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    Biochemical and Histopathological Investigation of Resveratrol, Gliclazide, and Losartan Protective Effects on Renal Damage in a Diabetic Rat Model
    (Sci Printers & Publ Inc, 2015) Ezel, Tasdemir; Kocyigit, Yuksel; Deveci, Engin; Atamer, Yildiz; Sermet, Abdurrahman; Uysal, Ersin; Aktas, Ayfer
    [Abstract Not Available]
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    The effect of dietary supplementation of Nigella sativa L. on serum lipid profile in rats
    (Saudi Med J, 2009) Kocyigit, Yuksel; Atamer, Yildiz; Uysal, Ersin
    Objectives: To investigate the effect of oral treatment of Wistar albino rats with different doses of Nigella sativa L. (NS) powdered seeds on the levels of serum lipids. Methods: This study was performed in the Medical Science Application and Research Center of Dicle University, Diyarbakir, Turkey, from February 2003 to December 2008. A total of 75 Wistar albino male rats, 60 of them with NS supplementation and 15 animals acting as controls, were included in the study. The NS groups were divided into 4 main groups of 15 each. Four doses of NS were used (100, 200, 400, and 600mg/kg/day). Each dose group was further divided into 3 duration subgroups of 5 rats each, the feeding of NS seeds continued for one, 2, and 4 weeks. Control animals were divided into 3 main groups of 5 rats each. The rats were sacrificed at one, 2, and 4 weeks after feeding. Lipid parameters were measured. Results: Rats treated with the 400mg dose for one week's duration showed a significant increase in high-density lipoprotein-cholesterol levels. There was a significant decrease in low density lipoprotein-cholesterol levels after one week for 400 and 600mg doses, and all doses after 2 weeks and 4 weeks for 200 and 600mg doses when compared to control groups. There was a significant decrease in very low-density lipoprotein-cholesterol levels after one week for 200, 400, and 600mg doses, and all doses for 2 and 4 weeks. A 400mg dose for 2 weeks, and all doses for 4 weeks caused a significant decrease in triglyceride levels. There was a significant decrease of total cholesterol levels in all doses after 4 weeks of NS feeding. Conclusion: These results indicate that NS may a-meliorate the alteration in the lipid levels caused by diseases or toxic agents.
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    Effect of nigella (Nigella sativa L.) seeds on hematological parameters in rats
    (Saudi Med J, 2009) Kocyigit, Yuksel; Atamer, Yidiz; Uysal, Ersin; Baran, Murat-Sedat
    [Abstract Not Available]
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    Effect of oxidative stress on antioxidant enzyme activities, homocysteine and lipoproteins in chronic kidney disease
    (Springer Heidelberg, 2008) Atamer, Aytac; Kocyigit, Yuksel; Ecder, Sabahat Alisir; Selek, Sahabettin; Ilhan, Nevin; Ecder, Tevfik; Atamer, Yildiz
    Background: Our aim was to determine the association of paraoxonase (PON1), superoxide dismutase (SOD) and catalase (CAT) activities and malondialdehyde (MDA) concentration, with lipoprotein and homocysteine (Hcy) concentrations in chronic kidney disease (CKD). Methods: We examined 60 patients with CKD (35 men and 25 women), aged 52.7 +/- 3.1 years, and 60 age-, sex- and body mass index (BMI)-matched control subjects. Serum PON1 activity, levels of lipoproteins, Hcy and MDA were evaluated; SOD and CAT activities in erythrocytes were also investigated. Results: Levels of MDA, lipoprotein (a) (Lp(a)) and Hcy were significantly higher, while PON1 activity was lower in CKD than in controls (p<0.001). There were no significant differences between the patients and controls in the SOD and CAT activities (p>0.05). Levels of high-density lipoprotein cholesterol (HDL-C) and apolipoprotein A-I (ApoA-I) were lower in CKD than in controls (p<0.001), whereas total cholesterol (T-Chol) and triglyceride (TG) levels showed no significant difference between the groups. Levels of apolipoprotein B (ApoB) and low-density lipoprotein cholesterol (LDL-C) were higher in CKD than in controls (p<0.001). In CKD, PON1 activities were correlated with levels of Hcy, MDA, HDL-C, Lp(a) and ApoA-I. A significant positive correlation was found between levels of Hcy and Lp(a). Conclusions: The results of this work suggest that patients with CKD exhibit an oxidant-antioxidant imbalance which is closely related to high levels of atherosclerotic risk factors.
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    Leptin levels and lipoprotein profiles in patients with cholelithiasis
    (Sage Publications Ltd, 2015) Sarac, Serdar; Atamer, Aytac; Atamer, Yildiz; Can, Ahmet Selcuk; Bilici, Aslan; Tacyildiz, Ibrahim; Kocyigit, Yuksel
    Objective To determine the relationships between serum leptin and levels of lipoprotein(a) [Lp(a)], apolipoprotein A-1 (ApoA-1) and apolipoprotein B (ApoB) in patients with cholelithiasis. Methods Patients with ultrasound-confirmed cholelithiasis and controls frequency-matched for age, sex, body mass index, fasting blood glucose and haemoglobin A(1c) levels were recruited. Fasting blood samples from all study participants were assayed for glucose, haemoglobin A(1c,) total cholesterol, high density lipoprotein-cholesterol (HDL-C) and triglyceride. Serum Lp(a), ApoA-1 and ApoB levels were measured using nephelometric assays; serum leptin was measured using an enzyme-linked immunosorbent assay. Results A total of 90 patients with cholelithiasis and 50 controls were included in the study. Serum levels of leptin, Lp(a), total cholesterol, triglyceride and ApoB were significantly increased, and levels of ApoA-1 and HDL-C were significantly decreased, in patients with cholelithiasis compared with controls. Serum leptin in patients with cholelithiasis were significantly positively correlated with Lp(a) and ApoB and negatively correlated with ApoA-1. Conclusions Patients with cholelithiasis have higher leptin levels and an altered lipoprotein profile compared with controls, with increased leptin levels being associated with increased Lp(a) and ApoB levels, and decreased ApoA-1 levels, in those with cholelithiasis.