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FOUR-YEAR STUDY OF ENTECAVIR EFFICACY AND SAFETY IN NUCLEOS(T)IDE-NAIVE HBeAg POSITIVE CHRONIC HEPATITIS B PATIENTS
(Sestre Milosrdnice Univ Hospital, 2014) Celen, Mustafa Kemal; Dal, Tuba; Ayaz, Celal; Bayan, Kadim; Mert, Duygu; Deveci, Ozcan; Oruc, Ebru Kursun
Entecavir is a guanosine analogue with activity against hepatitis B virus. The aim of this 4-year trial was to evaluate entecavir treatment in nucleos(t)ide-naive HBeAg-positive chronic hepatitis B patients. Forty-nine patients received entecavir and nine of them withdrew from the trial at the end of week 96. The initial mean value of alanine aminotransferase was 79.4 +/- 41.5 IU/L, and at the end of the 4-year study period, 90% of patients had alanine aminotransferase values within the normal range. At week 96, 91.7% of patients had HBV DNA <300 copies; at month 48, 90% of patients had HBV DNA <50 IU/mL. HBeAg loss was recorded in 7.1% of patients at week 96 and in 12.5% at month 48. The rate of HBeAg seroconversion was 4.8% at week 96 and 7.5% at month 48. The rate of HBsAg seroconversion was 2.1% at week 96 and 2.5% at month 48. Entecavir as a potent and safe agent leading to continuous viral suppression proved to be safe and well tolerated therapy.