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Öğe Fever due to malaria in a neutropenic patient. A rare complication of blood transfusion(Saudi Med J, 2004) Isikdogan, A; Ayyildiz, O; Soker, M; Yakut, M; Muftuoglu, E[Abstract Not Available]Öğe Fludarabine as a second-line treatment of advanced stage chronic lymphocytic leukemia(Saudi Med J, 2004) Ayyildiz, O; Isikdogan, A; Bolaman, Z; Muftuoglu, E[Abstract Not Available]Öğe Hepatitis C virus in patients with non-Hodgkin's lymphoma in southeastern Anatolia region of Turkey: A prospective case-control study of 119 patients(Taylor & Francis Ltd, 2003) Isikdogan, A; Ayyildiz, O; Dursun, M; Tiftik, N; Batun, S; Muftuoglu, EHepatitis C virus (HCV) has been associated with several extrahepatic disorders including mixed cryoglobulinemia (MC), autoimmune thyroiditis, Sjogren's syndrome. Such associations have led to the suggestion that HCV may participate in the development of various immunmediated disorders. Recently, it has been hypothesised that HCV might act as a trigger for the development of monoclonal B-cell disorders such as non-Hodgkin's lymphoma (NHL). Discordant data have been reported in different geographic regions of the world. The aim of this prospective case-control study was to detect the prevalence of HCV in patients with NHL in southeastern Anatolia region of Turkey. In this study, HCV antibody prevalence and cryoglobulinemia were investigated in 119 patients with histologically diagnosed NHL. The control group consisted of 117 patients who visited the outpatient clinic of internal medicine. None of the patients had HCV antibody positive (0%) with the enzyme immunoassay and reverse transcriptase polymerase chain reaction (RT-PCR). One of the control patients had positive HCV antibody (0.9%). Our data does not support the association between HCV infection and NHL in southeastern Anatolia region of Turkey.Öğe The importance of CD7 and CD56 antigens in acute leukaemias(Wiley, 2004) Tiftik, N; Bolaman, Z; Batun, S; Ayyildiz, O; Isikdogan, A; Kadikoylu, G; Muftuoglu, EThe prognostic significance of immunophenotypical properties of leukaemic cells is well known. However, the biological and clinical significance of CD7 and CD56 antigen expression in acute leukaemias are not clearly established. In patients with acute leukaemias, we identified CD7 and CD56 expression and analysed their associations with markers expressed early in haemopoietic ontogeny and clinical parameters. Among 22 patients with acute leukaemia [12 acute myeloblastic leukaemia (AML), 10 acute lymphoblastic leukaemia (ALL)], we found CD7 positivity in 15 of 22 patients (68%) and CD56 positivity in four patients (18%). CD7 positivity was observed in seven patients (58%) with AML and in eight patients (80%) with ALL. CD56 positivity was observed in three patients (25%) with AML and one patient (10%) with ALL. Lymphadenopathy was present in five patients and associated with hepatosplenomegaly in three patients with ALL. Splenomegaly and hepatomegaly were present in three patients with AML. Central nervous system involvement was seen in one patient with ALL. Complete remission was achieved in nine patients (41%) (five ALL and four AML). Our data showed that CD7 and CD56 positivity at diagnosis associated with low remission rate and biological aggressiveness in a significant proportion of patients. We suggest the evaluation of CD7 and CD56 in all patients with acute leukaemias at the time of diagnosis in view of poor clinical outcome.Öğe Intracranial meningeal extramedullary hematopoiesis inducing serious headache in a patient with idiopathic myelofibrosis(Lippincott Williams & Wilkins, 2004) Ayyildiz, O; Isikdogan, A; Celik, M; Muftuoglu, E[Abstract Not Available]Öğe Molecular basis of ?-Thalassemia mutations in Diyarbakir in the southeastern region of Turkey(Marcel Dekker Inc, 2003) Ince, HH; Ayyildiz, O; Kalkanli, S; Batun, S; Muftuoglu, E[Abstract Not Available]Öğe Non-Hodgkin's lymphoma in southeast Turkey: clinicopathologic features of 490 cases(Springer, 2004) Isikdogan, A; Ayyildiz, O; Buyukcelik, A; Arslan, A; Tiftik, N; Buyukbayram, H; Muftuoglu, EWe have carried out a retrospective analysis of 490 non-Hodakin's lymphomas (NHLS), followed at our clinic, with the purpose of evaluating the clinicopathologic features of these patients. The patients were assessed with regard to their characteristics including age gender. histologic distribution, stage, extranodal involvement. presenting symptoms, and biopsied site. Of the patients 314 (64%) were male and 176 (36%) were female. The overall median age was 43 years (range: 1490). The patients were classified according to the Working Formulation (WF) system: 71 (14.4%) were low grade, 342 (69.8%) were intermediate grade, 43 (8.7%) were high grade, and 34 (6.7%) had other lymphomas. Intermediate-grade non-Hodgkin's lymphomas formed the largest group, of whom 320 patients' paraffin blocks were available for Revised European and American lymphoma (REAL) classification: 78% were B-cell lymphomas, whereas 16% were T/NK lymphomas. Six percent of cases were unclassified lymphomas. Diffuse large B-cell lymphoma (DLBCL) was the most commonly observed histopathologic type in 132 (41%) patients. Extranodal involvement was found in 218 (44.5%) patients. The most commonly affected extranodal sites were small bowel, stomach, and tonsil in 72 (33%), 63 (29%), and 19 (8.7%) patients, respectively. According to the Ann Arbor staging system, the vast majority of patients (89.4%) were advanced stage. In conclusion, the characteristics of NHLs in our region show some differences from the other sites of Turkey and the world.
