Yazar "Mahomoodally, Fawzi M." seçeneğine göre listele

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    Chemical profile, antioxidant properties and enzyme inhibitory effects of the root extracts of selected Potentilla species
    (Elsevier B.V., 2019) Uysal, Şengül; Zengin, Gökhan; Mahomoodally, Fawzi M.; Yılmaz, Mustafa Abdullah; Aktümsek, Abdurrahman
    Plants from the genus Potentilla have been traditionally used for therapeutic purposes in Turkey. Methanol root extracts from four selected Potentilla species (P. anatolica, P. argentea, P. recta, and P. reptans) were probed for their chemical composition, antioxidant properties (DPPH, ABTS, FRAP, CUPRAC, phosphomolybdenum, and metal chelating activity), and enzyme (acetylcholinesterase (AChE), butyrylcholinesterase (BChE), α-amylase, α-glucosidase, and tyrosinase) inhibition effects. In addition, the total phenolic, flavonoid, saponin, and triterpenoid content of the extracts were determined. Ultra-high performance liquid chromatography (UHPLC)-electrospray ionization (ESI)-tandem mass spectrometry (MS/MS) analysis revealed that the main phenolic components in extracts were coumarin, hesperidin, p-coumaric acid, gallic acid, and rutin. P. recta and P. reptans showed the highest total phenolic, saponin, and triterpenoid content. The root extracts showed significant antioxidant properties and depicted significant inhibitory effects against AChE, BChE, α-amylase, α-glucosidase, and tyrosinase. In conclusion, root extracts of Potentilla may be considered as new natural antioxidants and key enzyme inhibitors that can be exploited as bioproducts for pharmaceutical industries
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    A comparative bio-evaluation and chemical profiles of Calendula officinalis L. extracts prepared via different extraction techniques
    (MDPI AG, 2020) Ak, Guneş; Zengin, Gökhan; Kouadio İbrahime, Sinan; Mahomoodally, Fawzi M.; Picot-Allain, Marie Carene Nancy; Çakır, Oğuz; Bensari, Souheir; Yilmaz, Mustafa Abdullah; Gallo, Monica; Montesano, Domenico
    Calendula officinalis L., (marigold), well known for its medicinal properties, has been extensively studied for its therapeutic properties. Nonetheless, as far as the literature could establish, no study has attempted to comparatively assess the biological (antioxidant and enzyme inhibitory potential) of the flowers, leaves, and roots of C. officinalis extracted using conventional (maceration and Soxhlet extraction (SE)) and non-conventional extraction (homogenizer (HAE) and ultrasound (UAE) assisted extraction) techniques. The detailed phytochemical profile of each extract along with the concentration of specific bioactive compounds has also been established. Total phenolic content was highest for the flower extracts while flavonoid content was highest in the leaf extracts. Phytochemical profiling showed that the extraction method influenced the phytochemical composition of the extract. Nicotiflorin was identified in the flower extracts only while amentoflavone occurred only in the roots, inferring that the occurrence of bioactive compounds varies within a plant. The flower extracts showed highest antioxidant potential while the roots extracts were potent inhibitors of cholinesterase and tyrosinase. This study provides valuable data on the influence of extraction techniques on the recovery of bioactive compounds from plants. In an endeavor to scale-up extraction from plant considering the more efficient extraction method is of paramount importance. Moreover, the study highlighted the necessity to thoroughly examine the biological activities of various parts of a plant obtained via different extraction protocols.