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    Evaluation of Retinal Nerve Fiber Layer Thickness with Optical Coherence Tomography in Type 1 Diabetes Mellitus Patients
    (Ortadogu Ad Pres & Publ Co, 2011) Gonul, Saban; Ozkagnici, Ahmet; Ozturk, Banu Turgut; Kerimoglu, Hurkan; Sahin, Alparslan
    Objective: To evaluate retinal nerve fiber layer (RNFL) thickness changes of type 1 diabetes mellitus (DM) patients with and without diabetic retinopathy (DR). Material and Methods: One hundred-eighteen patients with type 1 DM and 49 age-matched control subjects were enrolled in the study. Ninety eight of 118 diabetic patients with DR were assigned as group 1 and the remaining 20 patients without DR were labeled as group 20 (n = 98). The RNFL thickness of all subjects were measured using optical coherence tomography (OCT). Results: The study included 118 type 1 DM patients with a mean age of 18.77 +/- 8.80 years. The mean age of 49 subjects in the control group was 18.71 +/- 5.72 (range 7-40) years. The mean RNFL thickness was 103.79 +/- 6.45 mu m in the control group, 100.00 +/- 11.93 mu m in group 1 and 85.59 +/- 19.81 mu m in group 2. The decrease in group 2 was found statistically significant (p < 0.001). The mean RNFL thickness in the superior, nasal, inferior and temporal quadrants were less in group 1 compared to controls, however this data was not statistically significant (p = 0.274, p = 0.149, p = 0326, p = 0783, respectively). In group 2, the RNFL thickness revealed a statistically significant decrease in all quadrants (p < 0.001) except temporal quadrant (p = 0.396). The mean duration of DM was significantly longer in group 2 (153.80 +/- 70.35) compared to group 1(60.76 +/- 50.41 months) (p < 0.001). However, there was no correlation between the RNFL thickness and the duration of DM. Conclusion: The RNFL thickness of patients with type 1 DM was found less compared to control subjects. This was more prominent in patients with established retinopathy (group 2). These findings suggested that the RNFL thickness measurement with the aid of OCT may be used as an adjunctive diagnostic tool for early diagnosis of DR.
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    Nanophthalmos and situs inversus totalis
    (All India Ophthalmological Soc, 2012) Sahin, Alparslan; Oltulu, Refik; Kivrak, Ali S.; Ozkagnici, Ahmet
    Nanophthalmos is characterized by short axial length, high hypermetropia, thick sclera and a normal-sized crystalline lens. Situs inversus totalis is the mirror image of the normal morphology of the thoracic and abdominal viscera. To the best of our knowledge this is the first report of a nanophthalmic patient with situs inversus totalis. Therefore, we would like to invite the attention of our colleagues to our case and underline the importance of the systemic examination of the nanophthalmic patients to detect systemic malformations and visceral transpositions.