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Öğe Family History in Patients with Bipolar Disorder(Aves, 2016) Ozdemir, Osman; Coskun, Salih; Aktan Mutlu, Elif; Ozdemir, Pinar Guzel; Atli, Abdullah; Yilmaz, Ekrem; Keskin, SiddikIntroduction: In this study, we aimed to better understand the genetic transmission of bipolar disorder by examining the family history of patients. Methods: Sixty-three patients with bipolar disorder and their families were included. The final sample comprised 156 bipolar patients and their family members. An inclusion criterion was the presence of bipolar disorder history in the family. The diagnosis of other family members was confirmed by analyzing their files, hospital records, and by calling them to the hospital. Results: Sixty-five patients were women (41.6%) and 91 were men (58.3%) (ratio of men/women: 1.40). When analyzing the results in terms of the transition of disease from the mother's or father's side, similar results were obtained: 25 patients were from the mother's side and 25 patients were from the father's side in 63 cases. Conclusion: The results of our study support the fact that a significant relationship exists between the degree of kinship and the heritability of bipolar disorder and, furthermore, that the effect of the maternal and paternal sides is similar on the transmission of genetic susceptibility.Öğe Family patterns of psychopathology in psychiatric disorders(W B Saunders Co-Elsevier Inc, 2015) Ozdemir, Osman; Boysan, Murat; Ozdemir, Pinar Guzel; Coskun, Salih; Ozcan, Halil; Yilmaz, Ekrem; Atilla, ErcanOBJECTIVE: Familial loading and crucial outcomes of family history of psychopathology in psychiatric disorders have long been recognized. There has been ample literature providing convincing evidence for the importance of family psychopathology in development of emotional disturbances in children as well as worse outcomes in the course of psychiatric disorders. More often, maternal psychopathology seems to have been an issue of interest rather than paternal psychopathology while effects of second-degree familiality have received almost no attention. In this study, we addressed the relations between affected first- and second-degree relatives of probands and categories of psychiatric disorders. METHOD: Subjects were 350 hospitalized psychiatric inpatients, consecutively admitted to psychiatry clinics in Van, Turkey. Mean age was 34.16 (SD +/- 12) and 51.4% of the sample consisted of male patients. Assessment of psychopathology in psychiatric probands was conducted based on DSM-IV TR. Familial loading of psychiatric disorders amongst first- and second-degree relatives of patients were initially noted primarily relying on patients' retrospective reports, and confirmed by both phone call and following official health records via the Medical Knowledge System. We analyzed the data using latent class analysis approach. RESULTS: We found four patterns of familial psychopathology. Latent homogeneous subsets of patients due to familial characteristics were as paternal kinship psychopathology with schizophrenia, paternal kinship psychopathology with mood disorders, maternal kinship psychopathology and core family psychopathology. CONCLUSION: Family patterns were critical to exerting variation in psychiatric disorders of probands and affected relatives. Probands with a core family pattern of psychopathology exhibited the most colorful clinical presentations in terms of variation in psychopathology. We observed a specificity of intergenerational transmission of psychiatric disorders when family patterns of psychopathology were taken into consideration, even second-degree relatives of psychiatric probands. Copyright (C) 2014 Elsevier Inc. All rights reservedÖğe Mood and metabolic consequences of sleep deprivation as a potential endophenotype' in bipolar disorder(Elsevier, 2013) Aydin, Adem; Selvi, Yavuz; Besiroglu, Lutfullah; Boysan, Murat; Atli, Abdullah; Ozdemir, Osman; Kilic, SultanIt has been commonly recognized that circadian rhythm and sleep/wake cycle are causally involved in bipolar disorder. There has been a paucity of systematic research considering the relations between sleep and mood states in bipolar disorder. The current study examines the possible influences of sleep deprivation on mood states and endocrine functions among first-degree relatives of patients with bipolar disorder and healthy controls. Blood samples were taken at two time points in the consecutive mornings at predeprivation and postdeprivation periods. Participants simultaneously completed the Profiles of Mood States at two time points after giving blood samples. Plasma T3 and TSH levels increased after total sleep deprivation in both groups. Sleep deprivation induced TSH levels were reversely associated with depression-dejection among healthy controls. A paradoxical effect was defected for only the first-degree relatives of the patients that changes in plasma cortisol levels negatively linked to depression-dejection and anger-hostility scores after total sleep deprivation. Plasma DHEA levels became correlated with vigor-activity scores after sleep deprivation among first-degree relatives of bipolar patients. On the contrary, significant associations of depression-dejection, anger-hostility, and confusion-bewilderment with the baseline plasma DHEA levels became statistically trivial in the postdeprivation period. Findings suggested that first-degree relatives of patients with bipolar disorder had completely distinct characteristics with respect to sleep deprivation induced responses in terms of associations between endocrine Functions and mood states as compared to individuals whose relatives had no psychiatric problems. Considering the relationships between endocrine functions and mood states among relatives of the patients, it appears like sleep deprivation changes the receptor sensitivity which probably plays a pivotal role on mood outcomes among the first-degree relatives of patients with bipolar disorder. (C) 2013 Elsevier B.V. All rights reserved.Öğe Sunglasses May Play a Role in Depression(Yerkure Tanitim & Yayincilik Hizmetleri A S, 2012) Alpayci, Mahmut; Ozdemir, Osman; Erdem, Seyfettin; Bozan, Nazim; Yazmalar, LeventProposed causes of winter depression include decrease in amount of sunlight, inability to suppress melatonin production, and finally disruption of circadian rhythms related to sleep/wake cycle in susceptible individuals. Like seasonal effect of sunlight on mood, the mood is also correlated with sunshine hours. The amount of sunlight reaching the brain from the eyes via retinohypothalamic tract is reduced in sunglass users, because sunglasses screen out 75% to 90% of visible light. In people wearing sunglasses, the antidepressant effect of sunlight may be reduced and circadian rhythms may be distorted, possibly leading to the emergence winter depression. Since the sunlight has antidepressant effect and since sunglasses reduce sunlight exposure, we hypothesized that sunglass use may play a role in depression.
