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    Öğe
    A cross-sectional measurement of endogenous oxidative stress marker levels in obsessive compulsive disorder
    (Aves Yayıncılık, 2022) Kuruhan, Faruk; Kamış, Gülsüm Zuhal; Alp, Hamit Hakan; Çim, Emine Füsun Akyüz; Atlı, Abdullah
    Background: There is a correlation between the increase in reactive oxygen radicals and the presence of specific mental illnesses. In this context, the objective of this study is to investigate the relationship between obsessive-compulsive disorder and the variations in the levels of several endogenous oxidative stress markers. Methods: Thirty obsessive-compulsive disorder patients were included in the study as the patient group, and 30 healthy volunteers of matching demographic characteristics were included in the study as the control group. Accordingly, the patient group consisted of 10 females and 20 males with a mean age of 29.5 ± 6.1 years, and the control group consisted of 15 females and 15 males with a mean age of 31.9±5.6 years. The serum nicotinamide adenine dinucleotide phosphate oxidase-2, nicotinamide adenine dinucleotide phosphate oxidase-4, and malondialdehyde levels of the 2 groups were compared using the independent samples t-test. The relationships between the serum nicotinamide adenine dinucleotide phosphate oxidase-2, nicotinamide adenine dinucleotide phosphate oxidase-4, and malondialdehyde levels of the 2 groups were analyzed using the Pearson’s correlation coefficient. Results: The serum nicotinamide adenine dinucleotide phosphate oxidase-2, nicotinamide adenine dinucleotide phosphate oxidase-4, and malondialdehyde levels of the patient group were statistically significantly higher than those of the control group (P < .001). Statistically significant positive correlations were detected between the serum nicotinamide adenine dinucleotide phosphate oxidase-2 and nicotinamide adenine dinucleotide phosphate oxidase-4 levels (r=0.692, P=.001) and between the serum nicotinamide adenine dinucleotide phosphate oxidase-2 and malondialdehyde levels (r=0.563, P=.001). Conclusion: The results of this study indicated that oxidative stress and lipid peroxidation levels were higher in obsessive-compulsive disorder patients. Based on this finding, NOX-2 and NOX-4 levels can be used as indicators of endogenous oxidative stress in obsessive-compulsive disorder patients.
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    Öğe
    Effect of Obsessive Compulsive Disorder on Word StemCompletion Test (WSCT) and Cognitive Processes
    (2020) Aydın, Adem; Atlı, Abdullah; Kuruhan, Faruk; Çim, Emine Füsun Akyüz
    Aim: The aim of this study is to evaluate the relationship between implicit memory performance and cognitive processes in individuals with Obsessive-Compulsive Disorder (OCD).Material and Method: In this study, we aimed to investigate the relationship between implicit memory performance and cognitive processes by comparing a group of 30 Obsessive-Compulsive Disorder (OCD) patients that presented to Yüzüncü Yıl University Medical School Hospital Psychiatry Polyclinic and a group of 40 healthy subjects. Both groups were administered demographic data form and the Word Stem Completion Test (WSCT). The patient group was additionally administered Yale-Brown Obsessive Compulsive Scale (Y-BOCS), Dimensional Yale-Brown ObsessiveCompulsive Scale (DY-BOCS), Metacognitions Questionnaire 30 (MCQ-30), Thought-Action Fusion Scale (TAFS), and Obsessive Beliefs Questionnaire-44 (OBQ-44).Results: It was determined that the increase in Y-BOCS and cognitive parameters (TAFS, OBQ-44, MCQ-30) scores adversely affected the performance of WSCT. The mean WSCT score was 7.63±3.05 in the patient group and 6.30±2.09 in the control group (p=0.034). TAF parameter is the most important cognitive parameter affecting implicit memory performance.Conclusion: In OCD, implicit memory performance is adversely affected as the severity of the disease increases.