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Öğe Cardiac Metastasis of a Low-Grade Myofibroblastic Sarcoma(Wiley, 2014) Oylumlu, Muhammed; Yildiz, Abdulkadir; Ercan, Suleyman; Oylumlu, Mustafa; Davutoglu, VedatWe aim to present a rare case of low-grade myofibroblastic sarcoma arising in the inguinal region accompanied by cardiac metastasis. A 36-year-old male patient suffering from recurrent inguinal swelling was operated on and the initial histopathological evaluation mistakenly diagnosed the condition as benign. During follow-up, a recurrence of mass was detected in the same region and a pathological examination revealed a low-grade myofibroblastic sarcoma. Cardiac metastasis was diagnosed shortly before rapid disease progression and death. The learning points relevant to this case are as follows: (1) Echocardiographic screening in patients with noncardiac myofibroblastic sarcomas may be helpful in the detection of silent metastasis. (2) Low-grade myofibroblastic sarcomas in the inguinal region may be misdiagnosed as benign after enucleation. Thus, rigorous histopathological examination of myofibroblastic sarcomas is crucial. (3) According to our knowledge, this is the first report of a low-grade myofibroblastic sarcoma to have a potential for cardiac metastasis with potentially fatal course. Mini-Abstract We present a case of low-grade myofibroblastic sarcoma arising from inguinal region accompanied by cardiac metastasis. A 36-year-old male patient suffering from recurrent inguinal swelling was operated. Initial evaluation mistakenly diagnosed the condition as benign. During follow-up, recurrence of mass revealed a low-grade myofibroblastic sarcoma. Echocardiographic screening in patients with noncardiac myofibroblastic sarcomas may be helpful in detecting silent metastases before development of cardiac symptoms in terms and may offer prognostic information. This is first report of a low-grade myofibroblastic sarcoma to metastasize to myocardium. Cardiac metastasis of a sarcoma might have rapid progression of the disease with fatal course.Öğe Circadian Variation of Blood Pressure Is Impaired in Normotensive Pregnant Women with Gestational Diabetes Mellitus(Taylor & Francis Inc, 2013) Soydinc, Hatice Ender; Davutoglu, Vedat; Sak, Muhammet Erdal; Ercan, Suleyman; Evsen, Mehmet Siddik; Kaya, Hasan; Oylumlu, MuhammedData about circadian blood pressure (BP) in normotensive patients with gestational diabetes mellitus (GDM) are lacking. Thus, we sought to compare dipper and nondipper circadian variation of BP profile between normotensive women complicated with GDM and normal pregnant women. Forty-two women with GDM and 33 normal uncomplicated pregnant women who met the entry criteria for the study were enrolled in the study. Twenty-four-hour noninvasive ambulatory blood pressure monitoring and echocardiography to measure the left ventricle mass index and diastolic parameters were performed. Nocturnal blood pressure dipping was calculated as follows: (awake BP - sleep BP) x 100/awake BP. Patients with a nocturnal reduction in average daytime systolic BP and diastolic BP of less than 10% were classified as nondippers. Left ventricle mass index was higher in normotensive pregnant women with GDM group than in normal pregnant subjects (101.98 +/- 24 g/m(2) vs. 90.67 +/- 15 g/m(2), P < .018). Significant nocturnal systolic and diastolic nondippings were observed in GDM groups compared with normal subjects. From diastolic variables, the mitral E velocity and isovolumetric relaxation time were compatible with diastolic dysfunction relaxation abnormalities (P = .003 and P = .015, respectively) in nondipper group. From all confounding factors, only E velocity (P = .002) and diagnosis of GDM (P < .001) were predictive of nondipper circadian variation. This study shows that (i) circadian BP is impaired in normotensive pregnant subjects with GDM, (ii) the left ventricle mass index is higher in pregnant subjects with GDM than in normal pregnant subjects who despite a 24-hour BP are within normal limits, and (iii) in nocturnal nondipper group, the tendency to having diastolic relaxation abnormalities is noted.Öğe The effect of the glucose-insulin-potassium solution on the p-wave dispersion of the heart failure patients(Aves Press Ltd, 2012) Ercan, Suleyman; Oylumlu, Muhammed; Oylumlu, Mustafa; Soydinc, Serdar; Davutoglu, VedatAtrial fibrillation (AF) has adverse effects on the disease prognosis and the functional capacity during heart failure. P wave dispersion has been considered as one of the most important parameters predicting the development of AF. It is known that glucose-insulin-potassium (GIK) infusion has favorable metabolic and hemodynamic effects. The aim of our study is to investigate the effects of GIK infusion on P wave dispersion in patients with heart failure. In our study, 30 patients with the diagnosis of heart failure and a low left ventricular ejection fraction (EF<40%) were included. Fifteen patients randomized to GIK solution (20 U insulin and 60 mEq KCl in 20% 500 ml dextrose solution) in 8 hours for consecutive 3 days (Group I) and other 15 patients were randomized to isotonic NaCl solution in addition to the conventional therapy (Group II, control). Twelve-lead electrocardiography were recorded in all patients to detect the P wave dispersion. P wave dispersion was calculated between the Group I and Group II patients before the study respectively (19.4 +/- 7.5 and 19 +/- 6.3) (p>0.05). In Group I, P wave dispersion measured after GIK infusion was 13 +/- 6.5. In group II, P wave dispersion measured after 0.9% NaCl solution infusion were 20.4 +/- 6.4. P wave dispersion was found significantly lower in patients administrated GIK infusion (p=0.001). According to the present study, we showed that the P wave dispersion which predicts AF was significantly lower in the patients treated with GIK than in the control group.Öğe Gebelik sayısı ile koroner arter hastalığı şiddeti arasındaki ilişki(2010) Davutoğlu, Vedat; Oylumlu, Muhammed; Soydinç, Serdar; Yüce, Murat; Oylumlu, Mustafa; Ercan, Süleyman; Akçay, MuratAmaç: Kadınlarda gebelik sırasında gözlenen dislipideminin uzun dönemde koroner arter hastalığı sıklığını arttırıp arttırmadığına dair literatürde farklı bilgiler bulunmaktadır. Çalışmamızda koroner arter hastalığı tanısı alan kadın hastalarda, gebelik sayısının aterosklerozun şiddetine olan etkisini Gensini skoru ile değerlendirmeyi amaçladık. Gereç ve Yöntem: Çalışmamıza koroner anjiyografisi yapılmış ve koroner arter hastalığı tanısı konulmuş hastalar arasından 200 menopoz sonrası kadın hasta dahil edilmiş ve ateroskleroz yükü Gensini skoru kullanılarak hesaplanmıştır. Hasta dosyalarından kardiyak risk faktörleri, lipid profilleri ve demografik özellikleri kaydedilmiştir. Bulgular: Gebelik sayısı ve Gensini skoru ile değerlendirilen koroner ateroskleroz yaygınlığı arasındaki ilişki incelendiğinde aralarında anlamlı bir ilişki bulunamadı (p=0,61). Benzer şekilde gebelik sayısı ve çok damar hastalığı arasında da anlamlı ilişki mevcut değildi (p=0,69). Gensini skoru ve kardiyak risk faktörleri arasındaki ilişki incelendiğinde diyabet (p=0,003) ve LDL kolestrol (p=0,03) ile anlamlı ilişki gösteriyordu. Gensini skor bağımlı değişken regresyon analizi yapıldığında yaş (p=0,001), diyabet (p=0,004), HDL kolestrol (p=0,035), LDL kolestrol (p=0,031) Gensini skor ile anlamlı ilişki göstermekte idi. Sonuç: Çalışmamızda gebelik sayısının, koroner arter hastalığının şiddeti ve yaygınlığı üzerine etkisini araştırdık. Çalışma sonucunda gebelik sayısı ile ateroskleroz şiddeti arasında anlamlı bir ilişki bulamadık. Gebelik sayısının aterokleroz şiddeti ile ilişkili olmaması gebelik seyri boyunca izlenilen bazı antiaterojenik değişikliklerin dengeleyici etkisine bağlanabilir. Bu konu çok hasta sayılı prospektif çalışmalarla irdelenmelidir.Öğe İmplante edilen kardiyoverter defi brilatörlerin uygunsuz şokunun nadir bir nedeni: Tremor(Kartal Koşuyolu Yüksek İhtisas Eğitim ve Araştırma Hastanesi, 2013) Oylumlu, Mustafa; Oylumlu, Muhammed; Ertaş, Faruk; Kaya, Hasan; Bilik, Mehmet Zihni; Soydinç, Serdarİmplante edilen kardiyoverter defi brilatörler primer ve sekonder korumada ani ölümü önlemek amacıyla yaygın olarak kullanılmaktadır. Bu cihazlar gerektiği zaman doğru akım şoku uygulayarak ventriküler taşikardi ve ventriküler fi brilasyon ataklarını sonlandırmaktadır. Ancak bu yararlı etkilerine rağmen uygunsuz şok implante edilen kardiyoverter defi brilatörlerin önemli bir yan etkisi olarak kalmaya devam etmektedir. Uygunsuz implante edilen kardiyoverter defi brilatör şokları hastalarda ağrı ve psikolojik yan etkilere neden olarak yaşam kalitesini bozmakta, hatta yeni aritmi gelişimini indükleyebilmektedir. Bu yazıda tremorun neden olduğu uygunsuz implante edilen kardiyoverter defi brilatör şoku alan bir olgu sunulmaktadır.Öğe Kalp yetersizliği hastalarında glukoz-insülin-potasyum infüzyonunun p dalga dispersiyonu üzerine etkisi(2012) Soydinç, Serdar; Oylumlu, Mustafa; Davutoğlu, Vedat; Oylumlu, Muhammed; Ercan, SüleymanKalp yetersizliği seyrinde izlenilen atriyal fibrilasyon (AF) prognoz ve fonksiyonel kapasite üzerinde olumsuz etkilere neden olmaktadır. P dalga dispersiyonu AF gelişimini predikte eden önemli parametrelerden biri olarak kabul görmüştür. Glukoz-insülinpotasyum (GİK) infüzyonunun hemodinamik ve metabolik olumlu etkileri bilinmektedir. Çalışmamızda kalp yetersizliği olan hastalarda GİK infüzyonunun P dalga dispersiyonu üzerine olan etkisi araştırıldı. Çalışmamıza kalp yetersizliği ve düşük sol ventrikül ejeksiyon fraksiyonu (EF<%40) ile yatırılan 30 hasta dahil edildi. Hastalardan rastgele seçilen on beşine (Grup I) 3 gün süreyle her gün 8 saatlik infüzyon şeklinde GİK solüsyonu (%20'luk 500 ml glukoz içinde 20 Ü insülin, 60 mEq KCl) verildi. Kontrol grubu (Grup II) olarak alınan diğer on beş hastaya konvansiyonel tedaviye ek olarak yine aynı süre ve dozda %0.9'luk NaCl infüzyonu uygulandı. Hastaların tümünden çalışma başlangıcı ve sonunda P dalga dispersiyonu için 12 derivasyonlu elektrokardiyografi kaydı alındı. Grup I hastalar ile Grup II hastalar arasındaki P dalga dispersiyonu çalışma öncesinde sırasıyla (19.4±7.5 ve 19±6.3) (p>0.05) hesaplandı. Grup Ide GİK infüzyonu sonrasında ölçülen P dalga dispersiyonu 13±6.5 hesaplandı. Grup IIde ise verilen %0.9 NaCl solüsyonu sonrasında P dalga dispersiyonu 20.4±6.4 olarak hesaplandı. Her iki grubun çalışma sonrası hesaplanan P dalga dispersiyonunda önemli istatistiksel fark bulundu (p=0.001) ve GİK alan grupta P dalga dispersiyonu önemli ölçüde kısalmaktaydı. Çalışmamıza göre GİK infüzyonu alan hastalarda AFnin prediktör olan P dalga dispersiyonunun kontrol grubuna göre anlamlı olarak azaldığı gösterildi.Öğe Mitral balon valvüloplastiye bağlı ciddi mitral perforasyon ve ileri mitral yetmezlik gelişen hastanın geç dönem takip ve gebelik sonucu(2012) Soydinç, Hatice Ender; Ercan, Süleyman; Davutoğlu, Vedat; Oylumlu, Muhammed; Büyükaslan, HasanCiddi mitral yetmezlik (MY), mitral balon valvüloplastinin (MBV) önemli komplikasyonlarındandır. Özellikle kapak perforasyonu sonu- cu gelişen MY’de prognozun daha kötü olduğu sanılmakla beraber paylaştığımız vakada ciddi mitral yaprakçık perforasyonu sonucu gelişen ileri MY’ye rağmen klinik ve ekokardiyografik olarak stabil seyreden hastayı ve bu hastadaki olumlu prognozun olası nedenlerini tartışmayı amaçladık. Bununla beraber hastadaki başarılı bir gebelik sürecini de bildirerek konservatif takibin bu tür hastalarda belirli durumlar gözetilerek önemli bir seçenek olabileceğini düşünmekteyiz. Valvüloplasti sonrası gelişen mitral kapak perforasyonuna bağlı ileri MY hastalarında, kimlere nasıl yaklaşılması gerektiği ile ilgili takip şeması sunmayı ve ona göre konservatif veya cerrahi seçeneklerin değerlendirilmesini amaçladık.Öğe Monocyte to high-density lipoprotein cholesterol and lymphocyte to monocyte ratios are predictors of in-hospital and long-term mortality in patients with acute coronary syndrome(Wiley, 2021) Oylumlu, Muhammed; Oylumlu, Mustafa; Arik, Baran; Demir, Muhammed; Ozbek, Mehmet; Arslan, Bayram; Acun, BarisObjective We aimed to determine the relationship between LMR and MHR and in-hospital and long-term mortality in patients with ACS. Methods We retrospectively collected patients with ACS undergoing coronary angiography between January 2012 and December 2013. Results In total, 825 patients with a mean age of 62.4 +/- 12.9 years (71.3% male) were enrolled in the study. Patients were divided into three tertiles based on MHR levels and LMR levels. In-hospital mortality of the patients was significantly higher amongst patients in the upper MHR tertile when compared with the lower and middle MHR tertile groups [30 (10.9%) vs 8 (2.9%) and 14 (5.1%); P < .001, P = .009, respectively]. Five-year mortality of the patients was significantly higher amongst patients in the upper MHR tertile when compared with the lower and middle MHR tertile groups [84 (30.5%) vs 48 (17.5%) and 57 (20.7%); P < .001, P = .005, respectively]. In-hospital mortality of the patients was significantly higher amongst patients in the lower LMR tertile when compared with the upper and middle LMR tertile groups [25 (9.1%) vs 10 (3.6%) and 17 (6.2%); P = .007, P = .130, respectively]. Five -year mortality of the patients was significantly higher amongst patients in the lower LMR tertile when compared with the upper and middle LMR tertile groups [77 (28.0%) vs 47 (17.1%) and 65 (23.6%); P = .001, P = .142, respectively]. Conclusion We have shown that high MHR and low LMR were significant and independent predictors of in-hospital and long-term mortality in patients with ACS.Öğe New inflammatory markers in pre-eclampsia: echocardiographic epicardial fat thickness and neutrophil to lymphocyte ratio(Taylor & Francis Inc, 2014) Oylumlu, Mustafa; Ozler, Ali; Yildiz, Abdulkadir; Oylumlu, Muhammed; Acet, Halit; Polat, Nihat; Soydinc, Hatice EnderBackground: Increased epicardial fat thickness (EFT) has been proposed as a new cardiometabolic risk factor. The neutrophil/lymphocyte ratio (NLR) has predictive and prognostic value in several cardiovascular diseases. The aim of this study was to explore the association between EFT and NLR in patients with pre-eclampsia. Methods: Hundred and eight pregnant patients with a mean age of 30.6 +/- 6.3 years were included in the study. Patients were divided into two groups based on the presence of pre-eclampsia. All participants underwent transthoracic echocardiography imaging, and complete blood counts were measured by an automated hematology analyzer. Statistical analysis was performed using the Chi-square, Mann-Whitney U, correlation and logistic regression tests, and receiver operating characteristic (ROC) analysis. Result: The mean EFT value of the pre-eclampsia group was significantly higher than the control group (6.9 +/- 0.6 versus 5.6 +/- 0.6; p < 0.001), and the NLR value of the pre-eclampsia group was also significantly higher than the control group (7.3 +/- 3.5 versus 3.1 +/- 1.1; p < 0.001). Multivariate analysis showed that increased levels of NLR and echocardiographic EFT are independent predictors of pre-eclampsia. In the receiver operating characteristic analysis, a level of EFT >= 6.2 mm and NLR >= 4.1 predicted the presence of pre-eclampsia with 77.8% sensitivity, 79.6% specificity and 83.3% sensitivity, 81.5% specificity, respectively. Conclusion: Unlike many other inflammatory markers and bioassays, NLR and echocardiographic EFT are inexpensive and readily available biomarkers that may be useful for risk stratification in patients with pre-eclampsia.Öğe Novel predictor of pulmonary arterial hypertension: Monocyte to HDL cholesterol ratio(Lippincott Williams & Wilkins, 2022) Bilik, Mehmet Zihni; Oylumlu, Muhammed; Oylumlu, Mustafa; Acun, Baris; Arik, Baran; Arslan, Bayram; Acet, HalitMonocyte to HDL cholesterol ratio (MHR), lymphocyte to monocyte ratio (LMR), and neutrophil to lymphocyte ratio (NLR) have been proposed as novel systemic inflammatory markers. The aim of this study was to explore the association between MHR, LMR and NLR with pulmonary arterial hypertension (PAH). The study is a single-center, retrospective Cross-sectional study. The study group consisted of 73 patients with PAH and the control group 77 participants without cardiac pathology as determined by echocardiography. On admission, blood sampling to calculate MHR, LMR, NLR, and detailed clinical data were obtained. According to the Pearson test, systolic pulmonary artery pressure (PAP) value Higher MHR, NLR and lower LMR that indicates an enhanced inflammation were significantly increased in patients with PAH when compared with controls. Compared to many other inflammatory markers, these markers are widely available. positively correlated with the MHR and NLR (r:.35, P < .001 and r:.33, P < .001, respectively), but negatively correlated with LMR (r: -.26, P = .001). After multivariate logistic regression analysis, MHR, LMR, and NLR remained as significant predictors of PAH (OR: 2.651, 95% CI: 1.227-5.755, P = .007; OR: 0.647, 95% CI:0.450-0.931, P = .005; OR: 1.350, 95% CI: 1.054-1.650 P = .030, respectively).Öğe Platelet-to-lymphocyte ratio is a predictor of in-hospital mortality patients with acute coronary syndrome(Turkish Soc Cardiology, 2015) Oylumlu, Mustafa; Yildiz, Abdulkadir; Oylumlu, Muhammed; Yuksel, Murat; Polat, Nihat; Bilik, Mehmet Zihni; Akyuz, AbdurrahmanObjective: Platelets and inflammatory cells are vital elements of acute coronary syndromes (ACS). Recent studies have shown that the platelet-to-lymphocyte ratio (PLR) is associated with several malignancies; however, there are not enough data in cardiovascular diseases. Therefore, the aim of this study was to explore the association between PLR and in-hospital mortality in patients with ACS. Methods: We retrospectively collected patients with ACS undergoing coronary angiography. Total and differential leukocyte counts were measured by an automated hematology analyzer. Results: This study is single-centered and observational. In total, 587 patients with a mean age of 61.8 +/- 13.1 years (68.4% male) were enrolled in the study. Patients were divided into 3 tertiles based on PLR levels. In-hospital mortality was significantly higher among patients in the upper PLR tertile when compared with the middle and lower PLR tertile groups [29 (14.8%) vs. 17 (8.7%) and 2 (1.0%); p<0.001]. In the multiple logistic regression analysis, a high level of PLR was an independent predictor of in-hospital mortality, together with age, total leukocyte count, and creatinine. Using a cutoff point of 142, the PLR predicted in-hospital mortality with a sensitivity of 69% and specificity of 63%. Conclusion: Different from other inflammatory markers and assays, PLR is an inexpensive and readily available biomarker that may be useful for cardiac risk stratification in patients with ACS.Öğe Platelet-to-lymphocyte ratio is a predictor of long-term mortality in patients with acute coronary syndrome(Termedia Publishing House Ltd., 2020) Oylumlu, Mustafa; Oylumlu, Muhammed; Arslan, Bayram; Polat, Nihat; Özbek, Mehmet Nuri; Demir, Muhammed; Yıldız, Abdulkadir; Toprak, NizamettinIntroduction: Atherosclerosis is a chronic inflammatory process and inflammation is an important component of acute coronary syndrome (ACS). Platelet-to-lymphocyte ratio (PLR) is a useful parameter showing the degree of the inflammatory response. Aim: To explore the association between PLR and long-term mortality in patients with ACS. Material and methods: A total of 538 patients who had a diagnosis of ACS between January 2012 and August 2013 were followed up to 60 months. On admission, blood sampling to calculate PLR and detailed clinical data were obtained. Results: In total, 538 patients with a mean age of 61.5 ±13.1 years (69% male) were enrolled in the study. Median follow-up was 79 months (IQR: 74–83 months). Patients were divided into 3 tertiles based on PLR levels. Five-year mortality of the patients was significantly higher among patients in the upper PLR tertile when compared with the lower and middle PLR tertile groups (55 (30.7%) vs. 27 (15.0%) and 34 (19.0%); p < 0.001, p = 0.010 respectively). In the Cox regression analysis, a high level of PLR was an independent predictor of 5-year mortality (OR = 1.005, 95% CI: 1.001–1.008, p = 0.004). Kaplan-Meier analysis according to the long-term mortality-free survival revealed the higher occurrence of mortality in the third PLR tertile group compared to the first (p < 0.001) and second tertiles (p = 0.009). Conclusions: PLR, which is an easily calculated and universally available marker, may be useful in long-term risk classification of patients presenting with ACS.Öğe Prognostic value of nutritional and inflammatory scores in Transcatheter aortic valve replacement patients(Dicle Üniversitesi Tıp Fakültesi, 2022) Özbek, Mehmet; Acun, Barış; Arık, Baran; Demir, Muhammed; Oylumlu, Muhammed; Toprak, NizamettinBackground: Aortic Stenosis (AS) is a common heart valve disease that especially affects the elderly population and is seen with the aging of the society. In recent years Transcatheter aortic valve replacement patients (TAVR) has been increasingly applied worldwide as a procedure for the treatment of severe AS. Recently, various biomarkers and derived marker approaches have been studied in AS patient groups as in many cardiovascular diseases. Since it has been previously shown that increased inflammatory scores and poor nutritional scores are closely associated with the development process and prognosis of cardiovascular diseases, we hypothesized that these scores may be associated with prognosis after TAVR. Therefore, in this study, we aimed to make a detailed evaluation in terms of mortality determinants after TAVR. Methods and Results: 118 TAVR patients were included in the analysis. Median follow-up of 118 patients was 40.5 months. In terms of inflammatory status scores, the systemic immune inflammatory (SII) score (p= 0.027), the neutrophil/lymphocyte ratio (NLR) score (p= 0.012), and the platelet/lymphocyte ratio (PLR) score (p= 0.012) in the death group was found to be significantly higher. As nutritional status scores, the prognostic nutritional index (PNI) score (p= 0.003) was lower in the death group and the median Controlling Nutritional Status (CONUT) score (p= 0.002)) found significantly higher. Conclusion: In severe and high-risk AS patients undergoing TAVR, measurement of malnutrition with the CONUT score and increased inflammatory status with the SII score was associated with an increased risk of all causes mortality in longterm follow-up. It has been determined that the development of complications related to the procedure is an indicator of increased mortality not only in the short term but also in the long-term follow-up.Öğe Pulmonary Balloon Valvuloplasty during Pregnancy(Hindawi Ltd, 2012) Oylumlu, Mustafa; Aykent, Kazim; Soydinc, Hatice Ender; Oylumlu, Muhammed; Ertas, Faruk; Ozer, Hasan Orhan; Sari, IbrahimWomen with valvular heart disease have an increased risk of adverse outcomes in pregnancy; however, with appropriate evaluation and treatment, most women can successfully bear healthy children. During pregnancy, pulmonary stenosis is generally well tolerated in the absence of other haemodynamically significant lesions. We present a case of amultiparous woman, who is pregnant with her sixth child, with a severe pulmonary stenosis. She presented with exertional chest pain and dyspnea. She was managed successfully with balloon valvuloplasty.Öğe Relationship between platelet-to-lymphocyte ratio and coronary slow flow(Turkish Soc Cardiology, 2015) Oylumlu, Muhammed; Dogan, Adnan; Oylumlu, Mustafa; Yildiz, Abdulkadir; Yuksel, Murat; Kayan, Fethullah; Kilit, CelalObjective: The coronary slow flow phenomenon (CSFP), which is characterized by delayed distal vessel opacification in the absence of significant epicardial coronary disease, is an angiographic finding. The aim of this study is to investigate the association between platelet-to-lymphocyte ratio (PLR) and coronary blood flow rate. Methods: This is a retrospective observational study. It was based on two medical centers. A total of 197 patients undergoing coronary angiography were included in the study, 95 of whom were patients with coronary slow flow without stenosis in coronary angiography and 102 of whom had normal coronary arteries and normal flow. Results: The PLR was higher in the coronary slow flow group compared with the control groups (p= 0.001). In the correlation analysis, PLR showed a significant correlation with left anterior descending (LAD) artery thrombolysis in myocardial infarction (TIMI) frame count. After multiple logistic regression, high levels of PLR were independently associated with coronary slow flow, together with hemoglobin. Conclusion: PLR was higher in patients with CSFP, and we also showed that PLR was significantly and independently associated with CSFP.Öğe A simple method for the assessment of arterial stiffness in pre-eclamptic patients(Taylor & Francis Inc, 2014) Oylumlu, Mustafa; Oylumlu, Muhammed; Yuksel, Murat; Yildiz, Abdulkadir; Bilik, Mehmet Zihni; Akil, Mehmet Ata; Ozler, AliBackground: Arterial stiffness (AS), the term describes the rigidity of arterial walls, and its hemodynamic results have been shown to be associated with increase in future cardiovascular events. Women with pre-eclampsia in their past pregnancies have a higher risk of developing cardiovascular disease later in life. The goal of this study was to assess AS using a non-invasive and simple oscillometric method in pregnant women with and without pre-eclampsia. Methods: Ninety pregnant women, forty-five of which had pre-eclampsia, were included in the study. The vascular measurements were performed with a Mobil-O-Graph 24 h PWA Monitor, an automatic oscillometric device. Statistical analysis was performed using the Chi-square, independent sample t-test or the Mann-Whitney U test, Pearson correlation, and linear regression tests. Results: All the vascular function parameters were significantly higher in the patients with pre-eclampsia. The pulse wave velocity (PWV) values found in the pre-eclampsia group were positively correlated with gestational age, maternal age, glucose level, creatinine level, augmentation index, and central blood pressure. Using linear regression analysis, the PWV values were confirmed to be positively correlated with gestational age, maternal age, and central systolic blood pressure. The women with severe pre-eclampsia had significantly higher blood pressures, PWV values, augmentation indices, and cardiac outputs when compared with the patients with mild pre-eclampsia. Conclusion: Oscillometric PWV measurement is already accepted as the most reproducible quick, simple, and inexpensive non-invasive method for the assessment of large artery stiffness. It can be applied to evaluate the AS and also aid in detecting future cardiovascular risk of patients with pre-eclampsia.Öğe The usefulness of plateletcrit to predict cardiac syndrome X in patients with normal coronary angiogram(Termedia Publishing House Ltd, 2015) Oylumlu, Muhammed; Oylumlu, Mustafa; Yuksel, Murat; Dogan, Adnan; Cakici, Musa; Ozgeyik, Mehmet; Yildiz, AbdulkadirIntroduction: Cardiac syndrome X (CSX) is a clinical entity defined as the triad of typical angina pectoris on exercise, electro-cardiographic or metabolic findings of ischemia and normal epicardial coronary arteries. Platelets, whose amount in the blood is indicated with plateletcrit (PCT), play an important role in inflammatory and thrombotic processes and the physiopathology of cardiovascular events. Aim: To investigate the association between cardiac syndrome X and PCT and platelet count. Material and methods: A total of 113 patients with normal coronary angiogram were included in the study. Fifty patients with typical chest pain and evidence of myocardial ischemia in non-invasive tests formed the CSX patient group. The control group consisted of 63 age- and gender-matched patients with normal coronary arteries but without angina. Results: The mean PCT value of the CSX group was significantly higher than that of the control group (0.22 +/- 0.06 vs. 0.19 +/- 0.04; respectively, p = 0.03). Higher PCT was found to be associated with the presence of CSX in patients with normal coronary arteries by multivariate logistic regression analysis. Conclusions: We suggest that high PCT may predict the presence of cardiac syndrome X in patients with normal coronary arteries. The value of PCT appears additive to conventional expensive methods commonly used in CSX prediction.
