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Öğe Fibrosis in heart failure subtypes(Verduci Publisher, 2013) Toprak, G.; Yuksel, H.; Demirpence, O.; Islamoglu, Y.; Evliyaoglu, O.; Mete, N.BACKGROUND: The differences in concentrations of biomarkers between heart failure patients with dilated cardiomyopathy (HF-D) and with ischemic cardiomyopathy (HF-I) have yet to be defined. The objectives of this study were to compare the concentrations and correlation of biomarkers of inflammation, extracellular matrix (ECM) turnover and oxidative stress parameters between these populations. PATIENTS AND METHODS: Our study consisted of 36 subjects with HF-D (LVSD = 47.2 +/- 7.3 mm, LVDD = 65.1 +/- 6.3 mm), 44 subjects with HF-I (LVSD = 38.0 +/- 4.4 mm, LVDD = 58.5 +/- 6.0 mm) and 38 controls without heart failure. Concentrations of matrix metalloproteinase (MMP)-1, MMP-2, MMP-9, MMP-13, Galectin-3, prolidase, TNF-alpha, and oxidative stress index (OSI) were measured. RESULTS: Serum levels of MMP-2, MMP-9, and prolidase were significantly increased in HF-I group compared to healthy controls (p = 0.039, 0.019, 0.012 respectively), whereas the increases in MMP-1 and MMP-13 were not significant. This significance was stronger in the HF-D group than the HF-I group (p = 0.004, 0.001, 0.002 respectively). TNF-alpha, a marker of inflammation, was significantly increased in heart failure (p = 0.004) but there was no difference between HF-D and HF-I groups; however, Galectin-3 was significantly increased in the HF-D group compared to the HF-I group (p = 0.005). OSI showed the same response pattern as TNF-alpha (p = 0.019, 0.002 respectively). There was a positive correlation of MMP-9 levels with prolidase activity (r = 0.612, p: 0.003). CONCLUSIONS: MMPs and Galectin-3 are important in cardiac remodeling; prolidase may share an undefined role in fibrosis in heart failure and may have a role in the diffuse fibrosis of heart failure.Öğe P53 gene exon 4 RFLP polymorphism and relation with severity of disease in patients with coronary artery disease(Blackwell Publishing, 2006) Cakir, D. U.; Yokus, B.; Tekes, S.; Iltimur, K.; Mete, N.; Uysal, E.[Abstract Not Available]Öğe THE ROLE OF ENDOTHELIAL NITRIC OXIDE SYNTHASE GENE POLYMORPHISM IN CLINICALLY CLASSIFIED PATIENTS WITH CORONARY ARTERY DISEASE(Taylor & Francis Ltd, 2010) Cakir, D. U.; Mete, N.The aim of the study was to investigate the relationship of eNOS (4 intron 27bp) polymorphism in clinically classified patients with coronary artery disease (CAD) in Turkish population PCR and restriction fragment length polymorphism analysis were used to detect the variant of the eNOS gene in 74 patients' with CAD and 20 healthy controls The CAD group was separated into 3 clinical groups depending on angiography criteria and clinical form designation 1st Group Myocardial infarction (MI) (n 20) 2nd Group Unstable Angina Pectoris (UAP) (n 18) 3rd Group Stable Angina Pectoris (SAP) (n 36) When a and b allele frequencies in the CAD and control groups we, e compared no statistically significant difference was found No significant difference was observed in the 4 intron 27 bp variants of the eNOS gene when CAD patients were compared without distinguishing them clinically from the control group When we assessed CAD patients classified according to their clinical form no significant difference was determined in allele frequencies and genotype distribution in the subgroups except for subgroup S4P When we compared SAP patients with the other subgroups and with the control group it was found that there was a significant increase in the ab genotype and the a allele frequency and a decrease in the bb genotype (p < 0 05) In conclusion CAD seemed to develop without any alterations in eNOS (4 intron 27bp) genotype frequency However the 27 bp repeat polymorphism of the eNOS gene in patients with SAP can be considered as SAP which may have a hereditary origin High eNOS gene polymorphism in patients with SAP can be related to the increased risk of possible coronary occurrence in future It was concluded that further studies of the relationship between eNOS gene polymorphism and CAD should take account of the clinical forms of CADÖğe The role of nitric oxide synthase (eNOS) gene polymorphism in coronary artery diseases and relation with severity of disease(Blackwell Publishing, 2006) Tekes, S.; Cakir, D. U.; Yokus, B.; Mete, N.; Iltimur, K.[Abstract Not Available]Öğe THE ROLE OF RELAXIN IN BENIGN HYPERMOBILITY SYNDROME(Bmj Publishing Group, 2013) Em, S.; Oktayoglu, P.; Caglayan, M.; Karakoc, M.; Ucar, D.; Bozkurt, M.; Mete, N.[Abstract Not Available]Öğe SERUM LEVELS OF HIGH MOBILITY GROUP BOX 1 PROTEIN AND ITS ASSOCIATION WITH QUALITY OF LIFE AND PSYCHOLOGICAL AND FUNCTIONAL STATUS IN PATIENTS WITH FIBROMYALGIA(Bmj Publishing Group, 2013) Oktayoglu, P.; Caglayan, M.; Bozkurt, M.; Em, S.; Ucar, D.; Yazmalar, L.; Mete, N.[Abstract Not Available]Öğe Total antioxidant response and oxidative stress index and relation with severity of disease in coronary artery disease(Blackwell Publishing, 2006) Mete, N.; Cakir, D. U.; Yokus, B.; Iltimur, K.[Abstract Not Available]Öğe A USEFUL MARKER IN ASSESSMENT OF REMISSION AND ACTIVATION OF DISEASE IN PATIENTS WITH RHEUMATOID ARTHRITIS: SERUM HUMAN NEUTROPHIL PEPTIDES 1-3(Bmj Publishing Group, 2016) Okcu, M.; Oktayoglu, P.; Mete, N.; Bozkurt, M.; Caglayan, M.; Nas, K.[Abstract Not Available]
