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    Appendicial mucoceles: Evaluation of two cases
    (2000) Uzunlar A.K.; Yaldiz M.; Saltabas F.; Ozaydin M.
    The pathology of mucocele was reviewed and two appendiceal mucoceles were evaluated. These were diagnosed at the Pathology Department of Dicle University between 1990 and 1999. The changes in the lining epithelium of the mucocele were emphasized.
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    Öğe
    Nitrendipine and stress-induced ulcers: Preliminary tudy
    (1997) Inalöz S.; Ozaydin M.; Sari I.; Cicek R.; Guney B.; Yenice N.
    Nitrendipine is a derivative of the dihydropyridine of calcium channel blockers and released for angina and hypertension. The therapeutic effect of nitrendipine was observed histologically against stress-induced gastric and duodenal ulcers in rats. Twenty-four male Wistar-albino rats were separated into three groups (n = 8), a control (non-stress) and two stress groups. The stressed group rats were exposed to starvation and cold-restraint in this study. The first stress group was given only a placebo whereas the second stress group was treated with nitrendipine. After treatment with nitrendipine, the total rea of the affected lesional mucosa was considerably reduced in both duodenal and gastric mucosa. Macroscopically, the surface area of the affected lesional mucosa was measured as 1/5 of the total duodenal mucosa. Moreover, the surface area of the affected lesional mucosa was measured as 1/8 of the total surface area in the stomach. In microscopic examination, tissue regeneration was conspicuous particularly in the gastric epithelium. A few hyperchromatic epithelial cells were noticed in some fields of the duodenal mucosa. Furthermore, tissue regeneration was not conspicuous as in the gastric mucosa. So we think that nitrendipine can be used in both gastric and duodenal stress ulcer treatment. However, in the healing process, therapeutic effect of nitrendipine was superior in stomach with conspicuous tissue regeneration.
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    Öğe
    Omeprazole, nitrendipine, famotidine and stress-induced ulcers
    (1997) Inaloz S.S.; Canberk Y.; Ozaydin M.; Sari I.; Yenilmez E.; Ulak G.; Goral V.
    Background: Omeprazole inhibits gastric acid secretion by blocking the proton pomp of the gastric parietal cell. Nitrendipine is a derivative of dihydropyridine group of calcium channel blockers and administrated for angina and hypertension. Famotidine is one of the newer histamine H2 receptor antagonists and heals gastric and duodenal ulcers by reducing gastric acid output. Objectives: The healing effects of omeprazole, nitrendipine and famotidine on stress-induced gastric ulcers were investigated in rate. Methods: Forty male Wistar-albino rats were separated into five groups (n=8), a control (non-stress) and four experimental (stress) groups. Experimental rats were treated with omeprazole, nitrendipine, famotidine or a placebo after the stresses of starvation and cold-restraint. Results: Macroscopically, the mean area of the affected lesional mucosa was 1/4 of the total gastric mucosa in the famotidine treated group and 1/5 of the total gastric mucosa in the nitrendipine treated group. A considerably decrease was observed in the omeprazole treated group in which the mean area of the lesional mucosa was only in 1/8 of the total gastric mucosa. On microscopic examination, congestive vessels and chronic inflammatory cell infiltrates were significantly reduced in the omeprazole treated group. Tissue regeneration was more prominent in the omeprazole group than me other groups. Conclusion: Omeprazole was found to be superior in terms of the effect on the healing process to nitrendipine and famotidine. Although therapeutic effects of nitrendipine and famotodine were observed, those were less than omeprazole.