Yazar "Oguz A." seçeneğine göre listele
Listeleniyor 1 - 4 / 4
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe Anesthetic management of pregnant patients with Appendectomy(2013) Celik F.; Oguz A.; Yildirim Z.B.; Guze A.; Dogan E.; Ciftci T.; Aycan I.A.Our goal was to present our anesthesia procedure of pre-diagnosis and laparotomy on pregnant patients with acute appendicitis. After approval Ethics Committee, 77 pregnant patients with a diagnosis of acute appendicitis were evaluated. Patients were separated into two groups: group G (general anesthesia) and Group S (spinal anesthesia), according to the method of anesthesia applied. The patients' age, gestational age, method of anesthesia applied, duration of hospital stay, duration of anesthesia, number of pregnancies, leukocyte count and complications suffered were compared between the groups. After the surgery, with regular and adequate spontaneous respiration, protective airway reflexes present, and with vital parameters normal and within clinical limits, the patients were sent for internal evaluations. The demographic information of the cases is shown in table 1. In comparing the groups, the hospital stay duration of group S was significantly short. Looking at the incisions made for the surgical procedures, in group S relative to the pararectal incision average, the McBurney incision average was greater. In group G, the number of perforated appendicitis cases was higher. The anesthesia duration was short to a significant degree in group S. In order to protect the mother and baby from the negative effects of general anesthesia, as well as to lower costs by decreasing the duration of stay in the hospital, the spinal anesthesia technique could be a preferable procedure for selected pregnant acute appendicitis patients. G: general anesthesia, S: spinal anesthesia.Öğe Protective effect of sildenafil on the heart in hepatic ischemia/reperfusion injury(Science Printers and Publishers Inc., 2021) Ekinci A.; Oguz A.; Aşır F.; Ekinci C.; Dursun R.OBJECTIVE: To investigate the effect of sildenafil on reducing the impact of hepatic ischemia/reperfusion (HIR) injury established by Pringle maneuver on the heart of rats. STUDY DESIGN: Forty Wistar albino rats were divided into 4 groups: Sham (laparotomy only), Control (laparotomy following sildenafil application), IR (ischemia/reperfusion injured by HIR), and IR+SIL (injured by HIR following sildenafil application). Ischemia was developed by clamping the hepatoduodenal ligament for 30 minutes; then reperfusion was applied for 30 minutes. Sildenafil (single dose of 50 mg/kg) was administered by oral gavage for 15 minutes before ischemia. Blood samples of rats were collected from Sham and Control groups at 60 minutes and from IR and IR+SIL groups at 30 minutes after initiation of reperfusion for biochemical analysis. Meanwhile, heart tissues were sampled for biochemical analysis. Malondialdehyde (MDA) and total antioxidant capacity (TAC) in serum samples and TAC, total oxidative capacity (TOC), and oxidative stress index in heart tissues were examined biochemically. RESULTS: Serum MDA levels were elevated significantly in the IR and IR+SIL groups as compared to the sham group. Sildenafil treatment inhibited MDA increase considerably in the IR+SIL group as compared to the IR group. Serum TAC levels were elevated significantly in the sildenafil and control groups (compared with sham groups) and in the IR+SIL group (compared with the IR group). TAC levels detected in heart tissue increased significantly in the IR group as compared to the sham group; however, sildenafil treatment had no effect on this increase. CONCLUSION: Heart tissue was affected by HIR. It was revealed that sildenafil treatment may prevent the oxidative stress via increasing serum TAC levels in both control and IR+SIL groups. © Science Printers and Publishers, Inc.Öğe Rectovaginal fistulas: Five year's experience(Societa Editrice Universo, 2014) Taskesen F.; Arikanoglu Z.; Bostanci S.; Oguz A.; Uslukaya O.; Turkoglu A.; Veli Ulger B.Background: Rectovaginal fistula is an epithelial connection between the anterior wall of the rectum and posterior wall of the vagina. The etiology of the rectovaginal fistula can be trauma orginated from violent acts or foreign bodies as well as trauma during obstetric, gynecologic, or colorectal surgeries. The purpose of this study was to share our clinic experience and surgical management for rectovaginal fistulas. Patients and Methods: This study was conducted at the Department of General Surgery, University of Dicle. All patients who were treated for rectovaginal fistulas between January 2005 and December 2011 were included to this study. Results: There were fifteen patients in a mean age of 32 ± 9.6. The most common complains of patients were arrival of gas and stool from the vagina. The etilogy of rectovaginal fistula was most commonly obstetric trauma in our patients and three of them had anal incontinance. The mean time of hospital stay was 5 days± 1.7. Postoperative wound infection was seen in two patients and reccurence disease occurred in two patients during the postoperative period. Conclusions: Rectovaginal fistula treatment is a challenging condition for the surgeon since anatomical relationships and different surgical conditions changes according to the paitents. Various surgical techniques are available for the management of rectovaginal fistulas according to their etiology, size, location. For the treatment of low fistulas, best results were achieved using conservative fistulectomy, layer closure, and both-sided covering of the tissue defect with advancement vaginal and rectal flaps. © Società Editrice Universo (SEU).Öğe Trastuzumab-based retreatment after lapatinib in heavily pretreated HER2 positive metastatic breast cancer: An anatolian society of medical oncology study(Asian Pacific Organization for Cancer Prevention, 2015) Uncu D.; Bayoglu I.V.; Arslan U.Y.; Kucukoner M.; Artac M.; Koca D.; Oguz A.Background: For HER2 positive metastatic breast cancer (MBC), continuing anti-HER2 therapy beyond progression is associated with improved outcome. However retreatment with trastuzumab after lapatinib progression is controversial. We retrospectively analyzed the efficacy of trastuzumab-based chemotherapy in HER2+ metastatic breast cancer patients whose disease progressed after lapatinib. Materials and Methods: Between October 2010 and May 2013, 54 patients whose disease progressed after lapatinib were retreated with trastuzumab-based chemotherapy. Efficacy and toxicity results were evaluated retrospectively. Results: The median age of patients was 46 (range 27-67). Fourteen patients (26%) had metastases at the time of diagnosis. All of the patients had received trastuzumab in an adjuvant or metastatic setting, while 16 (30%) had received two lines of trastuzumab. All patients had received lapatinib plus capecitabine. The median chemotherapy line for the metastatic setting was 2 (range 1-7). Cranial metastases were identified in 27 (50%) patients. 53 patients received trastuzumab-based chemotherapy following lapatinib progression while one patient received trastuzumab monotherapy. Combination chemotherapy consisted of navelbin (n=33), taxane (n=10), gemcitabine (n=2), platinum (n=2) and platinum with taxane (n=6). The median treatment cycle was 5 (range 1-44). Among 49 patients assessed for response 2 (4%) showed CR, 12 (25%) PR, 11 (22%) SD and 24 (49%) disease progression. Asymptomatic cardiotoxicity was reported in 2 (4%) of the patients. At a median follow-up of 9 months (1-39), median progression-free survival was 5 months (95% CI 4.1-5.9) and median overall survival was 10 months (95% CI 6.9-13.0). PFS and OS were not affected by the absence/presence of cranial metastases. Conclusions: Retreatment with trastuzumab-based therapy after lapatinib progression showed efficacy in heavily treated MBC patients.
