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    Coexistence of a cerebellopontine epidermoid cyst with a pituitary adenoma
    (Elsevier Science Bv, 2002) Kemaloglu, S; Ozkan, U; Ziyal, I; Bukte, Y; Ceviz, A
    We report on an 18-year-old girl with the coexistence of an epidermoid cyst in the cerebellopontine angle (CPA) with a pituitary adenoma. The clinical course and histopathological characteristics were reviewed. The patient presented with headache, vision loss and amenorea. Computerised tomographic (CT) scan and magnetic resonance imaging (MRI) examinations demonstrated a solid sellar lesion with supra-sellar extension. There was another mass lesion in the CPA with prepontine extension. The tumours were removed surgically. Histopathological examination revealed an epidermoid cyst in the prepontine area and a pituitary adenoma in the sellar region. This has been the second case to be reported in the literature with the coexistence of ail epidermoid cyst and a pituitary adenoma. (C) 2002 Elsevier Science B.V. All rights reserved.
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    Growth rate of cerebral hydatid cyst, with a review of the literature
    (Springer, 2001) Kemaloglu, S; Ozkan, U; Bükte, Y; Acar, M; Ceviz, A
    This extremely rare case was one of secondary solitary cerebral echinococcosis associated with possible cerebral thromboembolism. A 7-year-old girl living in a rural area was admitted to our hospital with a history of headache, right-sided hemiparesis, and dysphasia. She had been treated 6 months previously for a cerebral infarct, diagnosed from sudden altered consciousness and a myoclonic generalised convulsion. The growth rate determined for the cerebral hydatid cyst was about 4.5 cm during the 6-month period. In children a parasitic cyst can be the source of a cerebral embolus, particularly in areas where hydatid disease resulting from cardiac echinococcosis is endemic.
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    Prevention of spinal epidural fibrosis by recombinant tissue plasminogen activator in rats
    (Nature Publishing Group, 2003) Kemaloglu, S; Ozkan, U; Yilmaz, F; Nas, K; Gur, A; Acemoglu, H; Karasu, H
    Study design: A randomized-controlled experimental study was conducted to investigate the effectiveness of recombinant tissue plasminogen activator (rt-PA) on postlaminectomy epidural fibrosis in rats. Setting: Diyarbakir, Turkey. Methods: In a rat model, allowing objective histopathological quantification, the postoperative epidural scar formation was investigated and the potential of local rt-PA in preventing the production of epidural fibrosis was assessed. Rats were randomly allocated to local rt-PA (12 rats) or control (12 rats). Results: Findings suggest a beneficial effect of rt-PA in decreasing the epidural. fibrosis following laminectomy when compared with control groups for all investigated parameters such as intermuscular scar (P = 0.04), middle scar (P = 0.001), deep scar (P = 0.001) and dural adhesion (P = 0.01) except new bone formation. The presence of arachnoiditis was less in treatment group (P = 0.01). Conclusion: In rats, the topical thrombolysis with rt-PA is safe and efficacious in preventing postlaminectomy epidural. fibrosis. This Thrombolytic therapy with rt-PA after spine surgery may come to play an important role in the prevention of epidural fibrosis and arachnoiditis.
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    Treatment of subdural empyema by burr hole
    (Israel Journal Med Sciences, 1996) Ak, HE; Ozkan, U; Devecioglu, C; Kemaloglu, MS
    Subdural empyema, a collection of pus in the space between the dura and arachnoid, is a rare type of intracranial infection. We report on 23 patients, aged 8 months to 70 years, with subdural empyema who were treated in our clinic between 1989 and 1994. The sources of subdural empyemas were meningitis in five patients, middle ear in five, trauma in four, paranasal sinus in three, complications of surgery and subdural tap in four, and unknown in two patients. The common presentations were headache, focal neurologic deficit, fever, vomiting, seizures, and neck stiffness. Diagnosis was achieved by computerized tomography and neurologic examinations in all cases. Treatment was effected by burr hole or small craniotomy with catheter drainage, and antibiotics were administered to all patients. The mortality rate was 8.7%; the remaining patients made a good recovery without sequelae. We therefore recommend burr hole with catheter drainage plus antibiotics as a method of treating subdural empyema.