Yazar "Kocyigit, Y." seçeneğine göre listele

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    Effects of rosiglitazone on serum paraoxonase activity and metabolic parameters in patients with type 2 diabetes mellitus
    (Assoc Bras Divulg Cientifica, 2013) Atamer, Y.; Atamer, A.; Can, A. S.; Hekimoglu, A.; Ilhan, N.; Yenice, N.; Kocyigit, Y.
    Human serum paraoxonase contributes to the anti-atherogenic effect of high-density lipoprotein cholesterol (HDL-C) and has been shown to protect both low-density lipoprotein cholesterol (LDL-C) and HDL-C against lipid peroxidation. We investigated the effects of rosiglitazone on paraoxonase activity and metabolic parameters in patients with type 2 diabetes mellitus [50 patients (30 males, 20 females); mean +/- SD age: 58.7 +/- 9.2 years, body mass index: 28.2 +/- 4.1 kg/m(2)], in whom glucose control could not be achieved despite treatment with metformin, sulphonylurea, and/or insulin. The patients were given 4 mg/day rosiglitazone for 3 months in addition to their usual treatment. Serum paraoxonase activity, malondialdehyde, homocysteine, and lipid profile were measured at the time of initiation and at the end of therapy with rosiglitazone. After rosiglitazone therapy, serum levels of HDL-C, apolipoprotein A-1, and paraoxonase activity increased significantly (P<0.05) and malondialdehyde, homocysteine, lipoprotein(a), and glucose levels decreased significantly (P<0.05), but no significant changes in levels of total cholesterol and apolipoprotein B were observed. Triglyceride levels also increased significantly (P<0.05). Rosiglitazone treatment led to an improvement in glycemic control and to an increase in paraoxonase activity and HDL-C levels. Although rosiglitazone showed favorable effects on oxidant/antioxidant balance and lipid profile, further studies are needed to determine the effect of rosiglitazone on cardiovascular risk factors and cardiovascular morbidity and mortality.
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    Effects of rosiglitazone on the serum paraoxonase activity and metabolic parameters in patients with type 2 diabetes
    (Elsevier Ireland Ltd, 2007) Atamer, A.; Selek, S.; Kocyigit, Y.; Ilhan, N.; Sen, T.; Atamer, Y.
    [Abstract Not Available]
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    Relationship between lentin, insulin resistance, insulin-like growth factor-1 and insulin-like growth factor binding protein-3 in patients with chronic kidney disease
    (Sage Publications Ltd, 2008) Atamer, A.; Ecder, S. Alisir; Akkus, Z.; Kocyigit, Y.; Atamer, Y.; Ilhan, N.; Ecder, T.
    This study examined the relationship between leptin, insulin-like growth factor-1 (IGF-1), IGF binding protein-3 (IGFBP-3) and insulin resistance in patients with chronic kidney disease (CKD). Levels of leptin, insulin, IGF-1, IGFBP-3 and common routine parameters were measured in 45 patients (23 males and 22 females) with CKD and 45 healthy controls matched for age, gender and body mass index. IGF-1 and IGFBP-3 levels were measured using a two-site immunoradiometric assay. Leptin levels were measured using an enzyme-linked immunosorbent assay. A homeostasis model assessment computer-solved model was used to assess insulin resistance (HOMA-IR). Levels of serum leptin, insulin, IGF-1, IGFBP-3 and HOMA-IR were significantly increased in patients with CKD compared with healthy subjects, whereas fasting blood glucose was not significantly different between the two groups. In patients with CKD, the serum leptin level was significantly correlated with IGF-1, IGFBP-3 and HOMA-IR. In conclusion, this study suggests that there is an interaction between leptin, IGF-1, IGFBP-3 and insulin resistance in patients with CKD.
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    The role of asymmetric dimethylarginine (ADMA) and leptin in hypertensive patients
    (Elsevier Ireland Ltd, 2007) Atamer, A.; Ilan, N.; Kocyigit, Y.; Toprak, G.; Ozbay, M.; Celik, Y.
    [Abstract Not Available]
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    The role of homocysteine, asymmetric dimethylarginine and nitric oxide in pre-eclampsia
    (Taylor & Francis Inc, 2012) Demir, B.; Demir, S.; Pasa, S.; Guven, S.; Atamer, Y.; Atamer, A.; Kocyigit, Y.
    Nitric oxide (NO) contributes to vasodilatation that is observed during normal pregnancy. Hyperhomocysteinaemia (HHcy) is a vascular risk factor associated with placental microvascular diseases and pre-eclampsia. Asymmetric dimethylarginine (ADMA), an endogenous inhibitor of endothelial nitric oxide synthase (NOS) has been linked to endothelial dysfunction. Maternal ADMA has been reported to be higher in women with pre-eclampsia and HHcy leads to accumulation of ADMA. The aim of this presented study is to evaluate the alterations of plasma homocysteine, ADMA and NO levels in mild pre-eclampsia. A total of 40 pre-eclamptic women and 40 healthy controls were included into the study. Mean systolic and diastolic blood pressure, mean serum homocysteine and ADMA levels were significantly higher and NO level was lower in patients. Serum homocysteine, ADMA and NO levels found to be correlated among them and with blood pressure. In conclusion, we found that homocysteine and ADMA levels were increased and NO levels decreased in pre-eclampsia.
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    Serum Levels of Lipids, Lipoproteins and Paraoxonase Activity in Pre-eclampsia
    (Sage Publications Ltd, 2011) Demir, B.; Demir, S.; Atamer, Y.; Guven, S.; Atamer, A.; Kocyigit, Y.; Hekimoglu, A.
    Serum paraoxonase 1 (PON1) activity and the oxidation of lipoproteins were investigated in 35 women with preeclampsia and in 35 healthy control women with normal pregnancies. Blood pressure, body mass index (BMI), serum levels of total cholesterol, triglycerides, high-density lipoprotein (HDL), low-density lipoprotein (LDL), apolipoprotein A1 (ApoA1), apolipoprotein B (ApoB) and lipoprotein (a) (Lp[a]), and PON1 activity were assessed. There were no significant between-group differences in subject age, gestational age at diagnosis of preeclampsia, BMI, serum total cholesterol, triglycerides, LDL and ApoB levels. Mean systolic and diastolic blood pressures and serum Lp(a) were significantly higher in subjects with pre-eclampsia than in controls. Mean serum HDL, ApoA1 and PON1 activity were significantly lower in subjects with pre-eclampsia compared with controls. In conclusion, lipids and oxidized lipoproteins may play important roles in the pathogenesis of preeclampsia.