Yazar "Oto, Ferhat" seçeneğine göre listele

Listeleniyor 1 - 2 / 2
  • [ X ]
    Öğe
    Evaluation of volume overload by bioelectrical impedance analysis, NT-proBNP and inferior vena cava diameter in patients with stage 3&4 and 5 chronic kidney disease
    (Taylor & Francis Ltd, 2014) Yilmaz, Zulfukar; Yildirim, Yasar; Oto, Ferhat; Aydin, Fatma Yilmaz; Aydin, Emre; Kadiroglu, Ali Kemal; Yilmaz, Mehmet Emin
    Background: Determination of fluid overload is important in chronic kidney disease. Early diagnosis and treatment of volume overload may decrease morbidity and mortality. We aimed to determine body composition by using bioelectrical impedance analysis, and studying other clinical characteristics, inferior vena cava diameter, and N-terminal pro-B natriuretic peptide associated with hydration status in chronic kidney disease Stages 3&4 and 5 in patients not undergoing dialysis. Method: We examined 62 patients with Stages 3&4 and 68 patients with Stage 5 chronic kidney disease. Plasma NT-proBNP was measured and analyzed after log transformation. Inferior vena cave diameter was measured with echocardiography and indexed for body surface area. Hydration status was assessed using multi-frequency bioelectrical impedance analysis. Overhydration was defined as overhydration/extracellular water >0.15. Results: Overhydration was more frequent in Stage 5 than in Stages 3&4 patients. Systolic and diastolic blood pressure, inferior vena cava index, and log NT-proBNP were higher in overhydrated compared to non-overhydrated patients. A significant positive correlation existed between overhydration/extracellular water and log NT-proBNP, systolic and diastolic blood pressures, and inferior vena cava index. In multiple linear regression analysis, the variables associated with hydration status were male sex, extracellular water/total body water, and extracellular water/intracellular water (greater overhydration), while serum albumin levels had a negative association with overhydration. Conclusion: Overhydration is more prevalent in Stage 5 chronic kidney disease patients than in Stages 3&4 patients. Bioelectrical impedance analysis, inferior vena cava diameter, and NT-proBNP analysis in chronic kidney disease are useful methods to determine the volume overload.
  • [ X ]
    Öğe
    PREVALENCE OF FACTOR XIII VAL34LEU POLYMORPHISM IN THROMBOSIS CASES IN THE SOUTHEAST OF TURKEY AND ITS CORRELATION WITH THROMBOSIS
    (Carbone Editore, 2017) Yildirim, Mehmet Serdar; Dal, Mehmet Sinan; Karakus, Abdullah; Oto, Ferhat; Goruk, Mucahit; Akdogan, Mehmet Recai; Nas, Necib
    Background: Thrombosis is triggered by a shift in the balance of procoagulant and anticoagulant factors due to acquired or inherited causes. Factor XIII plays an important role in the stabilization of the linkage between fibrins. Three different genetic structure of Valine34Leucine polymorphism in FXIIIA have been described. Valine/Valine structure has been identified as the homozygous normal (wild-type), whereas Valine/Leucine and Leucine/Leucine structures have been identified as heterozygous and homozygous mutants respectively. Genetic polymorphisms in FXIII-A subunit vary substantially from society to society. The primary objective of this study was to determine the relationship between factor XIII polymorphisms and arterial/venous thromboembolism in the southeast of Turkey. Methods: A total of 127 patients with arterial and venous thrombosis were included as the study group and 102 healthy subjects with no thromboembolic disorders were included as the control group. Val34Leu polymorphism in FXIII was investigated in both groups using PCR (Polymerase chain reaction). Results: The prevalence of the polymorphism in the study and control groups were compared with chi-square test, no statistically significant differences were found (the prevalence in the study and control group are 68.5% and 66.7% for V/V allele, 29.2% and 29.4% for V/L allele, and 2.4% and 3.9% in L/L allele respectively, with p = 0.787). When deep vein thrombosis (DVT) diagnosed female patients group (n = 8) was compared to the healthy female control group, V/L allele was significantly lower, whereas L/L allele was significantly higher (p = < 0.01). Conclusions: This study indicates that there is no evidence for association between factor XIII-A Val34Leu polymorphism and arterial/venous thromboembolism. The significant result we found for the DVT patients should be strengthened by further studies with greater number of cases. In future, further studies are needed with more specific groups and with greater numbers of patients.