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    ASSOCIATION OF DEMODICOSIS WITH ACNE ROSACEA
    (Professional Medical Publications, 2010) Cengiz, Tas Z.; Yilmaz, Hasan; Akdeniz, Necmettin; Cicek, Mutalip; Ozkol, Halil; Calka, Oemer
    Objectives: Demodex spp of humans are encountered frequently all over the world. The role of these parasites is controversial in the causation of skin diseases. This study was carried out to determine the prevalence and the association of Demodex spp with acne rosacea. Methodology: The study was conducted between the years of 2005-2008 in the output clinic of Dermatology and Parasitology Laboratory of Health Research and Training Hospital of Yuzuncu Yil University. One hundred two patients (patient group) composing of 59 females and 43 males with acne rosacea and randomly selected 50 healthy subjects (control group) were examined for Demodex spp. Twenty seven patients were under the age of 35, and 75 patients were aging 35 years old and over. Samples were plucked out from surface of nose and forehead of patients with acne rosacea and healthy subjects by standardized surface skin biopsy (SSSB) method in the Laboratory. The preparations prepared in Hoyer solution were examined under 4X and 10X objectives of light microscope. Results: The detected parasites were higher in the patient group with acne rosacea (67.65%) than the control group (6%), in females (76.27%) than males (55.81%) and in patients aging 35 years old and over (74.67%) than the patients under 35 years of age (48.15%). Significant relationships were detected between acne rosacea and demodicosis, sex and demodicosis, and age and demodicosis (p<0.001, p<0.05 and p<0.05, respectively). Conclusion: It was concluded that there is a relationship between the demodicosis and acne rosacea, and dermatologists should take into consideration the Demodex spp. in the etiology of acne rosacea.
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    Öğe
    The Prevalence of MEFV Gene Mutations in Rheumatoid Arthritis Patients Inhabiting the Van Province and Surroundings
    (Baycinar Medical Publ-Baycinar Tibbi Yayincilik, 2014) Ozkol, Halil; Yildirim, Ibrahim Halil; Tuluce, Yasin; Ediz, Levent; Delen, Veysel; Gulcu, Elif
    Objective: An inhibitory protein of inflammation pyrin/marenostrin is encoded by the Mediterranean fever (MEFV) gene. Mutations of this gene are known to cause familial Mediterranean fever (FMF) disease. A relation between mutations of the MEFV gene and rheumatic diseases was also suggested. The aim of the present study was to investigate the frequency of four common mutations of the MEFV gene in 110 rheumatoid arthritis (RA) patients and 98 healthy controls (HC) inhabiting a region of eastern Turkey. Material and Methods: DNA extraction was realized by salting out method from peripheral blood lymphocytes of all subjects included in the study. Polymerase chain reactions (PCR) amplification of exon 10 was performed by the appropriate primers, and single-nucleotide polymorphisms (SNPs) were detected by specific restriction endonucleases recognizing the mutational DNA or wild-type DNA regions. Results: Mutation frequency of RA patients was higher than in HC, but this result was not statistically significant (p>0.05). Conclusion: The MEFV mutation rate of RA patients living in eastern Turkey was not significantly different from HC. Further studies are needed to investigate other gene mutations that may affect RA etiopathogenesis.