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Öğe Effect of caffeic acid phenethyl ester on myringosclerosis development in the tympanic membrane of rat(Springer, 2015) Kinis, Vefa; Ozbay, Musa; Alabalik, Ulas; Gul, Aylin; Yilmaz, Beyhan; Ozkurt, Fazi Emre; Sengul, EnginMyringosclerosis is hyalinization and calcification of certain areas of the tympanic membrane, especially the fibrous lamina propria layer and appears as white sclerotic lesions. Ventilation tube insertion is one of the most performed operations in the pediatric otorhinolaryngology practice to treat chronic otitis media with effusion. Myringosclerosis is a very common sequela of ventilation tube insertion. In this experimental study, our aim was to show the histopathological effects of caffeic acid phenethyl ester on myringosclerosis development in rat tympanic membrane after myringotomy. The rats were randomly categorized into four experimental groups including the comparison group (n = 4), non-treated group (n = 7), the saline (control) group (n = 7), the caffeic acid phenethyl ester group (n = 7). Non-treated group did not receive any treatment for 15 days. Saline (2.5 mL/kg, intraperitoneal) was administered to the third group once a day for 15 days. Fourth group received caffeic acid phenethyl ester intraperitoneally once a day at a dose of 10 mu mol/kg for 15 days. Myringotomy was performed on the right tympanic membrane of all rats except comparison group using a sterile pick with the help of an operating microscope. Histopathological examination of myringosclerosis formation was done by a pathologist under light microscope. In histopathological analysis of groups, the severity of inflammation was milder in caffeic acid phenethyl ester group compared to non-treated and saline groups (p < 0.05). There was less myringosclerotic plaques in caffeic acid phenethyl ester group than in non-treated and saline groups (p < 0.05). TM thickness measurements were very close to each other in non-treated and saline groups. The tympanic membrane thickness of caffeic acid phenethyl ester group was much thinner than the other two groups (p < 0.05). Caffeic acid phenethyl ester decreases inflammation severity and the formation of myringosclerotic plaques. These two effects resulted in thinner tympanic membranes of rats which were treated with caffeic acid phenethyl ester. As a result, caffeic acid phenethyl ester has potential preventive effects on myringosclerosis development after myringotomy and ventilation tube insertion.Öğe The Effect of Corticosteroid Against Streptomycin Ototoxicity(Lippincott Williams & Wilkins, 2013) Kinis, Vefa; Ozbay, Musa; Bakir, Salih; Sengul, Engin; Yorgancilar, Ediz; Keles, Aysenur; Alabalik, UlasThe aim of this experimental study was to determine the possible protective role of corticosteroid in prevention of streptomycin-induced ototoxicity. Twenty-eight adult Wistar albino rats were divided into 4 groups: control (n = 7), streptomycin (n = 7), corticosteroid (n = 7), and streptomycin + corticosteroid (n = 7). Rats were tested with distortion product otoacoustic emissions (DPOAEs) in the beginning and at the end of the study. The animals in all groups were killed under general anesthesia on the 45th day after the last DPOAE measurements. Hearing results were analyzed statistically to determine differences in amplitudes of DPOAE. In addition, the cochleas of each rat were evaluated by histopathologic and immunohistochemical examination. Significant difference was not observed in cochlear hair cells in the control and corticosteroid groups, whereas severe degeneration of hair cells and increased apoptotic cells were observed in the streptomycin group. Moderate degeneration was observed in the streptomycin + corticosteroid group. The hair cells were partially intact. DP-gram of the streptomycin and streptomycin + corticosteroid groups was significantly deteriorated (P < 0.05). The coadministration of steroids with streptomycin, which has a serious ototoxic effect, did not lead to a limitation of this harmful effect.Öğe Effects of caffeic acid phenethyl ester on wound healing of nasal mucosa in the rat: an experimental study(W B Saunders Co-Elsevier Inc, 2014) Kinis, Vefa; Ozbay, Musa; Akdag, Mehmet; Alabalik, Ulas; Gul, Aylin; Yilmaz, Beyhan; Ozkan, HakanPurpose: Wound healing of the nasal mucosa is a highly complex process that restores the anatomical and functional integrity of tissue that has been exposed to trauma. In this experimental study, our aim was to use histopathological examination to investigate the effects of caffeic acid phenethyl ester on the wound healing of rat nasal mucosa after mechanical trauma. Materials and methods: The rats were randomly divided into 3 experimental groups: a non-treated group (n = 7), a control saline group (n = 7) and a caffeic acid phenethyl ester group (n = 7). The non-treated group received no treatment for 15 days. The second group was administered saline (2.5 mL/kg, intraperitoneal) once a day for 15 days. The third group received caffeic acid phenethyl ester intraperitoneally at a dose of 10 mu mol/kg once a day for 15 days. At the beginning of the study, unilateral mechanical nasal trauma was induced on the right nasal mucosa of all rats in the three groups using a brushing technique. Samples were stained using hematoxylin and eosin solution and were examined by a pathologist using a light microscope. Results: The severity of inflammation was milder in the caffeic acid phenethyl ester group compared with that in the non-treated and saline groups (P < 0.05). The subepithelial thickness index was lower in the experimental group (P < 0.05). Goblet cell and ciliated cell loss was substantially reduced in the experimental group compared with the non-treated and saline groups (P <0.05). Conclusions: Caffeic acid phenethyl ester decreases inflammation and the loss of goblet cells and ciliated cells. Therefore, caffeic acid phenethyl ester has potential beneficial effects on the wound healing of nasal mucosa in the rat. (C) 2014 Elsevier Inc. All rights reserved.Öğe The Effects of Hyperbaric Oxygen Therapy Against Streptomycin Ototoxicity(Derman Medical Publ, 2014) Bakir, Salih; Ozbay, Musa; Kinis, Vefa; Yorgancilar, Ediz; Gun, Ramazan; Gul, Aylin; Alabalik, UlasAim: Hyperbaric oxygen (HBO) is an important adjuvant therapy and being increasingly used in the treatment of various disorders because of having an important antioxidant activity. This experimental study was designed to determine the possible protective effect of HBO therapy on streptomycininduced ototoxicity. Material and Method: Twenty-eight adult Wistar albino rats were divided into four groups: Streptomycin (n= 7), saline (n= 7), HBO (n= 7), and streptomycin plus HBO (n= 7). The HBO administered rats were placed into a large pressure chamber and received 100% oxygene at 2.5 atmosphere absolute for 60 minutes per day in a period of seven days. Rats were tested with DPOAE (Distortion Product Otoacoustic Emissions) in the beginning and the end of study. The animals in all groups were sacrificed under general anesthesia on the seventh day. Biopsy specimens from inner ear were stored for histopathologic examination with hematoxylin and eosin (H& E) under light microscopy. Results: Outer hair cells shown by light microscopic images were mostly preserved in control and HBO group. DPOAE measurements revealed no significant differences between the beginning and the end (p> 0.05). Streptomycin and streptomycin plus HBO treated rats showed loss of hair cells and auditory functions significantly (p< 0.05). Between the groups of streptomycin and streptomycin plus HBO; there was no statistically significance according to the analysis of the histopathological scores and DPgram results (p> 0.05). Discussion: HBO has probably no harmful effect on hair cells. But it seems to be not beneficial in a streptomycin-induced cochlear damage rat model.Öğe Evaluation of Hyperactivity, Attention Deficit, and Impulsivity Before and After Adenoidectomy/Adenotonsillectomy Surgery(Lippincott Williams & Wilkins, 2013) Ayral, Muhammed; Baylan, Muzeyyen Yildirim; Kinis, Vefa; Bez, Yasin; Bakir, Salih; Ozbay, Musa; Yorgancilar, EdizObjective: The objective of this study was to determine the severity of attention deficit, hyperactivity, and impulsivity symptoms in patients with obstructive airway problems scheduled to undergo adenoidectomy or adenotonsillectomy operation. The effects of the surgical treatment on these symptoms will also be investigated in a case-control design. Methods: This prospective study included 63 patients (29 girls, 34 boys) who were operated on at the Department of Otorhinolaryngology, Dicle University Medical School, between January 2010 and May 2011 because of obstructive symptoms caused by adenoid or adenotonsillar hypertrophy. The age range of the patients was between 4 and 13 years. The control group consisted of 33 (17 girls, 16 boys) healthy children. Results: Among the patients, 15 children underwent adenoidectomy because of adenoid hypertrophy; 13 patients had adenotonsillectomy because of adenotonsillar hypertrophy, and the remaining patients underwent adenotonsillectomy related with chronic or recurrent tonsillitis with adenoid hypertrophy. Based on the preoperative data, statistically significant difference was observed between the patient and control groups. The patients' attention deficit, hyperactivity, and impulsivity symptoms preoperatively and postoperatively have shown statistically significant differences. Conclusions: Attention deficit, hyperactivity, and impulsivity symptoms were common among the children who show signs of airway obstruction due to adenotonsillar hypertrophy. Adenoidectomy or adenotonsillectomy operations were both observed to be associated with improvement in these symptoms.Öğe Long-term Follow-up Results of the Patients Suffering from Sudden Hearing Loss(Mediterranean Soc Otology & Audiology, 2013) Akdag, Mehmet; Gul, Aylin; Bakir, Salih; Gun, Ramazan; Ozbay, Musa; Kinis, Vefa; Yorgancilar, EdizObjective: The aim of this follow-up study was to evaluate the time-dependent course of hearing recovery in idiopathic SHL patients. Materials and Methods: Forty-four unilateral idiopathic SHL patients treated with the same standard regimen for 10 days were retrospectively reviewed, then they were invited to return to our hospital for their last visit and last audiogram during the study period. Gender, age, duration and severity of hearing loss, the shape of the audiogram and, the presence of tinnitus were evaluated. Thus, the long-term audiometric data, the final hearing outcome and, the rates of hearing recovery was obtained. Results: There was a significant difference in the degree of hearing loss and the rates of hearing recovery between early stage and long-term follow-up (p<0,001). The most common audiogram shape was flat. Hearing was significantly worse in SHL patients with tinnitus compared to SHL patients without tinnitus (p<0,001). Conclusion: Our results revealed that even if the failure of an initial 10-day course of treatment, a delayed recovery continues and there may still be enough time for complete recovery except profound SHL. Tinnitus on presentation with SHL and profound SHL has been identified as a negative prognostic indicator.Öğe Management of Orbital Complications of Sinusitis in Pediatric Patients(Lippincott Williams & Wilkins, 2013) Kinis, Vefa; Ozbay, Musa; Bakir, Salih; Yorgancilar, Ediz; Gun, Ramazan; Akdag, Mehmet; Sahin, MuhammedThe most common reason of orbital infections is sinusitis. Orbital complications of sinusitis are mostly seen in children. Loss of vision and intracranial infections are among the complications of sinusitis. Prompt diagnosis and treatment is very important in the management of orbital complications. The orbital complication can be in the form of cellulitis or abscess. A retrospective review of 26 pediatric patients with orbital complications due to sinusitis was presented in this study. Of 26 patients, there were 13 cases of preseptal cellulitis, 2 cases of orbital cellulitis, and 11 cases of subperiosteal abscess. We grouped the preseptal and orbital cellulites in one category and the subperiosteal abscess in the other. All patients in the cellulitis group recovered by medical treatment. All the patients were treated by surgical drainage. Early diagnosis and appropriate treatment method are vital for the treatment of orbital complications secondary to sinusitis.Öğe Mental health and quality of life in patients with chronic otitis media(Springer, 2013) Bakir, Salih; Kinis, Vefa; Bez, Yasin; Gun, Ramazan; Yorgancilar, Ediz; Ozbay, Musa; Aguloglu, BulentThe present study focused on the comparison of mental health and quality of life (QoL) between chronic otitis media (COM) patients and the hearing population. The patients with chronic otitis media and healthy control group were enrolled in the study. The duration and severity of the auditory impairment were recorded. In addition to hearing loss (HL), the findings of each patient's other ear disorders (ear discharge and tinnitus) were also recorded. In both the groups, psychological symptom profile and health-related QoL were evaluated and compared using a sociodemographic questionnaire, the Symptom Check List 90-Revised Form (SCL-90-R), and the Short Form-36 (SF-36). According to SCL-90-R, somatization (p < 0.001), interpersonal sensitivity (p < 0.001), depression (p < 0.001), phobic anxiety (p < 0.001), and other subscores, and also global severity index score (p < 0.001) were significantly high in patient group when compared to the control group. The patients with COM reported significantly lower levels of QoL in terms of physical role difficulty (p < 0.001), general health perception (p < 0.004), social functioning (p < 0.001), and mental health (p < 0.017) than those of control subjects. Our results indicated that COM patients with mild or moderate HL have poorer life quality and higher psychological problems. Psychological well being should be also considered in assessment of COM patients in addition to the clinical evaluation and audiological tests.Öğe Neck Masses: Retrospective Analysis of 981 Cases(Ortadogu Ad Pres & Publ Co, 2012) Tanriverdi, M. Halis; Bakir, Salih; Kinis, Vefa; Ozbay, Musa; Toprak, S. Ferit; Firat, UgurObjective: The purpose of this study was to determine and discuss the diagnostic distribution, clinical behaviors and histopathological features of neck masses of patients who were followed-up in our department. Material and Methods: A total number of 981 patients with neck masses, who attended the Department of Ear-Nose-Throat in Dicle University Medical School, between 1992 and 2010, were analyzed retrospectively. Results: Among the 981 cases, 485 (49.5%) had a mass with neoplastic origin, whereas 383 (39%) had inflammatory and 113(11.5%) had congenital neck masses. Approximately 69% of the neoplastic masses were malignant and 31% were benign in nature. The mean ages were 28.26 +/- 7.69 and 11.45 +/- 4.08 years in patients with inflammatory and congenital masses, respectively. The mean age of the patients diagnosed with benign neck masses was 35.5 +/- 5.80 years while the mean age of the patients with malignant masses was 49.22 +/- 11.68 years. Conclusion: Neoplastic masses seem to be the most frequent cause of neck masses. Neck masses, especially in adults should be considered malignant until proven to be benign. In addition, biopsy specimens should not be obtained before a detailed ear, nose and throat examination of the patient.Öğe Neonatal respiratory distress(Galenos Yayincilik, 2012) Bakir, Salih; Kinis, Vefa; Ozbay, Musa; Yolbas, Ilyas; Keles, Ayse Nur[Abstract Not Available]Öğe Patients With Congenital Choanal Atresia Treated by Transnasal Endoscopic Surgery(Lippincott Williams & Wilkins, 2014) Kinis, Vefa; Ozbay, Musa; Akdag, Mehmet; Cetin, Muzeyyen; Gul, Aylin; Yilmaz, Beyhan; Sengul, EnginCongenital choanal atresia (CCA) is defined as a congenital failure in the development of communication between the nasal cavity and nasopharynx in newborns. It is the most common congenital anomaly of nose. Most of the patients presented with unilateral CCA. Neonates with bilateral CCA have severe respiratory distress after birth. Airway control with orotracheal intubation should be done immediately to save the life of neonate with bilateral CCA. After airway control, surgery should be performed as soon as possible. The aim of surgery is to create a patent nasal passage and to prevent restenosis with minimal morbidity. Transnasal endoscopic surgery of CCA has become the most popular treatment method. The retrospective review of 33 patients with CCA was presented in this study. The patients who were diagnosed at the neonate period and operated on in 6 months after birth were grouped as I (neonate). The patients who were diagnosed 6 months after birth were grouped as II (child-young adult). All patients were treated by transnasal endoscopic surgery. Stent were put in all patients to prevent restenosis. Although the restenosis rate was higher in group I (53.8%) than in group II (23.1%), it did not cause a statistically significant difference. Overall success rate of our surgical approach was 61.5%. Despite the surgical developments and many treatment modalities, restenosis is still the most challenging problem in CCA.Öğe The protective role of caffeic acid phenethyl ester against streptomycin ototoxicity(W B Saunders Co-Elsevier Inc, 2013) Bakir, Salih; Ozbay, Musa; Gun, Ramazan; Yorgancilar, Ediz; Kinis, Vefa; Keles, Aysenur; Abakay, AbdurrahmanObjective: The aim of this experimental study was to investigate the efficacy of caffeic acid phenethyl ester (CAPE) in the prevention of streptomycin-induced ototoxicity. Materials and Methods: Thirty-two adult Wistar albino rats were divided into 4 groups: control (n = 8), streptomycin (n = 8), CAPE (n = 8), and streptomycin + CAPE (n = 8). Rats were tested with distortion product otoacoustic emissions (DPOAEs) before drug administration. The animals in all groups were killed under general anesthesia on the 45th day following last DPOAE measurements. Hearing results were analyzed statistically to determine differences in amplitudes of DPOA E. Also, the cochleas of each rat were evaluated by histopathological and immunohistochemical examination. Results: Significant difference was not observed in cochlear hair cells in the control and CAPE groups. In the streptomycin group, severe degeneration of hair cells and increased apoptotic cells were observed. In the streptomycin + CAPE group, although some deteriorations were observed, hair cells were mostly preserved. The DPgram of the streptomycin and streptomycin + CAPE groups was significantly deteriorated (P < .05). The analysis of the DPgram results revealed statistically significant differences between the groups of streptomycin and streptomycin + CAPE (P < .05). Conclusions: Caffeic acid phenethyl ester treatment attenuated hair cells injury in the inner ear, possibly via its antioxidant effect. Prophylactic administration of CAPE for streptomycin ototoxicity ameliorated hearing deterioration in rats. (C) 2013 Elsevier Inc. All rights reserved.Öğe Rare Head and Neck Trauma due to Construction Nail: Case Report(Aves, 2014) Aguloglu, Bulent; Gul, Aylin; Ozbay, Musa; Ozkurt, Fazil Emre; Cetin, Muzeyyen; Topcu, IsmailIntroduction: Oropharyngeal penetrating trauma is encountered more often in children under the age of 5 due to lack of their selfprotection. Case Report: In this paper, a 2-year-old girl who had penetrating oropharyngeal trauma after falling on a construction nail was presented. As a consequence of the physical examination and radiological examination applied to the patient, it was seen that the foreign body reached the clivus in the base of the skull, through the nasopharynx, passing by the hard and soft palate junction. In the status of the patient, who was operated on, no additional clinical aspects or neurological or lack of visual activity was observed in the post-operative period. As there was no complication during the follow-ups, the patient was discharged with recommendations. Conclusion: Oropharyngeal penetrating trauma should be careful in terms of mortality and morbidity due to the proximity to vital organs.Öğe A rare sublingual cyst in an infant: oral heterotopic gastrointestinal cyst(Turkish J Pediatrics, 2014) Kinis, Vefa; Alabalik, Ulas; Aguloglu, Bulent; Ozbay, Musa; Yilmaz, Beyhan; Topcu, IsmailOral heterotopic gastrointestinal cyst is rarely seen in the oral cavity. The tongue and floor of the mouth are the most commonly affected sites. These cysts may cause feeding and respiration problems, especially in newborns and infants. A benign mass was considered according to the physical examination and ultrasonography findings. We treated the patient with simple excision. We present a three-month-old female infant who was referred to us with a cystic mass in the sublingual region.Öğe The Reconstruction of Full-thickness Ear Defects Including the Helix Using the Superior Pedicle Postauricular Chondrocutaneous Flap(Lippincott Williams & Wilkins, 2014) Selcuk, Caferi Tayyar; Durgun, Mustafa; Bozkurt, Mehmet; Kinis, Vefa; Ozbay, Musa; Bakir, SalihThe ear is a complex structure with specific anatomical landmarks and different surface contour properties. In this article, we present the results that we obtained after reconstruction of full-thickness defects of the upper and middle third of the ear including the helix using a superior auricular artery (SAA) pedicled chondrocutaneous flap. In this study, 8 patients underwent reconstructions with postauricular SAA pedicled chondrocutaneous flaps between March 2009 and May 2011. Seven patients were male (88%), and 1 patient was female (12%). The age range was between 27 and 78 years, with a mean age of 57 years. The causes of the defects were tumor excisions in 6 patients and trauma in 2 patients. No serious postoperative complications such as wound infection, wound dehiscence, or partial or total flap loss were observed in any of the patients. A good cosmetic result was obtained with this technique with maximum preservation of the anatomical landmarks and without an effect on the vertical height or projection of the ear. In our experience, the postauricular SAA pedicled chondrocutaneous flap can be used as an appropriate alternative for the treatment of full-thickness defects of the upper and middle thirds of the ear including the helix.Öğe The relationship between high incidence of deep neck infection and toothbrushing frequency(Academic Journals, 2012) Bakir, Salih; Gunay, Ahmet; Tanriverdi, Halis; Gun, Ramazan; Atilgan, Serhat; Palanci, Yilmaz; Ozbay, MusaThis study aimed to investigate and compare the frequency of toothbrushing and dental health status between deep neck space infection (DNSI) patients with dental origin and healthy population. 64 participants were included in this study in the form of two groups. The first group consisted of 34 DNSI patients with dental onset, and the second group consisted of 30 participants (control group). Study was carried out in two separate categories: the frequency of toothbrushing and assessment of dental health status. Toothbrushing frequency was evaluated with a questionnaire. Dental health status was assessed for periodontal and dental disease by periodontist according to the some widely used indicators; Decayed Missing Filled Teeth (DMFT) scores, Plaque Index score, Gingival Index score and Sulcus Bleeding Index score. Present study showed that the majority had brushed their teeth occasionally. In DNSI group, the percentage of never toothbrushing was very high and regular toothbrushing rate was so low. DNI group has higher scores than the control group and this indicates poor oral hygiene. Our results showed that, oral health was impaired and regular toothbrushing seems to have been neglected in DNSI group. In our opinion, this negligence is a very important contributory factor towards the more occurrence of deep neck abscess.Öğe The relationship between high incidence of deep neck infection and toothbrushing frequency(Academic Journals, 2012) Bakir, Salih; Gunay, Ahmet; Tanriverdi, Halis; Gun, Ramazan; Atilgan, Serhat; Palanci, Yilmaz; Ozbay, MusaThis study aimed to investigate and compare the frequency of toothbrushing and dental health status between Deep neck space infection (DNSI) patients with dental origin and healthy population. 64 participants were included in this study in the form of two groups. The first group consisted of 34 DNSI patients with dental onset, and the second group consisted of 30 participants (control group). Study was carried out in two separate categories: the frequency of toothbrushing and assessment of dental health status. Toothbrushing frequency was evaluated with a questionnaire. Dental health status was assessed for periodontal and dental disease by periodontist according to the some widely used indicators; DMFT scores, Plaque Index score, Gingival Index score and Sulcus Bleeding Index score. Present study showed that the majority had brushed their teeth occasionally. In DNSI group, the percentage of never toothbrushing was very high and regular toothbrushing rate was so low. DNI group has higher scores than the control group and this indicates poor oral hygiene. Our results showed that, oral health was impaired and regular toothbrushing seems to have been neglected in DNSI group. In our opinion, this negligence is a very important contributory factor towards the more occurrence of deep neck abscess.Öğe Seborrheic keratosis of the external auditory canal in a 1-year-old boy(Turkish J Pediatrics, 2012) Ozbay, Musa; Kinis, Vefa; Firat, Ugur; Bakir, Salih; Yorgancilar, EdizSeborrheic keratosis is a common and benign cutaneous lesion occurring on the trunk, extremities, and head and neck of the elderly. It is rarely seen in the external auditory canal. We present a case of seborrheic keratosis in the external auditory canal of a one-year-old child. The patient was treated successfully with surgical excision.
