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    Behcet's disease as a causative factor of cerebral venous sinus thrombosis: subgroup analysis of data from the VENOST study
    (Oxford Univ Press, 2019) Uluduz, Derya; Midi, Ipek; Duman, Taskin; Colakoglu, Sena; Tufekci, Ahmet; Bakar, Mustafa; Nazliel, Bijen
    Objective This study was performed to determine the rate of cerebral venous sinus thrombosis (CVST) among cases of Behcet's disease (BD) included in a multicentre study of cerebral venous sinus thrombosis (VENOST). Methods VENOST was a retrospective and prospective national multicentre observational study that included 1144 patients with CVST. The patients were classified according to aetiologic factors, time of CVST symptom onset, sinus involvement, treatment approach and prognosis. Results BD was shown to be a causative factor of CVST in 108 (9.4%) of 1144 patients. The mean age of patients in the BD group was 35.27 years and 68.5% were men, whereas in the non-BD CVST group, the mean age was 40.57 years and 28.3% were men (P < 0.001). Among the aetiologic factors for patients aged 18-36 years, BD was predominant for men, and puerperium was predominant for women. The onset of symptoms in the BD group was consistent with the subacute form. The transverse sinuses were the most common sites of thrombosis, followed by the superior sagittal sinuses. The most common symptom was headache (96.2%), followed by visual field defects (38%). Conclusions BD was found in 9.4% of patients in our VENOST series. Patients with BD were younger and showed a male predominance. The functional outcome of CVST in patients with BD was good; only 12% of patients presenting with cranial nerve involvement and altered consciousness at the beginning had a poor outcome (modified Rankin Score 2).
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    Headache as the sole presenting symptom of cerebral venous sinuses thrombosis: Subgroup analysis of data from the VENOST study
    (Kare Publ., 2021) Duman, Taşkın; Çınar, Nilgün; Uludüz, Derya; Domaç, Füsun Mayda; Öztürk, Şerefnur; Yayla, Vildan; Karahan, Ali Yavuz; Afşar, Nazire; Sungur, Mehmet Ali; Göksu, Eylem Özaydın; Yürekli, Vedat Ali; Genç, Hamit; Utku, Uygar; Şahin, Şevki; Tekeli, Hakan; Tokuç, Firdevs Ezgi; Uzuner, Nevzat; Şenol, Mehmet Güney; Yılmaz, Arda; Gökçe, Mustafa; Demirci, Seden; Küsbeci, Özge Yılmaz; Uzuner, Gülnur Tekgöl; Çağlayan, Hale Zeynep Batur; Açıkgöz, Mustafa; Kurucu, Hatice; Özdağ, Mehmet Fatih; Baybas, Sevim; Ekmekçi, Hakan; Çabalar, Murat; Yaman, Mehmet; Bektaş, Hesna; Kaplan, Yüksel; Göksel, Başak Karakurum; Milanlıoğlu, Aysel; Örken, Dilek Necioğlu; Aluçlu, Mehmet Ufuk; Çolakoğlu, Sena; Tüfekçi, Ahmet; Bakar, Mustafa; Nazliel, Bijen; Taşçılar, Nida; Göksan, Baki; Kozak, Hasan Hüseyin; Mısırlı, Cemile Handan; Küçükoğlu, Hayriye; Midi, Ipek; Mengüllüoğlu, Necdet; Aytaç, Emrah; Yeşilot, Nilüfer; İnce, Birsen; Yalın, Osman Özgür; Güneş, Taşkın; Oruç, Serdar; Demir, Serkan
    Objectives: Headache is the most common complaint in cerebral venous sinus thrombosis (CVST) and it may sometimes be the only symptom in these patients. This retrospective and prospective study was an investigation of any differences in terms of clinical risk factors, radiological findings, or prognosis in patients with CVST who presented with isolated headache (IH) and cases with other concomitant findings (non-isolated headache [NIH]). Methods: A total of 1144 patients from a multicenter study of cerebral venous sinus thrombosis ( VENOST study) were enrolled in this research. The demographic, biochemical, clinical, and radiological aspects of 287 IH cases and 857 NIH cases were compared. Results: There were twice as many women as men in the study group. In the IH group, when gender distribution was evaluated by age group, no statistically significant difference was found. The onset of headache was frequently subacute and chronic in the IH group, but an acute onset was more common in the NIH group. Other neurological findings were observed in 29% of the IH group during follow-up. A previous history of deep, cerebral, or other venous thromboembolism was less common in the IH group than in the NIH group. Transverse sinus involvement was greater in the IH group, whereas sagittal sinus involvement was greater in the NIH group. The presence of a plasminogen activator inhibitor (PAI) mutation was significantly greater in the IH group. Conclusion: IH and CVST should be kept in mind if a patient has subacute or chronic headache. PAI, which has an important role in thrombolytic events, may be a risk factor in CVST. Detailed hematological investigations should be considered. Additional studies are needed.