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    The effect of the selective cyclooxygenase II inhibitor parecoxib on renal morphology and function in acute unilateral ureteral obstruction
    (Acta Medica Mediterranea, 2014) Tutus A.; Deliktas H.; Gedik A.; Gezici A.; Ozekinci S.; Sahin H.
    Objectives: This experimental study aimed to examine the efficacy of parecoxib in the treatment of kidney obstruction. The histopathological and scintigraphic effects of the selective cyclooxygenase II (COX-II) inhibitor parecoxib on renal morphology and function were determined following surgically induced unilateral ureteral obstruction. Materials and methods: The study included 20 male Sprague-Dawley rats that were assigned to 2 groups of 10 each. The rats underwent diethylenetriamine pentaacetic acid (DTPA) renal scintigraphy to calculate basal glomerular filtration rate (GFR) values at the beginning of the study. The left ureters in groups 1 and 2 were ligated distally. The rats in group 2 received parecoxib 5 mg·kg-1·d-1 for 21 d post surgery, whereas those in group 1 received nothing. At the end of postoperative d 21 DTPA renal scintigraphy was repeated in all the rats before undergoing bilateral nephrectomy. All kidneys were evaluated histologically. Results: Histologically, there were no differences between the right kidneys in groups 1 and 2, whereas the occurrence of cortical congestion, glomerular congestion, interstitial inflamation + congestion, and interstitial fibrosis was significantly lower in the left kidneys in group 2 than in those in group 1 (cortical congestion: P = 0.005; glomerular congestion: P = 0.03; interstitial inflamation + congestion: P = 0.01; interstitial fibrosis: P = 0.005). Scintigraphically, left kidney and right kidney GFR values in group 2 were higher than those in group 1; the difference was significant (left kidneys: P = 0.001; right kidneys: P = 0.009). Conclusion: Histopathologically and scintigraphically, kidney function was preserved at the highest level in group 2. Parecoxib treatment was effective in preserving renal function in the obstructed and non obstructed (contralateral) kidneys, and can be administered during the obstruction period until the time radical treatment of obstruction can be performed.
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    Evaluation of cystic echinococcosis cases given a histopathologic diagnosis from 2002 to 2007 in Diyarbakir
    (2009) Ozekinci S.; Bakir S.; Mizrak B.
    Echinococcosis is a common parasitic disease manifesting as cyst formation in humans and animals, caused by the platyhelminth, Echinococcosis and it is an important health problem in our country. The aim of this study was to acquire knowledge about the topographic features, the prevalence of cystic echinococcosis and to predict its frequency in the Diyarbakir region. From 2005 to 2007, 234 patients who had been given a histopathological diagnosis of cystic echinococcosis were analysed retrospectively. Based on the pathological records age, sex and location of the parasite were evaluated, and if a patient had the parasite in more than one location, it was counted as one. Female patients constituted 60.25% of the cases, and males, 39.74%. The average age of the patients was 27.01 years (28.2 years in females and 25.3 years in males). The most frequent location of echinococcus was in the liver (44.01%), and the second in the lung (31.19%). In general the characteristics of the patients correlated with the characteristics of previous literatures results but the age of the patients when diagnosed was earlier than that previously reported in the literature. Cystic echinococcosis was found to be an important public health problem in Diyarbakir region. For the eradication of echinococcosis it is necessary to get reliable data, and to implement an appropriate eradication program.
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    Vesiculobullous dermatomyositis with sensory motor neuropathy
    (Pulse Marketing and Communications LLC, 2013) Ayhan E.; Baykara S.N.; Ozekinci S.; Aytekin S.
    A 74-year-old man presented with muscle weakness in both legs for a duration of 2 months. Physical examination revealed periorbital edema and erythema, erythema on the neck and chest, erythematous papules on the proximal-distal interphalangeal and metocarpophalangeal joints, crusted plaque lesions on the thighs and around the knees, and bullous and ulcerated lesions in the antecubital and popliteal fossae (Figure 1A and 1B). Some bullous lesions were intact and some were ulcerated. There was severe edema especially in the upper extremities. He had a history of 15-kg weight loss for 4 months. Laboratory findings were remarkable for a white blood cell count of 16.0 K/UL (4.60–10.20 K/UL), a C-reactive protein of 6.93 mg/dL (0–0.5 mg/dL), an erythrocyte sedimentation rate of 50 mm/h (8–15 mm/h), an aspartate aminotransferase level of 213 U/L (10–40 U/L), a lactate dehydrogenase of 447 U/L (<225 U/L), and a creatine kinase level of 1733 U/L (29–200 U/L). Results from antinuclear antibody at 1:320 titers and anti-smooth muscle antibody were positive. Results from anti-SS A/SS B antibodies, anti Jo-1 antibody, U1-snRNP antibody, and anti-ds DNA antibody tests were negative. A skin biopsy specimen obtained from the right antecubital fossa showed minimal orthokeratosis and subepidermal detachments. There was marked edema in the dermis and lymphocyte infiltration around the skin appendages (Figure 2). Direct immunofluorescence studies demonstrated scattered staining for C3 and IgM at the basal membrane zone. Results for IgG, IgA, and fibrin staining were negative. Muscle biopsy from left deltoid muscle was performed and some muscle fibers were demonstrated to be atrophied. There was remarkable difference between muscle fiber diameters. With Masson staining, there was increased connective tissue and no inflammation. Electromyography (EMG) showed a myogenic pattern. Nerve conduction studies showed tibial, median, ulnar, peroneal motor neuropathy, and median, ulnar, and sural sensory neuropathy. Based on these findings, diagnosis of vesiculo-bullous dermatomyositis (DM) was made. Further investigation of esophagogastroduodenoscopy with biopsy revealed ulcerated lesions on antrum and corpus and these were assessed as Helicobacter pylori– negative atrophic chronic gastritis. No pathologic findings were described on chest, abdomen, and pelvic tomography. Levels of tumor markers were within normal ranges. Overall, no sign of malignancy was detected. Methyl prednisolone treatment of 1 mg/kg/d was started; however, new bullous lesions erupted while the original lesions were healing. © 2013 Pulse Marketing & Communications, LLC.