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    Clinical features and patency rates of Remedy® biodegradable peripheral stents
    (Clinics Cardive Publ Pty Ltd, 2016) Tiryakioglu, Selma Kenar; Tiryakioglu, Osman; Karahan, Oguz; Demirtas, Sinan; Gokalp, Fatih; Erkoc, Kamuran; Ozkan, Hakan
    Objective: The aim of this study was to investigate the mid-term results of Remedy (R) biodegradable stents, which have recently come into use for lower-extremity arterial occlusive disease. Methods: Sixty-five patients, who underwent surgical intervention in various cardiovascular surgery clinics throughout Turkey, were included in the study. The total number of stents used was 92. The mean age of the patients was 64.11 +/- 24.13 years (20-82), and 16 (24.6%) were female. The mean number of stents per patient was 1.42, and 70.7% of the lesions were TASC type A. Patients were followed for a mean of 32 months. Sixty-five patients underwent a control examination using either digital subtraction angiography or colour Doppler ultrasonography. In-stent restenosis was defined as >= 50% stenosis in the stent area in asymptomatic patients. The procedure was repeated if the degree of stenosis was >= 70%. Results: During the follow-up period, restenosis (>= 50% stenosis) was observed in seven patients (10.7%). The patency rate after secondary intervention was 100%, and there was no loss of limbs in any patient. Restenosis was observed in six patients with superficial femoral artery stents, and in one patient with a popliteal arterial stent. Conclusion: Our experience shows that Remedy (R) biodegradable peripheral stents were safe and effective in our cohort of patients, with acceptable patency rates.
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    Effects of caffeic acid phenethyl ester on wound healing of nasal mucosa in the rat: an experimental study
    (W B Saunders Co-Elsevier Inc, 2014) Kinis, Vefa; Ozbay, Musa; Akdag, Mehmet; Alabalik, Ulas; Gul, Aylin; Yilmaz, Beyhan; Ozkan, Hakan
    Purpose: Wound healing of the nasal mucosa is a highly complex process that restores the anatomical and functional integrity of tissue that has been exposed to trauma. In this experimental study, our aim was to use histopathological examination to investigate the effects of caffeic acid phenethyl ester on the wound healing of rat nasal mucosa after mechanical trauma. Materials and methods: The rats were randomly divided into 3 experimental groups: a non-treated group (n = 7), a control saline group (n = 7) and a caffeic acid phenethyl ester group (n = 7). The non-treated group received no treatment for 15 days. The second group was administered saline (2.5 mL/kg, intraperitoneal) once a day for 15 days. The third group received caffeic acid phenethyl ester intraperitoneally at a dose of 10 mu mol/kg once a day for 15 days. At the beginning of the study, unilateral mechanical nasal trauma was induced on the right nasal mucosa of all rats in the three groups using a brushing technique. Samples were stained using hematoxylin and eosin solution and were examined by a pathologist using a light microscope. Results: The severity of inflammation was milder in the caffeic acid phenethyl ester group compared with that in the non-treated and saline groups (P < 0.05). The subepithelial thickness index was lower in the experimental group (P < 0.05). Goblet cell and ciliated cell loss was substantially reduced in the experimental group compared with the non-treated and saline groups (P <0.05). Conclusions: Caffeic acid phenethyl ester decreases inflammation and the loss of goblet cells and ciliated cells. Therefore, caffeic acid phenethyl ester has potential beneficial effects on the wound healing of nasal mucosa in the rat. (C) 2014 Elsevier Inc. All rights reserved.
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    THE EFFICACY OF DOPPLER ULTRASOUND ON CHRONIC SUPPURATIVE OTITIS MEDIA
    (Carbone Editore, 2015) Gul, Aylin; Akdag, Mehmet; Ozkurt, Fazil Emre; Aguloglu, Bulent; Ozkan, Hakan; Akturk, Adem; Yilmaz, Beyhan
    Aims: The diagnostic techniques used in the diagnosis of lateral sinus thrombosis are invasive and pose a risk of stroke. For this reason, we aimed to evaluate the efficiency of Doppler ultrasonography, a simple, fast, and non-invasive technique in this field. Materials and methods: Patients presenting at our clinic with one-sided, chronic suppurative otitis media were included in the study. Internal jugular vein and internal carotid artery Doppler tests were conducted on the patients. The healthy ears of the patients were used as the control group. The values were compared statistically. Results: A total of 40 patients were included in the study 17 male (42.5%) and 23 female (57.5%). Seventeen patients had suppurative otitis media with cholesteatoma, and 23 patients had suppurative otitis media without cholesteatoma. According to Doppler ultrasonography parameters, no statistically significant differences were observed. However, when the chronic suppurative otitis media patients were compared to those without cholesteatoma, the internal jugular vein diameter was found to be reduced significantly in the group with cholesteatoma (p=0.047). Conclusion: The results of our study suggest that Doppler ultrasonography can be considered as a useful, fast, easy, and non-invasive method in the prognosis of cases with suspected lateral sinus thrombosis.