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    Comparison of the efficacy of letrozole and gonadotropin combination versus gonadotropin alone in intrauterine insemination cycles in patients with unexplained infertility
    (Yuzuncu Yil Universitesi Tip Fakultesi, 2020) Oğlak S.C.; Sakar M.N.; Ege S.; Otçu S.M.Ö.; Obut M.; Kahveci B.; Yıldız İ.
    This study aimed to determine the outcomes of combined treatment of letrozole (LTZ) with recombinant follicle-stimulating hormone (rFSH) in comparison with rFSH alone in intrauterine insemination (IUI) cycles. This study consisted of 86 patients who experienced 106 IUI cycles. Patients were classified into two treatment groups: group I underwent a combination of LTZ plus rFSH, and group II received rFSH alone. Ovulation was tr iggered with human chorionic gonadotropin (hCG), and IUI performed 36 hours later. The number of follicles ?18 mm, endometrial thickness, required dose of FSH, duration of ovulation induction (OI), clinical pregnancy rates, multiple pregnancy rates, spontaneous abortion rates, and live birth rates were evaluated. The total required rFSH dose during the OI was significantly lower in the LTZ-rFSH combination group than the rFSH alone group (401.2±177.1 IU and 770.1±345.8 IU, respectively, p<0.001). The days of stimulation with rFSH were also lower in the LTZ co-treatment group than the rFSH-alone group (5.2±1.3 days and 10.1±3.0 days, respectively, p<0.001). Clinical pregnancy rate was 17.0% in LTZ-rFSH group, and 15.2% in rFSH group (p>0.05). The combined use of LTZ with rFSH resulted in a lower required dose of rFSH, a similar and ac ceptable endometrial thickness at the day of hCG administration, and comparable pregnancy rate compared with rFSH alone. © 2020, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.