) for 60 min per day for a period of seven days. HBO-treated rats showed no statistically significant differences from the control group, according to the analysis of the histopathological scores (p = 0.930). HBO could probably be considered as neither helpful, nor harmless, on the submandibular glands, thyroid glands and trachea in rats.Öğe Long-term effect of radiofrequency turbinoplasty in nasal obstruction(Taylor & Francis Ltd, 2014) Akdag, Mehmet; Dasdag, Suleyman; Ozkurt, Fazil Emre; Celik, Mehmet Yusuf; Degirmenci, Aydin; Demir, Huseyin; Meric, FarukThe aim of this retrospective study is to investigate long term (two years) effect of radiofrequency tissue volume reduction (RFVTR) on nasal obstruction associated with inferior turbinate hypertrophy, which is not respond to medical treatment. This retrospective study carried out on 98 patients with nasal obstruction treated by RFVTR (56 males, 42 females, from 17 to 70 years of age). Visual analogue scales (VAS) and nasal endoscopic view score (NES) were used for nasal obstruction to evaluate the efficacy of the treatment. Results of one, three, six, twelve and twenty four months after RFVTR treatment were compared with pre-exposure values. Turbinate edema and nasal obstruction in the treated patients were recovered after one month of treatment (p < 0.01). Maximum improvement were determined at the end of third month (p < 0.01). However, eficacy of RFVTR declined twelve months after treatment. Final percentage of imrovement was found as 51 % at the end of second year of treatment because of co-factors was not eliminated by some patients. On the other hand, no statistical significant difference was observed between the right and left nasal cavity (p < 0.001). In conclusion, the result of this study indicated that patients who have not eliminate co-factors such as smoking, obesity and allergic rhinitis may need re-application of RFTVR. However, further studies on radiofrequecy energy level and elimination of other co-factors are necessary to illuminate the eficacy of RFVTR.Öğe Managment of orbital complications of sinusitis(Consel Brasil Oftalmologia, 2014) Ozkurt, Fazil Emre; Ozkurt, Zeynep Gursel; Gul, Aylin; Akdag, Mehmet; Sengul, Engin; Yilmaz, Beyhan; Yuksel, HarunPurpose: We reported on the clinical approaches of ophthalmology and otorhinolaryngology departments in the treatment of the orbital complications of sinusitis. We also included an in-depth literature review. Methods: We retrospectively reviewed the medical files of 51 patients from January 2008 to January 2014. The records were evaluated for age, gender, type of orbital complications, symptoms, predisposing factors, imaging studies, medical and surgical management, culture results, and follow-up information. SPSS version 15.0 software (Statistical Analysis, The Statistical Package for Social Sciences Inc, Chicago, IL) was used for the statistical analysis. Results: Fifty-one patients met the criteria, with available medical records, for the study (29 male, 22 female). Thirty-two (62.7%) were diagnosed with preseptal cellulitis and 19 (37.3%) with postseptal cellulitis. After a detailed evaluation, 15 were diagnosed with a subperiosteal abscess (SPA), and 4 were diagnosed with orbital cellulitis. The age and gender was similar for the two groups. Five patients with medial SPA were treated with endoscopic sinus surgery, one patient with inferior SPA was treated with external surgery, and six patients with other localizations were treated with a combination of endoscopic sinus surgery and external surgery. All patients presented with periorbital erythema and edema. The length of hospitalization and duration of symptoms were similar in both groups. Visual acuity was between 1/10 to 10/10 (mean 7/10) and statistically significant for preseptal and postseptal cellulitis groups (p<0.001). All patients received intravenous antibiotics upon the first day of admission. Conclusion: Orbital complications of acute sinusitis required intensive follow-up and a multidisciplinary approach. A contrast-enhanced paranasal sinus computerized tomography (CT) scan can detect the extent of the infection. An initial trial of intravenosus (IV) antibiotics may be appropriate when close monitoring is possible. Surgery may be indicated when there has been no improvement within 48 hours of intravenous treatment, loss of visual acuity (under 8/10), and a non-medial abscess.Öğe The Protective Effect of Intratympanic Dexamethasone on Streptomycin Ototoxicity in Rats(Sage Publications Inc, 2017) Gul, Aylin; Sengul, Engin; Yilmaz, Beyhan; Ozkurt, Fazil Emre; Akdag, Mehmet; Keles, Aysenur; Topcu, IsmailThe purpose of this experimental study was to investigate the protective role of intratympanically administered dexamethasone on the inner ears of rats that were exposed to streptomycin ototoxicity. Twenty-four adult Wistar albino rats were separated into 4 groups: Group 1 (only streptomycin), Group 2 (only intratympanic dexamethasone), Group 3 (streptomycin and intratympanic dexamethasone), and Group 4 (streptomycin and intratympanic saline). All rats were evaluated with distortion product otoacoustic emissions (DPOAE) tests before the start of treatment and on the day it ended. On the 45th day, after the final DPOAE tests, animals of all groups were sacrificed under general anesthesia. The differences between the amplitudes of DPOAE results were determined, and hearing results were statistically analyzed. Also, the cochleas of each rat were histopathologically evaluated under a light microscope with hematoxylin and eosin staining. In the intratympanic dexamethasone group it was observed that cochlear hair cells were mostly protected. No significant difference was seen between the DPOAE results before and after treatment (p > 0.05). On the other hand, loss was observed in the hearing functions and hair cells of the rats that received streptomycin and streptomycin plus intratympanic saline (p < 0.05). In the streptomycin plus intratympanic dexamethasone group, the cochlear hair cells were partially protected. A significant difference was observed when the DPOAE results (DP-grams) of the streptomycin plus intratypmanic dexamethasone group were compared to those of the streptomycin plus intratympanic saline group (p < 0.05). After the experimental study, ototoxic effects of the administration of streptomycin and intratympanic dexamethasone were observed on the rats' cochlear hair cells. We conclude that intratympanic dexamethasone has protective effects against this cochlear damage in rats.Öğe Rare Head and Neck Trauma due to Construction Nail: Case Report(Aves, 2014) Aguloglu, Bulent; Gul, Aylin; Ozbay, Musa; Ozkurt, Fazil Emre; Cetin, Muzeyyen; Topcu, IsmailIntroduction: Oropharyngeal penetrating trauma is encountered more often in children under the age of 5 due to lack of their selfprotection. Case Report: In this paper, a 2-year-old girl who had penetrating oropharyngeal trauma after falling on a construction nail was presented. As a consequence of the physical examination and radiological examination applied to the patient, it was seen that the foreign body reached the clivus in the base of the skull, through the nasopharynx, passing by the hard and soft palate junction. In the status of the patient, who was operated on, no additional clinical aspects or neurological or lack of visual activity was observed in the post-operative period. As there was no complication during the follow-ups, the patient was discharged with recommendations. Conclusion: Oropharyngeal penetrating trauma should be careful in terms of mortality and morbidity due to the proximity to vital organs.
