Yazar "Ozbay, M." seçeneğine göre listele
Listeleniyor 1 - 5 / 5
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe Effects of caffeic acid phenethyl ester on cisplatin ototoxicity(Royal Belgian Soc Ear, Nose, Throat, Head & Neck Surgery, 2016) Ozbay, M.; Sengul, E.; Kinis, V.; Alabalik, U.; Yilmaz, B.; Topcu, I.Purpose: To report histological and electrophysiological data in rats treated with cisplatin and caffeic acid phenethyl ester. Methods: We randomly divided 28 Wistar rats into four groups of seven, to be treated as follows: control (saline), cisplatin, CAPE and cisplatin-CAPE. Distortion product otoacoustic emission (DPOAE) measurements were performed on day one (before drug administration) and day five under anaesthesia. All animals were killed under general anaesthesia on day five after the DPOAE measurement. The cochleae of each rat were histopathologically and immunohistochemically evaluated. Results: The outer hair cells were mostly preserved in the control and CAPE groups. Moderate -to -severe and mild -to moderate hair cell losses were detected in the cisplatin and cisplatin-CAPE groups, respectively. DPOAE assessments revealed significant deterioration in the cisplatin group (P < 0.05). The difference between the cisplatin and cisplatin-CAPE groups was statistically significant (P < 0.05). Conclusion: CAPE prevents cisplatin ototoxicityÖğe A rare mass in the neck region: Primary hydatid cyst(Galenos Yayincilik, 2012) Gul, A.; Bakir, S.; Ozbay, M.; Kinis, V.; Aguloglu, B.; Avci, Y.Hydatid disease is a common parasitic infestation caused by the parasite Echinococcus granulosus. It is a serious health problem most frequently encountered in rural areas where domestic livestock-raising is common. Humans can be infected accidentally through oral ingestion of tapeworm eggs with contaminated water, food, and green vegetables or direct contact with host. It affects both animals and humans. Complete surgical excision is the gold standard treatment for hydatid cyst. Postoperative medical treatment with antihelminthic drugs (benzimidazole derivatives) are frequently combined with surgical treatment to prevent recurrence of disease and high-risk contamination. Although hydatid cysts usually involve in liver and lungs, less frequently may occur in any area of the body. A hydatid cyst occurrence in the head and neck area is extremely rare. So this disease does not usually come to mind. Therefore in this case, we wish to draw attention to possibility of the hydatid disease in the neck. For this reason, we present an unusual case of primary hydatid cyst located in the neck region in a 42-year-old male patient, who engaged in livestock.Öğe Relationship between hearing loss and sexual dysfunction(Cambridge Univ Press, 2013) Bakir, S.; Penbegul, N.; Gun, R.; Yorgancilar, E.; Kinis, V.; Ozbay, M.; Atar, M.Objective: Deafness may be one of the factors that leads to a change in sexual function. This study aimed to assess sexual function, in particular erectile dysfunction, in male patients with hearing loss. Materials and methods: We studied two groups: (1) adult men with acquired, bilateral, sensorineural hearing loss, and (2) healthy, adult, married men demonstrated to have normal hearing levels, as the control group. Sexual function was assessed using the International Index of Erectile Functions questionnaire, and quality of life using the 36-Item Short-Form Health Survey. Results: There was a statistically significant difference between the groups regarding the International Index of Erectile Functions questionnaire results (p < 0.001), both for each of the five questionnaire domain scores and for the total score. Conclusion: Our results indicate that men with mild or moderate sensorineural hearing loss have poorer sexual health.Öğe The role of asymmetric dimethylarginine (ADMA) and leptin in hypertensive patients(Elsevier Ireland Ltd, 2007) Atamer, A.; Ilan, N.; Kocyigit, Y.; Toprak, G.; Ozbay, M.; Celik, Y.[Abstract Not Available]Öğe The role of asymmetric dimethylarginine (ADMA) and leptin in hypertensive patients(Sage Publications Ltd, 2008) Atamer, A.; Ilhan, N.; Kocylgit, Y.; Toprak, G.; Ozbay, M.; Celik, Y.We investigated the role of leptin and asymmetric dimethylarginine (ADMA) in uncomplicated hypertension. We also investigated their relationship with insulin resistance and serum levels of several metabolic parameters, including homocysteine, lipoprotein(a) and malondialdehyde (MDA). A total of 34 untreated newly-diagnosed hypertensive patients (seven men and 27 women; mean age, 57.4 +/- 10.1 years) and 38 normotensive healthy subjects (20 men and 18 women; mean age, 55.9 +/- 8.7 years) were studied prospectively. Serum leptin, homocysteine, lipoprotein(a), MDA and insulin resistance (HOMA-IR) were significantly higher in hypertensive patients compared with normotensive subjects. There were no significant differences in ADMA, insulin-like growth factor-1 and insulin-like growth factor binding protein-3 between the two groups. No correlation was found between serum ADMA and leptin levels. Our findings suggest that high serum leptin and homocysteine levels, oxidative stress and insulin resistance may be important risk factors for atherosclerosis among patients with uncomplicated hypertension.
