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    Öğe
    Is Diabetes Mellitus a Prognostic Factor for Survival in Patients with Small Cell Lung Cancer?
    (Asian Pacific Organization Cancer Prevention, 2012) Inal, Ali; Kaplan, M. Ali; Kucukoner, Mehmet; Urakci, Zuhat; Karakus, Abdullah; Nas, Necip; Guven, Mehmet
    Background: Previous studies have pointed to many different prognostic factors for small cell lung cancer (SCLC) but diabetes mellitus (DM) has not been clearly or consistently identified as of prognostic value. The aim of this study was to investigate the prognostic significance of the characteristics of patients and clinical laboratory tests in SCLC. Specifically, we investigated that the impact of DM for survival in the patients receiving first-line etoposide plus cisplatin (EP) chemotherapy. Methods: We retrospectively reviewed 161 patients with SCLC with a focus on DM and other potential prognostic variables were chosen for univariate and multivariate analyses with respect to survival. Result: Among the sixteen variables of univariate analysis, five were identified to have prognostic significance: performance status (PS) (p < 0.001), stage (p=0.001), DM (p=0.005), serum albumin (p < 0.001) and hemoglobin levels (p=0.03). Multivariate analysis showed PS, stage and serum albumin level to be independent prognostic factors for survival (p=0.02, p=0.02 and p=0.009 respectively), but DM was not an independnet factor. Conclusion: In conclusion, PS, stage and serum albumin level were identified as important prognostic factors, while DM at the time of diagnosis of SCLC did not have prognostic importance for survival.
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    Öğe
    Is fat mass more effective than body mass index (BMI) to predict toxicity in early breast cancer patients treated with doxorubicin and cyclophosphamide?
    (Amer Assoc Cancer Research, 2018) Kaplan, Muhammet Ali; Kavak, Hemrin; Urakci, Zuhat; Nas, Necip; Oruc, Zeynep; Yerlikaya, Halis; Akdeniz, Nadiye
    [Abstract Not Available]
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    Öğe
    Kolorektal kanserler: Tek merkez 12 yıllık sonuçları
    (2013) Önder, Akın; Küçüköner, Mehmet; Büyükbayram, Hüseyin; Kaplan, M.Ali; Nas, Necip; Urakçı, Zuhat; Keleş, Ayşenur
    Amaç: Bu çalışmamızda kliniğimizde takibi yapılmış olankolorektal kanserli hastaların demografik, epidemiyolojik, klinik özellikleri ve sağkalımını etkileyen faktörlerin retros-pektif olarak belirlenmesi amaçlanmıştır.Yöntemler: Dicle Üniversitesi Tıp Fakültesi Tıbbi Onko-loji Bilim Dalı’nda 2000- 2012 tarihleri arasında takip edil-miş 767 kolorektal kanser tanılı hasta retrospektif olarakdeğerlendirildi.Bulgular: Çalışmada hastaların 432’si (%56,3) erkek, 335’i( %43,7) kadın olup ortanca yaş 54 (11-94) idi. Ev- resine bakılan 725 hastanın 57’si (%7,9) evre I, 230’u (%31,7) evre II, 248’i (%34,2) evre III ve 190’u (%26,2) evre IV olarak tespit edildi. Tüm hastaların ortanca takip süresi 24.8 (1.5-154.1) aydı. Hastaların 275’inde (%35.9) nüks veya progresyon, 184’ünde (%24) ölüm gözlendi. Hastalıksız sağkalım oranları (HSK) %1,3 ve 5 yıllık %81, %62 ve %29 iken, genel sağkalım (GSK) oranları 1,3 ve 5 yıllık %88, %74 ve %49 idi. Yaş grubuna göre değer- lendirildiğinde 60 yaş ve altında olan hasta grubunda 60 yaş üstü gruba kıyasla hem HSK hem de GSK daha iyiydi (p=0.053 ve p=0.024). Evre ile HSK ve GSK arasında- da anlamlı farklılıklar görüldü (p<0.001 ve p<0.001). Tü- mör diferansiyasyon derecesi de HSK üzerinde etkilydi (p=0.027). Yapılan multivaryant cox regresyon analizde evrenin hem HSK hem de GSK açısından bağımsız prog- nostik faktör olduğu görüldü (p<0,001, p<0,001). Sonuç: Bölgemizde başvuran hastaların çoğunluğu %60,4 ile lokal ileri ve metastatik evredeydi. Evre, histo- lojik grade ve ileri yaş, hem hastalıksız sağkalım hem de genel sağkalım üzerine etkili prognostik faktörler olarak bulundu. Multivariyant analizde evre hem genel sağkalım hem de hastalıksız sağkalım açısından bağımsız prog- nostik faktör olduğu görüldü.
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    Öğe
    Prognostic Factors in First-Line Chemotherapy Treated Metastatic Gastric Cancer Patients: A Retrospective Study
    (Asian Pacific Organization Cancer Prevention, 2012) Inal, Ali; Kaplan, M. Ali; Kucukoner, Mehmet; Urakci, Zuhat; Guven, Mehmet; Nas, Necip; Yunce, Muharrem
    Background: The majority of patients with gastric cancer in developing countries present with advanced disease. Systemic chemotherapy therefore has limited impact on overall survival. Patients eligible for chemotherapy should be selected carefully. The aim of this study was to analyze prognostic factors for survival in advanced gastric cancer patients undergoing first-line palliative chemotherapy. Methods: We retrospectively reviewed 107 locally advanced or metastatic gastric cancer patients who were treated with docetaxel and cisplatin plus fluorouracil (DCF) as first-line treatment between June 2007 and August 2011. Twenty-eight potential prognostic variables were chosen for univariate and multivariate analyses. Results: Among the 28 variables of univariate analysis, nine variables were identified to have prognostic significance: performance status, histology, location of primary tumor, lung metastasis, peritoneum metastasis, ascites, hemoglobin, albumin, weight loss and bone metastasis. Multivariate analysis by Cox proportional hazard model, including nine prognostic significance factors evident in univariate analysis, revealed weight loss, histology, peritoneum metastasis, ascites and serum hemoglobin level to be independent variables. Conclusion: Performance status, weight loss, histology, peritoneum metastasis, ascites and serum hemoglobin level were identified as important prognostic factors in advanced gastric cancer patients. These findings may facilitate pretreatment prediction of survival and can be used for selecting patients for treatment.