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Öğe Acquired Glanzmann thrombastenia due to immune thrombocitopenic purpura(2006) Altintaş A.; Ayyildiz O.; Söker M.; Müftüoğlu E.Glanzmann thrombastenia is a rare otosomal ressesive disease which has normal platelet count and morphology, and impairment of platelet aggregation. There is qualitative or quantitative abnormality in GPIIb-IIIa proteins that have a function of receptor to fibrinogen and Von-Willebrand Factor. Mucocutenous hemorrhage, epistaxis, gingival hemorrhage, and hemorrhage were seen especially in young age. The disease may occur rarely as an acquired. Autoantibodies developed in the course of some disease such as Non-hodgkin's lymphoma, Hodgkin disease, multiple myeloma, in patients who are taking immunusuppressive drugs, and particularly in immune thrombocytopenic purpura. We report here, a patient 42 years-old female, who is diagnosed as Acquired Glanzmann thrombastenia due to immune thrombocytopenia.Öğe Autoimmune hemolytic anemia presented in course of Hodgkin's diseases: Report of two cases(2006) Altintaş A.; Ayyildiz O.; Işikdoğan A.; Atay E.; Müftüoğlu E.Autoimmune hemolytic anemia is a rare disorder that the incidence is approximately 1/100000 in adults. 50-70 % of cases are idiopathic. Recently, the percentages of secondary causes have risen due to detailed investigation and long term follow up. Hematologic and nonhematologic malignancies plays an important role in the etiology and pathogenesis of autoimmune hemolytic anemia that has many other causes. Lenfoproliferative malignencies, especially chronic lenfoid leukemia is the most striking disease. The association of Hodgkin's disease and autoimmune hemolytic anemia is being observed as rare case reports. We discussed two cases of Hodgkin's disease associated autoimmune hemolytic anemia in recent 3 years period. One was presented after therapy and the other was presented prior to therapy.Öğe Cladribine treatment outcomes of hairy cell leukemia(2006) Altintaş A.; Ayyildiz O.; Atay A.E.; Çil T.; Müftüoğlu E.Hairy cell leukemia is a rare, clonal, chronic B cell lenfoproliferative disease characterized by splenomegaly and pancytopenia. Purine analogues are first-line choice of therapy. Although effectivity of treatment is established, relapses may occur. In this state, remission may achieved by a new cycle of 2-CdA or alternative modalities. In this report, we represented the results of our patients with HCL that were treated with 2-CdA and followed up in our center.Öğe Differential diagnosis of Churg Strauss syndrome: Two cases reports(2007) Altintaş A.; Çil T.; Ayyildiz O.; Şit D.; Müftüoğlu E.Churg-Strauss syndrome (CSS) is characterized by necrotising, eosinophilic-rich granulomatous inflammation of small and medium vessels. Differantial diagnosis with Hypereosinophilic syndrome is crucial. Herein, we presented two patients with eosinophilia and eosinophilia related organ damage and emphasize the clinical properties and differential diagnosis of CSS and Hypereosinophilic syndrome; which has many similarities.Öğe Öğe Inhibitors in hemophilia A and B in Southeast of Turkey(2006) Altintaş A.; Ayyildiz O.; Çil T.; Söker M.; Müftüoğlu E.Hemophilia A and B are inherited, X chromosome linked coagulation disorders that characterized by clinical signs and symptoms seen in males. The most important treatment related complication was viral infection in the past years, but this problem is overcoming by developing of modern factors concentrate which are available in the market, nowadays. However, developing inhibitor against concentrated factors that used is the most important problem, as in western countries. In this study, we aimed to evaluate the inhibitor developing rate in 73 hemophiliac pediatric and adult patients who have treated and followed up in Dicle University hematology polyclinics in Southeastern Anatolia. 62 (85%) of cases were hemophilia A and 11 (15%) were hemophilia B. Of hemophilia A patients 41 (66.2%) had severe and 17 (27.4%) had moderate disease. The same rates were 7 (63.6%) and 3 (27.3%) in hemophilia B patients, respectively. Only one patient (2.4%) with severe hemophilia A had high titrate of inhibitor positivity (17 BU/ml). Inhibitor was present in any of hemophilia B patients. This rate was lower than previously reported data from community of Turkey. We proposed that the most important cause of this low frequency of inhibitor is using fresh frosen plasma in treatment of those patients with bleeding.Öğe Thrombotic thrombocytopenic purpura associated with Graves' disease(2007) Altintaş A.; Çil T.; Ayyildiz O.; Kaplan M.A.; Müftüoğlu E.Thrombotic thrombocytopenic purpura (TTP) is characterized by microangiopathic hemolytic anemia and thrombocytopenia, usually accompanied by fever, renal failure and neurological deficits. TTP usually occurs in previously healthy people, but in a significant number of cases, the syndrome is associated with autoimmune disorders. We report a case of a 53 year old male patient suffering from TTP associated with Graves' disease (GD). After the diagnosis of TTP and Graves' disease plasmapheresis and antithyroid therapy were initiated. After the 15th seans of plasmapheresis, complaints were dissolved and hematologic parameters were recovered. This case draws the reader's attention to a rare condition that TTP associated with GD. Although immune thrombocytopenic purpura (ITP) and pernisious anemia must be initially considered in the event that thrombocytopenia accompanies to GD, TTP is likely in the presence of microangiopathy. The presence of microangiopathic haemolytic anemia and thrombocytopenia is sufficient for the diagnosis of TTP, thus prompt diagnosis and appropriate therapy is crucial for TTP.
