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Öğe Can Theranekron be an agent for inducing apoptosis and ER stress in human pancreatic cells(Nature Publishing Group, 2019) Kocak, N.; Duran, T.; Ucar, V. B.; Nergiz, S.; Yildirim, I.[Abstract Not Available]Öğe Determination of serological profiles and avidity of specific antibodies in the sera of patients with potential Epstein-Barr virus (EBV) infection(Comenius Univ, 2013) Akpolat, N.; Gedik, M.; Nergiz, S.; Bilek, H.Background: Epstein Barr Virus, frequently referred to as EBV, is a member of the herpesvirus family and one of the most common human viruses. The virus occurs worldwide, and most people become infected with EBV sometime during their lives. Objectives: The purpose of this study was to investigate the serological profiles of specific antibodies among the sera of suspected EBV infection patients along with VCA-IgG avidity. Methods: A total of 522 patient's sera were sent to The Clinical Microbiology Laboratory for EBV specific antibody detection and were studied by IFA method during a two year period. The serum samples were tested for EBV specific VCA IgG, VCA IgM, EA, EBNA antibodies and VCA IgG aviditity. Results: Among 33 patients those who had low avidity for VCA IgG, 27 (81.8 %) of them had a serologic profile as follows; positive VCA IgG, negative VCA IgM, negative EA and negative EBNA. Conclusion: While this profile is considered as a primary infection, the frequency of the coexistence of VCA IgG low avidity with this profile is interepreted that avidity may lead to detect primary infection (Tab. 2, Ref. 25). Full Text in PDF www.elis.sk.Öğe Effects of N-acetyl-cysteine and acetylsalicylic acid on the tonsil bacterial biofilm tissues by light and electron microscopy(Verduci Publisher, 2014) Bulut, F.; Meric, F.; Yorgancilar, E.; Nergiz, Y.; Akkus, M.; Nergiz, S.; Nasir, Y.OBJECTIVE: The present study aimed to investigate the effects of the bacterial biofilm formation on the tonsil surface exposed N-acetyl-cysteine (NAC) and acetylsalicylic acid (ASA) of patients undergoing tonsillectomy by light and electron microscopy. The general process of biofilm formation comprises adhesion of free-living or planktonic bacteria to a surface, which subsequently develop into microcolonies and form a biofilm. Based on studies that have shown the presence of biofilms in common sites of chronic infections, it has become clear that bacteria may persist on mucosal surfaces through formation of biofilms. PATIENTS AND METHODS: Ten patients between 4 and 39 years of age (mean, 11.9 +/- 11.2 years). In all cases, periodic acide Schiff (PAS) staining was found to be an accurate predictor of the presence or absence of biofilm using light microscopy as a control standard. Therapeutic doses of NAC and ASA were identificated as the effective on the tonsil bacterial biofilm using light and electron microscopy. RESULTS: Biofilm formation was detected on all samples. Tonsils removed from patients with ASA-10 had showed higher-grade inhibitory effect at the biofilm formation than the other group (p <= 0.0001). The correlation was found between drug dose and decrease at the biofilm formation. CONCLUSIONS: In chronic or recurrent tonsillitis patients, decrease on the tonsils surface biofilm formation may be associated with ASA dose. Whether effect on the tonsils surface biofilm formation of other agent have a role is not known.Öğe Relation between right atrial speckle tracking echocardiography and p-wave dispersion in patients with a percutaneous closure of atrial septal defect(Oxford Univ Press, 2017) Ozturk, O.; Ozturk, U.; Nergiz, S.; Ozturk, S.[Abstract Not Available]
