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Öğe COMBINED TREATMENT OF A LARGE AGGRESSIVE CENTRAL GIANT CELL GRANULOMA (CASE REPORT)(Cumhuriyet University Faculty of Dentistry, 2017) Koparal M.; Alan H.; Ağaçayak K.S.; Erdoğdu I.H.; Gulsun B.Central giant cell tumours are rare, accounting for less than 7% of all jaw tumours. These tumours are usuallyobserved in women, occur most often in the mandible,and are more common in the second decade of life.Treatment consists of local removal, partial resection, ortotal resection. In this case, a 32-year-old female patientpresented in our clinic with pain in the anterior mandible.No cervical lymphadenopathy was detected uponphysical examination. No ulceration was observed duringthe intraoral examination, but sensitivity was found in thevestibular area. However, no sensation loss in any teethor in the lips was detected. This case report presents a 32-year-old female patient with central giant cell tumourcausing extensive bone loss in the mandible base that wastreated with partial resection © 2017. Cumhuriyet Dental Journal. All Rights Reserved.Öğe Effect of zoledronic acid application on different graft materials in calvarial bone defect models: An experimental analysis(Science Printers and Publishers Inc., 2016) Koparal M.; Gülsün B.; Deveci E.; Agacayak K.S.; Hamidi A.OBJECTIVE: To determine the effect of zoledronic acid on graft materials in bone calvarial defects. STUDY DESIGN: Eighty adult (12 weeks) Sprague-Dawley male rats weighing from 300-350 g were divided into groups: calvarial defect, calvarial defect+synthetic graft, and calvarial defect+xenograft. All groups received zoledronate intravenously for a week after surgery and were sacrificed at either 6 or 12 weeks after their operation. The rat calvariae were fixed in 10% neutral buffered formalin before decalcification in 10% ethylenediaminetetraacetic acid for 20 days. Calvarial bone samples were then dehydrated and processed for embedding in paraffin wax. Sections 5 ?m thick were stained with hematoxylin and eosin and examined by light microscopy. RESULTS: The effects of zoledronic acid, a third-generation nitrogen-containing bisphosphonate, on different graft materials in rats with critical-size calvarial defects were analyzed and compared. Significantly less graft resorption was identified in zoledronic acid-treated rats that had received a xenograft than in either the untreated rats or those with a synthetic graft. In the xenograft group primary ossification was visible at week 12, and the graft had entered the bone to a greater extent than in the other experimental groups or in the control group. Osseous structures were also observed more clearly in this group than in the others. CONCLUSION: Zoledronic acid histopathologic bone graft stimulates bone formation. Zoledronic acid may be considered among the therapeutic methods available to improve the bone formation process in calvarial bone formation. © Science Printers and Publishers, Inc.Öğe Effects of manganese ethylene-bis-dithiocarbamate (Maneb) on rat nasal respiratory mucosa(Acta Medica Mediterranea, 2013) Deveci E.; Yorgancilar E.; Ekinci C.; Koparal M.; Akkus Z.; Yavuz D.Maneb (Mn-ethylene(bis)dithiocarbamate is a dithiocarbamate pesticides. It is a fungicide pesticide used in the control of mildew disease on certain crops. In general, dithiocarbamates are considered chemicals of low toxicity for humans. However, the effects of maneb in humans are diverse. It has some effects to humans via absorption through skin and respiratory system. The nasal mucosa is the first part of the airways in contact with the environment and toxic agents. The aim of this study was todetermine the histopathological effects of maneb on nasal mucosa. In experimental group, the maneb was administered with inhalation to 10 male Wistar-Albino rats for five days a week. The control group (n=10) received distilled water with spray at the same time period. The experiment was terminated after three weeks. In each case, sections of the nosewere taken. In experimental group,microscopic examination of nasal respiratory mucosa revealed; Hypertrophy of epithelial cells and goblet cells, increasing of mucus secretion, decreasing in sizes of cilia and flattening of the cells near the basement membrane and apoptotic cells in the degenerated respiratory epithelial cells, detected a mild inflammatory reaction and a vascular dilatation in the connective tissue. All changes were statistically significant. In control group of 10 rats no significant histopathologic lesions were found. As a result, our study , maneb is potentially toxic agent to respiratory mucosa.Öğe Sedation during implant surgery(University of Dicle, 2015) Koparal M.; Alan H.; Gulsun B.; Celik F.Medical dentistry treatments take the form of practical applications rather than the use of medical therapies. Performing procedures under local anaesthesia can inhibit pain in patients but does not prevent fear and the physiological reactions that occur in response to it. This may affect the success of treatment. The use of implant surgery, one of the practical applications of medical dentistry, has been increasing gradually over the last 20 years. In order to perform surgery comfortably and prevent fear in patients during the procedure, sedation is established. In this article, we present the sedative agents administered during implant surgery and their usage.
