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Öğe Brucellosis Seroprevalance on Goats, Sheep, Cows and Man who are under Risk in Diyarbakir Region(Medwell Online, 2012) Arserim, N. B.; Ozekinci, T.; Ceylan, A.; Tel, O. Y.; Keskin, O.; Vural, A.The aim of this study was to determine the prevalence of brucellosis in sheep, goats, cows and human who are at risk in Diyarbakir region. From ten locations obtained in Diyarbakir, blood samples were collected from sheep, goats and cows belonging to different herds and man who are at risk between 2007 and 2009 years. The blood samples were tested using the Microagglutination (MAT) technique. Seropositivity by using MAT technique on the collected blood samples were positive on 60 (35.2%) of 170 sera taken from the veterinarian, slaughterhouse staff, butchers and growers. Also the positivity rates were 20 (2.9%) of 680, 5 (0.7%) of 725 and 25 (4.3%) of 575 for sera samples taken from cows, sheep and goats, respectively. Consequently, seropositivity is obtained high for animals and individuals who are under risk according to the other regions in Turkey. It is considered that brucellosis can be decreased by informing the individuals who are under risk about the infection of this illness and the works about this subject.Öğe COMPARISON OF INTERFERON-GAMMA RELEASE ASSAY VERSUS TUBERCULIN SKIN TEST FOR LATENT TUBERCULOSIS SCREENING IN HEMODIALYSIS PATIENTS(Taylor & Francis Ltd, 2009) Ates, G.; Ozekinci, T.; Yildiz, T.; Danis, R.Early diagnosis and proper treatment of latent tuberculosis infection (LTB1) in patients with end stage renal diseases (ESRD) is critical to reduce increased reactivation risk of LTB1. However; this condition is known to decrease responsiveness to the tubercidin skin test (TST). A new, diagnostic test [QuantiFERON-TB Gold in-tube (QFT-GIT)] has been developed using mycobacterium tuberculosis specific antigens for the identification of LTB1. We aimed to evaluate the two test methods among hemodialysis patients for their diagnostic usefulness. We performed a cross-sectional comparison study on 275 ESRD recruits tested for LTB1 using the TST and QTF-GIT. Valid TST and QFT-GIT results were available for 259 and 246 patients, respectively. Overall, 46.7% of 246 patients were tested positive for the QTF-GIT and 35.5% of 259 were found to be TST positive. The QTF-GIT but not TST results were correlated with the history of tuberculosis: conversely, QTF-GIT and TST results were not associated with contact to tuberculosis. Moreover, QTF-GIT test generated indeterminate results in 10.4% of subjects. The concurrence between the two test methods was poor (67.8%, kappa = 0.34). Inconsistent results, most of which were, tested as TST negative/QTF-GIT positive were observed in 32.2% patients. The present results suggest that the QTF-GIT is more sensitive than TST in the detection of LTB1 among renal dialysis patients. Nevertheless, large longitudinal studies are required for more accurate results.Öğe Comparison of tuberculin skin test and a specific T-cell-based test, T-Spot™.TB, for the diagnosis of latent tuberculosis infection(Sage Publications Ltd, 2007) Ozekinci, T.; Ozbek, E.; Celik, Y.There is substantial evidence that the detection of T cells specific for the proteins ESAT-6 and CFP-10 using the ex vivo enzyme-linked immunospot technique is a marked improvement on the existing tuberculin skin test (TST). This new technique, which detects,gamma-interferon-producing T cells, is now available as the commercial assay, T-Spot (TM).TB. We compared the T-Spot (TM).TB test with the TST for the diagnosis of latent tuberculosis infection (LTBI) in different groups of subjects. Significant accordance (85.7%) between the tests was found in subjects with active lung tuberculosis and in tuberculosis clinic and laboratory personnel (63.6%) but accordance was lowest and not significant amongst house contacts of tuberculosis patients (53.6%). We conclude that, in countries where vaccination is routinely performed, the T-Spot (TM).TB test is a useful diagnostic test for LTBI in highrisk groups when carried out either together with the TST and/or to confirm the TST result.Öğe HEPATITIS C VIRUS GENOTYPES ARE CHANGING IN THE SOUTHEAST OF TURKEY(Diagnosis Press Ltd, 2009) Ozbek, E.; Ozekinci, T.; Mese, S.; Atmaca, S.Hepatitis C virus (HCV) infection is a frequent cause of acute and chronic hepatitis, and may lead to the development of cirrhosis and subsequently hepatocellular carcinoma. It is estimated that about 150 to 200 million people have been in contact with HCV worldwide, and approximately 85% are chronically infected. HCV is a highly heterogenous virus. At least 6 genotypes and more than 50 subtypes marked with letters (e.g. 1a, 1b, 2a, 2b) of the virus, have been detected worldwide until now HCV genotype 1 was detected as the most common genotype in the studies also done in our country. The aim of this study is to determine the HCV genotypes and reveal the change in HCV genotypes in the South-Eastern region of Turkey. Between April 2007 and October 2008, the study evaluated serum samples of 74 patients (40 women) that were HCV RNA positive determined by polymerase chain reaction (PCR). HCV genotypes were determined with Inno-LIPA method. 5'non-coding region (5'NCR) of HCV-RNA was amplified by reverse transcriptase polymerase chain reaction (RT-PCR) and genotyped by line probes in Inno-LIPA assay. The genotype results of HCV in the serum samples were as follows: 87.8% genotype 1b, 4.1% genotype 1, 2.7%genotype 2, 2.7% genotype 3 and 2.7% genotype 3a. Genotype I was determined predominantly in a total of 68 (91.9%) patients.Öğe Hepatitis C virus genotypes are changing in the southeast of Turkey(Elsevier Science Bv, 2009) Ozbek, E.; Ozekinci, T.; Mese, S.; Atmaca, S.[Abstract Not Available]Öğe Lack of correlation between CRP and hepatitis B viral load in serum of patients with chronic HBV(W B Saunders Co Ltd, 2007) Gedik, M.; Ozekinci, T.; Ozbek, E.; Atmaca, S.; Yilmaz, S.[Abstract Not Available]
