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Öğe Distraction osteogenesis is inhibited by cancer radiotherapy with Co 60(Canadian Soc Clinical Investigation, 2009) Kesemenli, Cumhur Cevdet; Kaya, Halil; Memisoglu, Kaya; Kaya, Beyza; Dirier, Ahmet; Tosun, Bilgehan; Kilinc, NihalAim: To investigate the effects of radiotherapy on distraction osteogenesis performed on the same bone in an area that has not received radiation. Radiotherapy (Co60) was carried out in a region where tumors may develop, and then, on the assumption that the tumoral region had been removed, distraction osteogenesis was carried out, and the effects were investigated. Method: Thirty New Zealand rabbits were randomized into two groups, a study group (15 rabbits) and a control group (15 rabbits). In the study group, Co60 was administered by teletherapy to the distal half of the left tibia. Rabbits in the control group were kept in the same environment for the same period, but were not subjected to radiotherapy. Four weeks after radiotherapy, osteotomy was performed on the proximal part of the left tibia of all subjects, and distraction was carried out until 10mm. After distraction was completed, the outcomes were evaluated radiologically, scintigraphically, and histopathologically, and the results were compared. Results: New bone formation achieved through distraction osteogenesis in the study group animals was inadequate, while new bone tissue achieved in the control group was superior (P<0.001). Conclusion: Radiotherapy has a negative effect on distraction osteogenesis, even if performed on a different part of the bone.Öğe Does adding misoprostol to standard intravenous proton pump inhibitor protocol improve the outcome of aspirin/NSAID-induced upper gastrointestinal bleeding?(Springer, 2007) Yilmaz, Serif; Bayan, Kadim; Dursun, Mehmet; Canoruc, Fikri; Kilinc, Nihal; Tuzun, Yekta; Danis, RamazanAspirin and nonsteroidal anti-inflammatory drug (NSAID)-induced gastrointestinal bleeding is recognized as an important health problem. We performed a single-center randomized clinical trial to compare the effect of high-dose intravenous proton pump inhibitor (omeprazole) alone (group 1) with omeprazole in combination with a low-dose prostaglandin analog (misoprostol; group 2) on clinical outcomes in patients with aspirin/NSAID-induced upper gastrointestinal bleeding. Additionally, we evaluated the contribution of Helicobacter pylori eradication therapy on the late consequences. Patients were recruited to the study if they had upper gastrointestinal bleeding with history of taking aspirin or other NSAIDs within the week before the onset of bleeding. All were evaluated in terms of probable risk factors. After the standard treatment protocol, patients with histologically proven H pylori infection were prescribed a triple eradication therapy for 14 days. The primary end points were recurrent bleeding, surgery requirement, and death rates before discharge and at the end of follow-up period. This study lasted for 2 years. A total of 249 patients with upper gastrointestinal bleeding were admitted, and 49.7% of these patients were users of aspirin/NSAIDs. There were 67 patients in group 1 and 56 in group 2. The distributions for gender, age, comorbidity, H pylori infection, and high-risk ulcer rate were similar in both groups. Among aspirin/NSAID users, endoscopy revealed duodenal ulcer in 47 (38.2%), gastric ulcer in 10 (8.1%), and erosive gastropathy in 33 (26.8%). The overall rebleeding occurred in 12.2%, death in 2.4% of the patients. The in-hospital death (P=.414), rebleeding (P=.925), and surgery (P=.547) rates were similar in both treatment groups. After the follow-up period of 3 months, overall rebleeding occurred in 4.1%, and death in 4.8% of the patients. The overall mortality rate was highest in those > 65 years old, who were chronic low-dose aspirin users with comorbidity. One died of transfusion-related graft-versus-host disease. In this pilot study, we indicated that adding misoprostol (600 mu g/day) to standardized proton pump inhibitor treatment did not improve or change the rebleeding or mortality rates of patients with upper gastrointestinal bleeding related to aspirin/NSAID use. Other prospective studies on higher doses of misoprostol are needed to establish the coeffect. One should bear in mind that all blood products must be irradiated before transfused to the host.Öğe Effects of ELF-MF and Strontium Ranilate on Periodontium in Rats (Duble Blind)(Medwell Online, 2011) Kaya, Filiz Acun; Akdag, Mehmet Zulkuf; Kaya, Can Ayhan; Celik, Mustafa Salih; Kilinc, Nihal; Ozekinci, Selver; Saribas, EbruIn the present experimental study, it was investigated the periodontium of rats that exposed to Extremely Low Frequency-Magnetic Field (ELF-MY), overectomized bilaterally and treated with Strontium Ranelate (SR). The experiments were performed on 75 female Sprague-Dawley (4 months) rats. The rats were divided into five groups (n = 15). All rats were subjected to bilateral ovariectomy except those in I and III groups. Bilateral ovariectomy was performed before 4 days at the beginning of the experiments under ketamine anesthesia (100 mg kg(-1), intramuscularly) and II, IV and V groups animals were subjected to 1.5 mT ELF-MT exposure during 6 months, 4 h a day starting 5th day after the surgery. There were statistically significant differences among the all groups in the case of periodontal ligament, alveolar bone and gingiva (p<0.05). As a result of the study there were different levels of histopathologic changes occured between control and experimental changes in the case of all periodontal tissue examination. These results may hypothese that both ELF-MF and Strontium renalate have effects on periodontal tissues.Öğe Effects of Extremely Low Frequency Magnetic Fields on Periodontal Tissues and Teeth in Rats(Medwell Online, 2011) Kaya, Filiz Acun; Akdag, Mehmet Zulkuf; Kaya, Can Ayhan; Dasdag, Suleyman; Yavuz, Izzet; Kilinc, Nihal; Dogru, Arzum GulerThe aim of this study is to research the effects of ELF magnetic fields on periodontal tissues and teeth in rats histopathologically. The experiments were performed on 27 male Sprague-Dawley rats, aged 4 months at the beginning of the study, weighing (342.4 +/- 38.89) g and fed with standard pelleted food. The rats were divided into three groups; two experimental and one control (sham). Experimental groups were exposed to 100 and 500 mu T ELF magnetic fields during 10 months, 2 h a day, respectively. Third group was sham that were treated like experimental group except ELF magnetic fields exposure in methacrylate boxes. There was no statistical difference between the experimental groups among all tissues (p>0.05). Alveolar bone, pulp and gingiva there were statistically significant differences among the groups of sham and 1st experimental, sham and 2nd experimental (p<0.05). The statistical difference between the experimental and sham groups in the study makes us to think that ELF magnetic fields may have effects on periodontal tissues and teeth.Öğe Effects of Radiofrequency Radiation by 900 MHz Mobile Phone on Periodontal Tissues and Teeth in Rats(Medwell Online, 2008) Kaya, Filiz Acun; Dasdag, Suleyman; Kaya, Can Ayhan; Akdag, Mehmet Zulkuf; Yavuz, Izzet; Kilinc, Nihal; Kaya, SadullahThe aim of this study, is to research an answer to the question of have mobile phones effects on periodontal tissues and teeth. Twenty eight Wistar Albino adult male rats (4 months) with initial average weight of 267 +/- 15 g were obtained from the Medical Science Application and Research Center, caged individually and fed with standard pelletted food (TAVAS Inc. Adana, TR). They were separated into three groups such as cage control (n = 7), sham exposed (n = 7) and experimental (n = 14) and kept on a 14/10 h light/dark schedule. The rats were confined in a Plexiglas carousel and rat heads in the carousel exposed to 900 MHz microwave exposure emitted from generator. For the study group, rats exposed to the radiation 2 h per day (7 days in a week) for 10 months. Although, there was no statistical difference determined among the groups of experimental and sham groups (p>0.05), there were numerically more individuals effected of RF radiation in the experimental group. In our study is the statistically significant difference among the groups of experimental, sham and control groups in the case of vasodilatation in periodontal ligament and alveolar bone (p<0.05). By the histopathologic evaluation abnormal changes like vasodilatation and focal bleeding areas were determined in periodontal ligament, alveolar bone, gingiva and pulpa among some individuals. These degenerations were in different levels. These findings of our study indicates that there is need to more animal, human being and epidemiologic studies including much more individuals.Öğe Extra-adrenal myelolipoma: A case report and review of the literature(Professional Medical Publications, 2007) Kilinc, NihalMyelolipoma of the adrenal gland is a rare, benign and biochemically inactive tumor comprising mature fat and hematopoietic elements. Most of these lesions are discovered incidentally. The vast majority occurs within the adrenal glands, but extra-adrenal myelolipomas have also been reported. The typical extra-adrenal myelolipoma is a solitary, well-defined mass with in abdomen. We present a 70 year old mate who came to us with pain of 5 months duration. Abdominal ultrasound examination showed a 12 x 8.5cm hyperechoic heterogenous semi-solid mass localized in the right-side. Histological examination of the mass revealed the features of extra-adrenal myelolipoma.Öğe An Implementation for Integration of Cervical Smear Screening with Family Planning Services in the District of Diyarbakir Province of Turkey 2001(Medi+World Int, 2005) Ceylan, Ali; Ertem, Meliksah; Kilinc, Nihal; Uzunlar, Ali Kemal; Ozkaynak, VeysiContext: Cervical smear screening may have an important influence on early detection and prevention of cervical cancer morbidity and mortality and should be widely introduced particularly into primary health care settings. Objective: We tried to integrate cervical cancer screening programme with a family planning service in a family planning clinic. Design: Volunteer women, who can speak the local language, were assigned to educate residential women on cervical cancer and to refer them to a family planning clinic. All nurses working in the family planning clinic were trained on how to perform cervical smear. Setting: The study was conducted in Huzurevleri district of Diyarbakir-Turkey. Participants: The Pap test results of 503 women who gave informed consent and attended the family planning clinic for cervical smear test were the participants of the study. Women's practices and previous Pap test history were also discussed. Main Outcome Measure: To examine the effect of factors influencing Pap test history frequency tabulates, chi-square and logistic regression analyses were performed. Results: Within one year, 503 Pap test were investigated. Although 361 women (71.8%) attended clinic previously, only 37 women (7.4%) had a Pap test. Illiteracy and history of induced abortion were the factors affecting Pap test usage. Adjusted odds ratio for illiterate women, who had not had a Pap test before, was 2.80 (95% CI: 1.3-6.3) and for women who had never induced abortion was 3.88 (95% CI: 1.3-12.0). Conclusion: Integration of cervical cancer screening with family planning services may avoid missed opportunities. Especially illiterate women should be reached because of their risks.Öğe Whole-body exposure of radiation emitted from 900 MHz mobile phones does not seem to affect the levels of anti-apoptotic bcl-2 protein(Taylor & Francis Inc, 2008) Yilmaz, Fahri; Dasdag, Suleyman; Akdag, M. Zulkuf; Kilinc, NihalThe purpose of the present study was to investigate the anti-apoptotic bcl-2 protein in rat brain and testes after whole-body exposure to radiation emitted from 900 MHz cellular phones. Two groups (sham and experimental) of Sprague-Dawley rats of eight rats each were used in the study. Exposure began approximately 10 min after transferring into the exposure cages, a period of time when rats settled down to a prone position and selected a fixed location inside the cage spontaneously. For the experimental group, the phones were in the speech condition for 20 min per day for I month. The same procedure was applied to the sham group rats, but the phones were turned off Immunohistochemical staining of bcl-2 was performed according to the standardized avidin-biotin complex method. The results of this study showed that 20 mn of the radiation emitted from 900 MHz cellular phones did not alter antiapoptotic bcl-2 protein in the brain and testes of rats. We speculate that bcl-2 may affects of radiation on the brain and testes of rats. not be involved in the effects of radiation on the brain and testes of rats.
