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    Growing of Hypericum scabroides Robson & Poulter by micropropagation and investigation of hypericin contents
    (Elsevier Sci Ltd, 2011) Asan, Hilal Surmus; Ozen, Hasan Cetin
    [Abstract Not Available]
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    A guaiane diol from Actinolema eryngioides
    (Natural Products Inc, 2008) Ozen, Hasan Cetin; Pollastro, Federica; Appendino, Giovanni
    The seeds from the Umbelliferous Anatolian plant Actinolema eryngioides Fenzl afforded, as a major constituent, the guaiane diol 1, the unusual hydroxylation pattern of which (C-4 and C-7) was established by spectroscopic means.
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    Öğe
    STAT-3 Inhibitory Bisabolanes from Carthamus glaucus
    (Amer Chemical Soc, 2012) Taglialatela-Scafati, Orazio; Pollastro, Federica; Cicione, Lavinia; Chianese, Giuseppina; Bellido, Maria Luz; Munoz, Eduardo; Ozen, Hasan Cetin
    Apart from a large amount (ca. 2.0%) of alpha-bisabolol beta-D-fucopyranoside (2a), the aerial parts of the Mediterranean weed Carthamus glaucus afforded an unusual triglyceride (E-2-crotonyl-1,3-distearolylglycerol, 7), two lipophilic flavonoids (6a,b), and a series of bisabolane fucopyranosides variously acylated on the sugar moiety (2b-e) or oxidized on the terpenoid core (3, 4a,b, 5a,b). The fucopyranoside 2a is more soluble in polar media and more versatile in terms of formulation than its aglycone [(-)-alpha-bisabolol, 1], an anti-inflammatory cosmetic ingredient in current short supply in its natural form. A comparative investigation of the activity of alpha-bisabolol (1a), the fucopyranoside 2a, and its senecioate 2b on transcription factors involved in inflammation and cancer pathways (NF-kappa B and STAT-3) showed only marginal activity on NF-kappa B inhibition for all compounds, while STAT-3 was inhibited potently by the fucoside 2a and, to a lesser extent, also by a-bisabolol. These observations qualify 2a as an easily available compound, both as an apoptotic lead structure and as a potential alternative to natural a-bisabolol (1) for pharmaceutical and/or cosmetic development.