Yazar "Kuyumcu, Mahir" seçeneğine göre listele
Listeleniyor 1 - 11 / 11
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe COVID-19 yoğun bakım ünitelerinde hava yolu yönetimi(Dicle Üniversitesi Tıp Fakültesi, 2021) Kuyumcu, MahirÇin’in Wuhan şehrinde ilk olarak tespit edilen Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) tespit edildikten kısa süre sonra tüm dünyada ve ülkemizde de vakalar tespit edilmiştir. Vaka sayılarının artmasıyla hastalığın şiddetine göre önce yataklı servislerde daha sonra da yoğun bakım ünitelerinde yoğunluklar yaşanmıştır. Covıd-19 enfeksiyonu olan kişilerin ülkeden ülkeye hatta bölgesel olarak farklılık göstermekle birlikte %20-26’lık bir kısmı hastanelere solunum sıkıntısı şikayetleri ile başvurmakta bu hastalarında %5-10’luk kısmının yoğun bakım ihtiyacı olduğu bildirilmektedir. Covid-19 pandemisi ARDS ve multiorgan yetmezliklerine neden olarak hastalarda mekanik ventilatör ihtiyacı ve 3. basamak yoğun bakım takibi gerektirmektedir. Bu nedenle hastalığın bilinen spesifik tedavisi olmamasına rağmen yoğun bakım ünitelerinde sağlanan destek tedavisi ile hastalığın seyrindeki morbibite ve mortalite üzerine etkili olunmaktadır. Bu yazımızda akut solunum sıkıntısı olan ve solunum desteğine ihtiyaç duyan yeni tip koronavirüs enfeksiyonu hastalarına verilen solunum desteği ve hava yolu yönetimi anlatmayı amaçlıyoruz.Öğe Dexmedetomidine and Magnesium Sulfate: A Good Combination Treatment for Acute Lung Injury?(Taylor & Francis Inc, 2019) Guzel, Abdulmenap; Dogan, Erdal; Turkcu, Gul; Kuyumcu, Mahir; Kaplan, Ibrahim; Celik, Feyzi; Yildirim, Zeynep BaysalObjectives: In this study, we aimed to investigate the therapeutic effects of magnesium sulfate (MgSO4) and dexmedetomidine (dex) in a model of acute lung injury (ALI). We determined whether concomitant administration decreased the inflammatory effects of hydrochloric acid (HCl)-induced ALI in a synergistic manner. Materials and Methods: In this study, 42 Sprague-Dawley rats were randomized into six groups: Group S (saline), Group SV (saline + mechanical ventilation), Group HCl (HCl), Group Dex (Dex), Group Mag (MgSO4), and Group DM (Dex + MgSO4). All groups except Group S were mechanically ventilated prior to HCl-induced ALI. Saline or HCl was administered via tracheostomy. Prior to treatment, HCl was administered to Group HCl, Group Dex, Group Mag, and Group DM to induce ALI. Dex and MgSO4 were administered intraperitoneally. The rats were monitored for 4 h after treatment to measure oxidative stress parameters in blood, and prolidase enzyme activity. Lung tissue damage were determined via histopathology. Results: A significant increase in heart rate and rapid desaturation was observed in HCl-administered groups. Treatment administration decreased the pulse values. Increased saturation values and decreased oxidative stress indices were observed in groups that were subsequently administered Dex and MgSO4. Serum prolidase activity increased significantly in Group HCl. Severe pathological findings were detected following HCl-induced ALI. Group Mag showed greater improvement in the pathology of HCl-induced ALI than did Group Dex. Administration of both Dex and MgSO4 did not improve the pathological scores. Conclusions: The antioxidant and anti-inflammatory effects of Dex and MgSO4 ameliorated the detrimental effects of HCI-induced ALI. However, adverse effects on hemodynamics and lung damage were observed when the two drugs were administered together.Öğe Effects of Hyperbaric Oxygen Treatment on Renal System(Iranian Soc Nephrolgy, 2017) Tezcan, Orhan; Caliskan, Ahmet; Demirtas, Sinan; Yavuz, Celal; Kuyumcu, Mahir; Nergiz, Yusuf; Guzel, AbdulmenapIntroduction. Hyperbaric oxygen (HBO) treatment is steadily increasing as a therapeutic modality for various types of diseases. Although good clinical outcomes were reported with HBO treatment for various diseases, the multisystemic effects of this modality are still unclear. This study aimed to investigate the renal effects of HBO experimentally. Materials and Methods. Fourteen New Zealand White rabbits were divided into 2 groups randomly as the control group and the study group. The study group received HBO treatment for 28 days (100% oxygen at 2.5 atmospheres for 90 minutes daily) and the control group was used to obtain normal renal tissue of the animal genus. After the intervention period, venous blood samples were obtained, and renal tissue samples were harvested for comparisons. Results. Normal histological morphology was determined with Masson trichrome staining and periodic acid-Schiff staining in the control group. Atrophic glomerular structures, vacuolated tubule cells, and degeneration were detected in the renal samples of the study group with Masson trichrome staining. Additionally, flattening was observed on the brush borders of the proximal tubules, and tubular dilatation was visualized with periodic acid-Schiff staining. The histopathologic disruption of renal morphology was verified with detection of significantly elevated kidney function laboratory biomarkers in the study group. Conclusions. Our findings suggests that HBO has adverse effects on renal glomerulus and proximal tubules. However, the functional effects of this alteration should be investigated with further studies.Öğe Elektif cerrahi planlanan kadın hastalarda sezaryen ve diğer elektif cerrahiler arasında preoperatif anksiyete karşılaştırılması(İstanbul Aydın Üniversitesi, 2022) Elmastaş, Deniz; Kuyumcu, MahirAmaç: Bu çalışmada, elektif sezaryen ve diğer cerrahilerin preoperatif anksiyete açısından karşılaştırılması amaçlanmıştır. Gereç ve Yöntemler: Bu prospektif kesitsel çalışmaya 6 aylık dönem içinde (Ocak 2015-Haziran 2015 arası) hastanemiz anestezi polikliniğine başvuran elektif cerrahi nedeniyle operasyona alınacak 180 kadın hasta dâhil edilmiştir. Hastaların preoperatif anksiyete düzeylerini ve bilgi edinme isteklerini ölçmek için Amsterdam Preoperative Anxiety and Information Scale (APAIS) testi kullanıldı. Hastalar sezaryen ve diğer elektif cerrahilere alınanlar olarak iki gruba ayrılıp karşılaştırıldı. Bulgular: Hastaların çoğunluğu (%61,1) 31-49 yaş aralığında idi. Eğitim düzeyi yüksek olan hastaların preoperatif anksiyete düzeyinin eğitim düzeyi düşük olanlara göre istatistiksel anlamlı olarak daha fazla olduğu saptandı (p=0.03). Ayrıca sezaryen operasyonuna alınan hastalarda diğer nedenlerle opere edilecek hastalardan daha fazla preoperatif anksiyetenin görüldüğü ve bu farkın istatistiksel olarak anlamlı olduğu saptandı (p=0.009). Yaş, medeni durum, çocuk sayısı, anestezi öyküsü ve ASA ile preoperatif anksiyete arasında istatistiksel olarak anlamlı bir ilişki saptanmadı (p>0.05). Sonuç: Sezaryen operasyonunda diğer operasyonlara göre daha yüksek anksiyete skorları bulunmuş olup bu durum doğacak olan bebeğe ve annelik fizyolojisinin çok değişken olmasına bağlandı. Ayrıca operasyondan bağımsız olarak yüksek eğitim seviyesinin bilgi edinme isteğinde ve anksiyete düzeyinde anlamlı bir artışa neden olduğu tespit edildi. Sezaryen operasyonuna alınan hastalarda preoperatif anksiyete düzeylerinin uygun yöntemlerle tedavi edilmesinin intraoperatif ve postoperatif sonuçları iyileştirebileceğini düşünmekteyiz.Öğe Kaudal epidural steroid enjeksiyonu sonrası gelişen nadir bir komplikasyon: inatçı hıçkırık(Dicle Üniversitesi Tıp Fakültesi, 2016) Kaydu, Ayhan; Gökçek, Erhan; Kaçar, Cem Kıvılcım; Kuyumcu, MahirLomber kaudal epidural steroid enjeksiyonu(LKESE) bel ağrılarının cerrahi dışı tedavi yöntemlerinden birisidir. Bu olgu sunumunda; kronik bel ağrısı nedeniyle yapılan LKESE sonrası nadiren gelişen bir inatçı hıçkırık olgusunun sunumunu ve tedavisini anlatmaya çalıştık.Öğe A Miracle That Accelerates Operating Room Functionality: Sugammadex(Hindawi Ltd, 2014) Dogan, Erdal; Akdemir, Mehmet Salim; Guzel, Abdulmenap; Yildirim, Mehmet Besir; Yildirim, Zeynep Baysal; Kuyumcu, Mahir; Gumus, AbdurrahmanBackground. Sugammadex offers a good alternative to the conventional decurarisation process currently performed with cholinesterase inhibitors. Sugammadex, which was developed specifically for the aminosteroid-structured rocuronium and vecuronium neuromuscular blockers, is a modified cyclodextrin made up of 8 glucose monomers arranged in a cylindrical shape. Methods. In this study, the goal was to investigate the efficacy of sugammadex. Sugammadex was used when there was insufficient decurarisation following neostigmine. This study was performed on 14 patients who experienced insufficient decurarisation (TOF < 0.9) with neostigmine after general anaesthesia in the operating rooms of a university and a state hospital between June, 2012, and January, 2014. A dose of 2 mg/kg of sugammadex was administered. Results. Time elapsed until sugammadex administration following neostigmine 37 +/- 6 min, following sugammadex it took 2.1 +/- 0.9 min to reach TOF >= 0.9, and the extubation time was 3.2 +/- 1.4 min. No statistically significant differences were detected in the hemodynamic parameters before and after sugammadex application. From the time of administration of sugammadex to the second postoperative hour, no side effects or complications occurred. None of the patients experienced acute respiratory failure or residual block during this time period. Conclusion. Sugammadex was successfully used to reverse rocuronium-induced neuromuscular block in patients where neostigmine was insufficient.Öğe Socio-demographic and clinical factors related to mortality among the geriatric suicide attempters admitted to the emergency department(Dicle Üniversitesi Tıp Fakültesi, 2015) Zengin, Yılmaz; Gündüz, Ercan; İçer, Mustafa; Dursun, Recep; Durgun, Hasan Mansur; Gürbüz, Hüseyin; Demir, Süleyman; Kuyumcu, MahirObjective: The ratio of elderly people in Turkey is rapidly growing. Accordingly, psychiatric problems and suicidality among elderly people are growing concerns. In this study, we aimed to investigate the socio-demographic characteristics of older people who attempted suicide by drug and to identify risk factors affecting mortality. Methods: Patients who were over 65 years old and admitted to the emergency department of a university hospital due to drug-related suicide attempt between January 1, 2004 and December 30, 2014, were included into this retrospective cross-sectional study. Relationship between suicide attempt and mortality was investigated in regard to socio-demographic and clinical factors. Patients were divided into two groups according to whether they survived or died. Results: Of the 107 patients included in the study, 68.2% were female and 31.8% were male; 34 6% were married. Common reasons for suicide attempt were depression (34.6%) and domestic violence (30.8%). Analgesics (33.6%) were the most common drugs used in suicide attempts. The analysis of the factors related to suicide attempt and mortality revealed that significant factors were loneliness, being widowed, being retired, having adjustment disorder and anxiety disorder. Conclusion: Loneliness, being widowed, being retired, adjustment disorder, and anxiety disorder were found as the risk factors affecting mortality in geriatric suicide attempts.Öğe Tek akciğer ventilasyonun kognitif fonksiyonlar üzerine etkisi: Kesitsel araştırma(Turkiye Klinikleri, 2023) Aydoğan, Mesut; Çelik, Enes; Yıldırım, Zeynep Baysal; Kuyumcu, MahirObjective: Postoperative cognitive dysfunction (POCD) is frequently seen in patients of all age groups, especially advanced age, after major surgery and may persist for months. Although its etiology is multifactorial, factors affecting the balance of cerebral oxygen delivery and consumption are blamed. For this reason, it was aimed to evaluate whether patients developed POCD by evaluating POCD with mini-mental state test in thoracic surgery patients who underwent one lung ventilation (OLV), which can progress with serious complications such as hypoxia. Material and Methods: Patients between 20 years and 72 years of age candidates for OLV in thoracic surgery were included in the study. The anesthesia protocol was applied the same way in all patients. Cognitive assessment was conducted 1 day before the operation, 1 day after the operation and 3 days after. For this purpose, Mini-Mental Status Examination test was used. Results: Thirty patients were included in the study. POCD was detected in 26% of patients who underwent OLV. The mini-mental state test of the patients showed a difference in terms of cognitive dysfunction between preoperative and postoperative day 1 and day 3. However, no difference was detected between day 1 and day 3 after surgery. Conclusion: Early cognitive dysfunction is observed in patients undergoing OLV in thoracic surgery. Surgical time, anesthetic drugs, and patient-related parameters are effective, and patients should be closely monitored in terms of cognitive functions of the patients, in close follow-up and after surgery.Öğe Transcatheter Closure of Patent Ductus Arteriosus in Children with the Occlutech Duct Occluder(Springer, 2017) Bilici, Meki; Demir, Fikri; Akin, Alper; Ture, Mehmet; Balik, Hasan; Kuyumcu, MahirThe aim of this study was to evaluate the feasibility, efficacy and safety of transcatheter closure of patent ductus arteriosus (PDA) with the Occlutech duct occluder (ODO) in children. We reviewed the clinical records of 71 patients who underwent percutaneous closure of PDA with an ODO between September 2014 and August 2016. The Occlutech duct occluder was applied to 71 patients during the study period (September 2014-August 2016), and the results were analyzed in this study. Forty-two of the patients were female and 29 male. The median age was 20.5 months (range, 6-194 months) and median weight was 16 kg (range, 6-68 kg). The PDA was classified as type A in 54 patients (76.1%), type E in 14 (19.7%), type C in 2 (2.8%) and type B in 1 (1.4%) based on the Krichenko classification. A standard ODO device was used for the transcatheter closure procedure in 66 patients and the long-shank ODO device in 5. In the echocardiographic measurement of PDA, the median smallest diameter was 2.7 mm (range, 1.5-7.0 mm), and in the angiographic measurement, the median smallest diameter was 2.5 mm (range, 1.5-6.5 mm). All 71 patients underwent successful PDA closure with the ODO. Angiography following the procedure showed complete closure in 47 patients (66.2%), mild residual shunt in 13 patients (18.3%) and a trivial shunt in 11 patients (15.5%). Color flow Doppler echocardiogpaphy at 24 h post-implantation showed that complete closure was achieved in 65 patients (91.5%), and 6 patients (8.5%) had mild residual shunt. All patients (100%) had complete closure at 30 days of follow-up. The results of this study showed that the Occlutech PDA occluder device is safe and effective in the closure of PDA. As the pulmonary artery side of the device is wider than the aortic side, protrusion toward the aortic side and embolization are prevented, but there is residual shunt in the early period, although this residual shunt disappeared after a few months.Öğe Unexpected complication of oesophagoscopy: iatrogenic aortic injury in a child(Clinics Cardive Publ Pty Ltd, 2016) Tezcan, Orhan; Oruc, Menduh; Kuyumcu, Mahir; Demirtas, Sinan; Yavuz, Celal; Karahan, OguzIntroduction: Oesophagoscopy is usually a safe procedure to localise and remove ingested foreign bodies, however, unexpected complications may develop during this procedure. In this case report we discuss iatrogenic aortic injury, which developed during oesophagoscopy, and its immediate treatment. Case report: A six-year-old male patient was admitted to hospital with symptoms of having ingested a foreign body. Oesophagoscopy was carried out and the foreign body was visualised at the second constriction of the oesophagus. During this procedure, profuse bleeding occurred. Subsequently, a balloon dilator was placed to control bleeding in the oesophagus. Thoracic contrast tomography revealed thoracic aortic injury. Open surgical aortic repair was immediately carried out on the patient and the oesophageal hole was primarily repaired. The patient was discharged on postoperative day 15 with a total cure. Conclusion: Although oesophagoscopy is a safe, easily applied method, it should be kept in mind that fatal complications may occur during the procedure. This procedure should be done in high-level medical centres, which have extra facilities for managing complications.Öğe Which COVID-19 patients die in intensive care unit (ICU) in Turkey(Dicle Üniversitesi Tıp Fakültesi, 2022) Dursun, Recep; Mermutluoğlu, Çiğdem; Aktar, Fesih; Tekin, Recep; Kuyumcu, Mahir; Yıldız, İsmail; Kadiroğlu, Ali Kemal; Türe, Mehmet; Erbaş, Erkan; Çelen, Mustafa KemalObjective: The World Health Organization labelled the COVID-19 outbreak a pandemic on March 11, 2020, the first day COVID-19 cases were diagnosed in Turkey. Since then, people's main concerns have been whether their lives or the lives of their relatives would be at risk if they became infected. The objective of this study was to determine the risk factors that increase mortality in COVID-19 patients treated in ICUs and to facilitate the appropriate precautions. Methods: In this study, patients who were diagnosed with COVID-19 [positive on a polymerase chain reaction (PCR) test] and monitored in the Pandemic Hospital at Diyarbakır Dicle University between 15 March 15 and 15 May, 2020, were evaluated for risk factors for mortality. Results: A total of 50 ICU patients were included in the study. Of them, 52% were males, and the mean age was 63.8±17.6 years. A comparison of deceased and surviving patients showed that being female, older than 62, and a smoker and having diabetes mellitus, hypertension, and/or coronary artery disease significantly increased mortality. An investigation of the findings from the patients' lung tomography examinations revealed that relatively prominent pulmonary involvement and localization did not affect mortality. Conclusions: Because patients who are advanced in age, female and smokers and have comorbidities are in the high-risk group, measurements related to treating the COVID-19 disease should be improved. Laboratory parameters are useful for the evaluation of mortality and morbidity, while mechanical ventilation increased mortality.
