Yazar "Komek, H." seçeneğine göre listele
Listeleniyor 1 - 13 / 13
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe Breast cancer in a male patient with type 1 neurofibromatosis Tip 1 nörofibromatozisli erkek hastada meme kanseri(2014) Atasoy, A.; Komek, H.; Akgül, N. Babacan; Fırat, U.; Cihan, S.Tip 1 nörofibromatozis (NF1) aynı zamanda von Recklinghausen olarak da bilinen nörokutanöz bir hastalıktır. Otozomal dominant geçiş göstermekte olup insidansı 1/2500 ve prevelansı 1/4000 olarak tanımlanmıştır. NF1 hastalarında malign ve benign sinir sistemi tümörleri sık görülür. Meme kanseri NF1 hastalarında nadir görülür.NF1'li erkek hastalarda meme kanseri gelişimi ile ilgili birkaç yayın mevcuttur. Bu makalede meme kanseri gelişen 58 yaşında NF1'li erkek hastayı sunmak istedik. Hasta sağ memede ağrısız bir kitle ve sırt ağrısı ile başvurdu. Tanısal tetkiklerde karaciğer ve multipl kemik metastazları ile sağ memede karsinomu düşündüren kitle tespit edildi. Memedeki kitlenin patolojik değerlendirmesinde invaziv ductal karsinoma tespit edildi. Üç haftada bir 6 kür CAF (siklofosfamid, doxorubicin, 5-fluorourasil) ve kemiklere palyatif radyoterapi uygulandı. NF1'li erkek hastalarda meme kanseri ile ilgili yayınlar sınırlıdır. NF1'li bütün hastalarda memede gelişen her yeni kitle dikkatlice değerlendirilmeli ve gerektiğinde mamografi, meme ultrason ve meme manyetik rezonans görüntülemesi gibi ileri tetkikler yapılmalıdır.Öğe Combination of [68Ga]Ga-PSMA PET/CT and [18F]FDG PET/CT in demonstrating dedifferentiation in castration-resistant prostate cancer(Elsevier France-Editions Scientifiques Medicales Elsevier, 2023) Kepenek, F.; Can, C.; Komek, H.; Kaplan, I; Gundogan, C.; Ebinc, S.; Guzel, Y.Aim of the study. - In this study, we aimed to determine the factors affecting increased glucose metabolism, which is one of the dedifferentiation mechanisms, by using [18F]FDG and [68Ga]Ga-PSMA PET/CT in patients with castration-resistant prostate cancer (CRPC).Materials and method. - Ninety-three patients with CRPC were included in the study. Gleason score (GS), and total PSA and free PSA levels of the patients were recorded. Patient-and organ-based evaluations were performed according to the lesion uptakes as follows: score 0: PSMA (-) FDG (-), score 1: PSMA (+) FDG (-), score 2: PSMA (+) FDG (+) (FDG < PSMA), score 3: PSMA (+) FDG (+) (FDG = PSMA), score 4: PSMA (+) FDG (+) (FDG > PSMA), and score 5: PSMA (-) FDG (+). scores 1 and 2 were classified as group 1, and scores 3 to 5 were classified as group 2.Results. - The median age of our patients was 70 (51-88) years. Eighty-eight patients (94.6%) were PSMA-positive, 78 patients (83.8%) were FDG-positive, and 89 patients (95.6%) were or PSMA or FDG positive. When the two groups were compared in terms of patient-based parameters, the median age and GS were found to be significantly higher in group 2. ROC analyses revealed that age and GS were significant in predicting group 2.Conclusion. - Since glucose metabolism can increase in CRPC patients with advanced age and high GS, we recommend combining [18F]FDG PET/CT with [68Ga]Ga-PSMA PET/CT in routine clinical practice in order to identify this patient subset and refer them to additional therapies. ?@ 2023 Published by Elsevier Masson SAS.Öğe Comparing the results of PET/CT, CT and Tc-99m Aerosol scintigraphy in malign pleural mesothelioma and asbestozis(Springer, 2011) Aguloglu, N.; Kaya, H.; Komek, H.; Kaplan, M.; Bogatekin, G.[Abstract Not Available]Öğe A comparison of oral glucose and GIK infusion with F18 FDG PET study in evaluation of myocardial viability(Springer, 2010) Kaya, H.; Balci, T. Ansal; Komek, H.; Bellur, B. Kizilkan; Bellur, G.[Abstract Not Available]Öğe Diagnostic value of PET/CT in differentiating benign from malignant solitary pulmonary nodules(Imprimatur Publications, 2013) Dalli, A.; Sen, H. Selimoglu; Coskunsel, M.; Komek, H.; Abakay, O.; Sergi, C.; Tanrikulu, A. CetinPurpose: Solitary pulmonary nodules (SPNs) are round or oval lesions with a clear border with the surrounding parenchymal tissue and a radiologic diameter smaller than 3 cm which are not associated with atelectasis, pneumonia, lymphadenopathy, or chest wall pathologies. The purpose of the present study was to evaluate the efficacy of positron emission tomography (PET) / computerized tomography (CT) in differentiating benign from malignant SPNs. Methods: In this retrospective study, 209 patients, who were diagnosed with SPN by thoracic CT and demonstrated positive or negative results for malignancy in the PET/CT examination between January 2007 and June 2010, were enrolled. Among the 91 patients who gave consent for interventional procedures, performed were bronchoscopic endobronchial biopsy in 10, transbronchial biopsy in 15, bronchoscopic brushing in 4, transthoracic needle biopsy in 11, video-assisted thoracoscopy (VATS) in 4, lobectomy in 22, pneumonectomy in 2, and wedge resection in 23. The materials were histo pathologically examined. Results: 129 (61.72%) of the SPN cases were benign and 80 (38.27%) malignant. The mean SUVmax value for the benign SPNs was 2.06 +/- 3.29 and 7.39 +/- 5.69 for the malignant SPNs (p=0.000). Positive correlation was found between the nodule diameter and risk for malignancy. A SUVmax value of 4 was found to have the best sensitivity and specificity. Conclusion: PET/CT was shown to be an accurate method in the differential diagnosis of benign from malignant solitary pulmonary nodules.Öğe The Effect on Survival and Mortality of the Highest SUVmax Value on Metastatic Foci in Postoperative Kidney Tumors(Wolters Kluwer Medknow Publications, 2018) Komek, H.; Altindag, S.; Can, C.; Aguloglu, N.; Morcali, H.; Kepenek, F.; Karaoglan, H.Objective: One-third of patients newly diagnosed with a kidney tumor have metachoronous disease, 25-50% have synchronous metastasis, and approximately 30-40% of patients have metastasis at the time of diagnosis. Metastasis mostly occurs in the lungs, regional lymph nodes, bones, and liver. The present study was aimed to determine the effect on mortality the values of standard uptake value (SUV)max measured with positron emission tomography (PET) in metastases of kidney tumors. Material and Methods: A retrospective review was conducted of the files of 77 patients newly diagnosed with kidney tumor and disease staging determined with PET in the Nuclear medicine Department of Saglik Bilimleri University Diyarbakir Gazi Yasargil Training and Research Hospital between August 2007 and April 2012. The gender, age, histological types, metastases, SUVmax values, and dates of death of the patients were recorded in the SPSS software. Results: It was observed that higher SUVmax values indicated a shorter survival time (r = .303) (P = 0.022). Patients with metastasis lived for a shorter period (P < 0.001), particularly those with liver metastasis (r = .515) (P = 0.049). Metastases were most frequently seen in lymph nodes (42.1%); the SUVmax values of lung metastases were higher (P = 0.025) and papillary carcinomas showed higher SUVmax uptake (P = 0.015). Conclusions: In the present study, it was concluded that the higher the SUVmax value the shorter the survival time. The survival time of patients with metastasis was shorter, and this could be estimated through the measured SUVmax values.Öğe An Index Proposal for the Evaluation of Myocardial Viability(Springer, 2011) Kaya, H.; Balci, T. A.; Komek, H.; Bellur, B. Kizilkan[Abstract Not Available]Öğe Prognostic value of fluorine-18 fluorodeoxyglucose positron emission tomography in patients with advanced non-small cell lung cancer: Single center experience(Imprimatur Publications, 2012) Inal, A.; Kucukoner, M.; Kaplan, M. A.; Urakci, Z.; Karakus, A.; Komek, H.; Dostbil, Z.Purpose: The purpose of this retrospective single-center study was to evaluate the prognostic implication on overall survival (OS) of the F-18 FDG PET scan in locally advanced or metastatic non small cell lung cancer (NSCLC) patients. Methods: We retrospectively reviewed 120 locally advanced or metastatic NSCLC patients (December 2004-November 2011) treated/followed at the Dicle University, School of Medicine, Department of Medical Oncology. SUVmax and other potential prognostic variables (n=18) were chosen for analysis. Univariate and multivariate analyses were conducted to identify prognostic factors for OS. Results: Among 18 variables of univariate analysis, 6 were identified to bear prognostic significance: sex (p=0.01), performance status (PS) (p=0.03), stage (p=0.04), bone metastases (p=0.002), serum albumin (p=0.01) and blood glucose level (p=0.03). Multivariate analysis showed that PS, bone metastases and serum albumin level were independent prognostic factors for OS (p=0.01, p=0.004, p=0.003, respectively). Conclusion: PS, serum albumin levels and bone metastases were independent prognostic factors, while FDG uptake of the primary lesion was not associated with prognosis of OS in locally advanced or metastatic NSCLC patients.Öğe Relationship between 18 FDG PET-CT findings and the survival of 177 patients with malignant pleural mesothelioma(Verduci Publisher, 2013) Abakay, A.; Komek, H.; Abakay, O.; Palanci, Y.; Ekici, F.; Tekbas, G.; Tanrikulu, A. C.BACKGROUND AND OBJECTIVES: Malignant pleural mesothelioma (MPM) is a fatal malignancy. Radiological imaging is necessary for the diagnosis, staging, and clinical management of patients with MPM. The 18 fluorodeoxyglucose positron emission tomography (18 FDG-PET) scan has proven useful in preoperative staging and as a prognostic tool in MPM. We aimed to investigate the relationship between the pre-treatment 18 FDG PET/CT results, together with other known clinical parameters, and the survival of patients with MPM in our region. PATIENTS AND METHODS: A retrospective analysis was performed on the data of 177 patients with MPM between April 2007 and April 2011. Pretreatment 18 FDG PET/CT scans were done on all patients. Survival time was calculated by the Kaplan-Meier method. RESULTS: The mean age was 55.40 years. There were 56% male patients and 44% female patients. The mean survival time was 11 months from time of diagnosis. According to multivariate analysis results, being of male gender increased the poor prognosis 5.30 times, a Karnofsky performance score (KPS) < 60 increased a poor prognosis 2.18 times, being on best supportive care increased a poor prognosis 25.40 times, the stage III-IV increased a poor prognosis 11.13 times, and a level of maximum standardized uptake value (SUVmax) > 5 increased a poor prognosis 4.34 times. CONCLUSIONS: MPM remains a fatal prognosis. Significant predictors of survival include KPS, stage of disease, gender, treatment regimen and level of SUVmax. An understanding of the importance of these markers for MPM prognosis should allow targeted treatments to be developed.Öğe The Relationship Between Lymph Node Staging and Tumor SUVmax in NSCLC(Springer, 2012) Balcil, T. A.; Komek, H.; Cengiz, M.; Kaya, H.[Abstract Not Available]Öğe The Relationship between Staging and SUVmax in Non-Small Cell Lung Cancer(Springer, 2015) Kaya, H.; Balci, T.; Komek, H.; Cengiz, M.[Abstract Not Available]Öğe The role of PET\CT in cancer patients with unknown primary and brain metastasis(Springer, 2011) Balci, T. A.; Koc, Z. P.; Komek, H.; Kaya, H.; Guzel, Y.[Abstract Not Available]Öğe A Secondary F-18 FDG PET\CT Finding of Infection: Increased Spleen Activity(Springer, 2009) Balci, T. A.; Komek, H.; Koc, Z. P.; Kaya, H.[Abstract Not Available]
