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    Assessment of Right Ventricular Myocardial Performance Index In Patients Who Underwent Percutaneous ASD Closure Devices
    (Excerpta Medica Inc-Elsevier Science Inc, 2017) Ozturk, Onder; Ozturk, Unal; Nergiz, Sebnem; Ozturk, Sengul; Karahan, Zulkif
    [Abstract Not Available]
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    The Association Between Neutrophil/Lymphocyte Ratio and Cardiac Pacemaker Infection
    (Wiley, 2023) Ozturk, Cansu; Nergiz, Sebnem; Ozturk-, Onder
    [Abstract Not Available]
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    Fusidic Acid Resistance in Staphylococcus aureus Strains in an Interval of Ten Years (2001-2011)
    (Ortadogu Ad Pres & Publ Co, 2012) Nergiz, Sebnem; Atmaca, Selahattin; Ozekinci, Tuncer; Tekin, Alicem
    Objective: Fusidic acid is a steroid-like antibiotic which is used alone or consecutively in combination with other antimicrobial drugs in the treatment of staphylococcal infections, including the strains resistant to methicillin. In this study, we aimed to compare fusidic acid resistance rates in Staphylococcus aureus [methicillin susceptible Staphylococcus aureus (MSSA) and methicillin resistant Staphylococcus aureus (MRSA)] strains isolated in our hospital's clinical microbiology laboratory at an interval of ten years. Material and Methods: Bacterial strains were identified by conventional methods and BD PhoenixTM Automated Microbiology System (BD Diagnostic Systems, Sparks, MD). Methicillin and fusidic acid susceptibilities of the identified S. aureus strains were determined according to Clinical and Laboratory Standards Institute (CLSI) criteria. In order to determine methicillin and fusidic acid susceptibilities, 1 mu g oxacillin and 10 mu g fusidic acid disks (Oxoid Ltd., Basingstoke, United Kingdom) were used. Oxacillin susceptibility was detected according to the criteria of CLSI, and inhibition zone of >= 13 mm was considered as sensitive, 11-12 mm as intermediate, <= 10 mm as resistant. Fusidic acid susceptibility was detected according to the criteria of Comite de L'antibiogramme de la Societe Francaise de Microbiologie, and inhibition zone of 22 mm was considered as sensitive, 16-21 mm as intermediate, <= 15 mm as resistant. Results: In a study carried out ten years ago, fusidic acid resistance rate in S. aureus strains was reported as 11.6%, whereas in our study it was found as 14.6%. There was not any significant difference between the two resistance rates (p=0.695). Fusidic acid resistance rates were found to be 4.2% and 5.7%, respectively in the years 2001 and 2011 for MSSA strains. In MRSA strains, however, the rates were found as 18.9% and 22.2%, respectively. No significant difference was noted between fusidic acid resistances of MSSA and MASA strains, studied at the two different periods (p=1.00, p=0.906). Conclusion: In the light of these findings, it has been concluded that fusidic acid is still a good alternative drug in the treatment of all staphylococcal infections, including methicillin resistant strains.
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    HISTOLOGICAL OF CHANGES IN THE AMNIOTIC MEMBRANE AND PLACENTAL VILLOUS BASAL LAMINA IN COMPLICATED PREGNANCIES
    (Rojan GÜMÜŞ, 2019) Nergiz, Yusuf; Deveci, Engin; Sak, Muhammet Erdal; Evsen, Mehmet Sıddık; Ekinci, Cenap; Nergiz, Sebnem; Unal, Beyza Karadede
    Aim: This study aimed to histological changes compare placental villous basal lamina and amniotic membrane changes in complicated pregnancy. Methods: Studies were performed on the human placentas, delivered between 24-39 weeks of gestation. Patients were separated equally into 4 groups (Control, preeclampsia (PE), gestastional diabetes (GD), and HELLP syndrome groups)  Placental tissue samples were dissected and fixed in 10% neutral formalin buffer. Routine paraffin tissue protocol was followed. Some of sections were stained with Periodic Acid Schiff. Remaining sections were stained with integrin alpha-6 antibody.To define expression percentage, mean of the staining area/total staining area ratio were calculated. The statistical significance of the expression percentages was compared by One Way ANOVA and Tukey tests with SPSS Statistics V24 software.Results: In PAS-stained preeclamptic, HELLP and gestational diabetes groups placental villous basal lamina and vasculo-syncytial membranes were thicker than the control group. A significant difference was observed in all 3 groups compared to the control group the placental villous basal lamina thickness of the HELLP group was found to be significantly different from all three groups. In chorionic villi of HELLP group, dense integrin expression was found in placental villous basal lamina similar to that in GD and preeclampsia groups. The HELLP group was significantly different from all groups. Conclusion: In preeclampsia, gestational diabetes and HELLP placentas, placental viiöz basal lamina and amniotic membrane significantly thickened and structural changes were observed.
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    Microorganisms Isolated From Burn Wounds and Their Antibiotic Susceptibility
    (Oxford Univ Press, 2008) Mese, Sevim; Nergiz, Sebnem; Gul, Kadri; Girgin, Sadullah
    [Abstract Not Available]
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    Preliminary analysis of Plasmodium vivax genotypes isolated in southeastern Turkey
    (Springer Int Publ Ag, 2015) Doskaya, Aysu Degirmenci; Doskaya, Mert; Caner, Ayse; Gul, Kadri; Nergiz, Sebnem; Can, Huseyin; Guruz, Yuksel
    Plasmodium vivax is the most common cause of malaria worldwide as well as southeastern Turkey. After the implementation of a successful national elimination program that the local malaria cases were not reported in 2011, malaria returned to county of Savur located in southeastern Turkey in summer of 2012. The present study aimed to determine the prevalent P. vivax genotypes isolated from southeastern Turkey. Genetic polymorphism in P. vivax CSP gene was analyzed by PCR-RFLP to assess the ratio of VK210 and VK247 types. Blood samples were obtained from 15 patients who lived in southeastern between 2005-2006. According to the results, VK210 type was detected in 10 samples (66.6%), VK247 type was observed in three samples (20%). Remaining two samples showed mixed infection (13.3%). The results of the present study first time showed the ratio of P. vivax genotypes in southeastern Turkey before the elimination in 2011. The results of the present study will be enable researchers to compare the new isolates with the previously detected ones and design new treatment and/elimination strategies.
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    The Prognostic Nutritional Index and Mortality in Patients With Ventriculoperitoneal Shunt Infection
    (Sage Publications Inc, 2023) Nergiz, Sebnem; Ozturk, Pinar Aydin
    The objective of this study was to investigate the relationship between mortality and the prognostic nutritional index (PNI) in the pediatric patient group with ventriculoperitoneal shunt (VPS) infection. A total of 63 pediatric patients with a VPS infection and positive cerebrospinal fluid (CSF) culture were retrospectively registered. The CSF specimens were analyzed to conduct culture and microscopic evaluation. A total of 44.4% of the cases were men and 55.6% of the cases were women. Patients were divided into 2 groups (survivor and non-survivor patients). When survivor and non-survivor patients were compared, it was found that CSF leukocytes, CSF glucose, CSF protein, CSF/blood glucose ratio, lymphocyte, albumin, and PNI levels were lower in the non-survivor patients' group. Nevertheless, blood glucose and CRP (C-reactive protein) were significantly higher in the non-survivor patients' group than in the survivor patients' group. In our investigation, we suggested that low PNI was related to high mortality in cases of VPS infection.
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    The Relationship between Angiotensin-II Type 1 Receptor Gene Polymorphism and Repolarization Parameters after a First Anterior Acute Myocardial Infarction
    (Korean Soc Cardiology, 2016) Ozturk, Onder; Ozturk, Unal; Nergiz, Sebnem; Karahan, M. Zulkif
    Background and Objectives: Genetic influence on T-wave peak to End (Tpe) time in patients with a first anterior acute myocardial infarction (AMI) is uncertain. A polymorphism in the angiotensin-II type 1 receptor (AT1R) gene was discovered recently. The polymorphism consists of an A or C variant, given three different possible genotypes: AA, AC, CC. The purpose of this study was to determine the effects of polymorphism of the AT1R gene polymorphism on Tpe after a first anterior AMI. Subjects and Methods: The subjects were 142 patients (110 men, 32 women, 58 13 years) with a first anterior AMI; ten patients were excluded from this study. Based on the polymorphism of the AT1R gene, they were classified into two groups: Group 1 (AA genotype) of 91 patients and group 2 (AC and CC genotype) of 41 patients. A 12-lead resting ECG was recorded at admission to the coronary care unit in patients with anterior AMI and were manually measured with a ruler. QTc, QTd, QTcd, Tpe, Tpe/QT parameters were measured. Results: There was no significant difference in the baseline characteristics of patients (p>0.05). We found significant reduction in QTc, QTd, QTcd, Tpe, Tpe/QT indices Group 1 (AA genotype) (mean 66 +/- 28 ms) than group 2 (AC and CC genotype) (mean 95 34 ms) (p<0.05). Conclusion: In patients with a first anterior AMI, AT1R gene polymorphisms may influence on repolarization parameters. Although further studies are required.