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    Management of anesthesia in pregnant women with pulmonary hypertension
    (Verduci Publisher, 2023) Soner, H. Tosun; Bulut, E.; Uzundere, O.; Soner, S.; Yildirim, Z. Baysal; Kuyumcu, M.
    OBJECTIVE: Pulmonary hypertension (PH) is a rare heart disease associated with high maternal and fetal mortality. This study aims to discuss anesthesia management and the fetal and maternal outcomes of patients with PH followed-up at our clinic. PATIENTS AND METHODS: This study includes a retrospective analysis of 105 pregnant women with PH. The patients were classified according to the mean pulmonary artery pressure (mPAP) values measured at rest by transthoracic echocardiography. The first group included patients with an mPAP value between 25 and 49 mmHg, considered to have a mild PH, whereas patients with an mPAB value >= 50 mmHg were considered to have severe PH and were included in the second group. RESULTS: When the patients were examined for etiology, the majority (n=84, 70.5%) were found to have type 2 PH. It was found that in pregnant women with severe PH, the diameters of the left atrium, right atrium, and right ventricle were significantly larger (p=0.008, p=0.04, and p=0.013, respectively), and the ejection fraction was also significantly lower (p=0.04). CONCLUSIONS: Although there has been a partial decrease in mortality for PH in recent years, it is still a serious condition that requires a multidisciplinary approach and well -planned obstetric treatment.
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    Protective Effects of Carvacrol Against Methotrexate-induced Liver Toxicity in Rats
    (Acta Medical Belgica, 2014) Bozkurt, M.; Bodakci, M. N.; Turkcu, G.; Kuyumcu, M.; Akkurt, M.; Sula, B.; Em, S.
    Background : To investigate whether carvacrol (CAR) pretreatment reduces the severity of methotrexate (MTX)-induced hepatotoxicity in rats. Methods : A total of 24 rats were equally divided into three groups : group I, control; group II, MTX-treated; and group III, CAR+MTX-treated. On Day 1 group III received a one-time intraperitoneal dose of CAR (73 mg/kg), and on Day 2 both groups II and III received a single dose of intraperitoneal MTX (20 mg/kg). The rats were then sacrificed so to harvest blood and liver tissue samples to determine malondialdehyde (MDA), total antioxidant capacity (TAS), total oxidant status (TOS), alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphata.se (ALP) levels. Histological specimens were examined via light microscopy. Results : Levels of MDA, ALT, AST and ALP in rat liver tissue samples were significantly higher in the MTX-treated group relative to the control group. However, TAS was significantly reduced in the MTX-treated group when compared to controls. Pretreating rats with CAR counteracted the effect of MTX exposure as MDA was significantly decreased and TAS was elevated in liver tissues when contrasted with the MTX-treated group. Furthermore, histological examination demonstrated significant liver injury in the MTX-treated group versus the CAR+MTX group. Conclusions : Pretreatment with CAR markedly diminished liver damage induced by MTX. Therefore, CAR administration preceding MTX treatment might be a promising therapeutic modality to prevent and/or lessen the extent of MTX-induced hepatotoxicity.