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Öğe THE DIFFERENCES AND SIMILARITIES BETWEEN PATIENTS AND PHYSICIAN GLOBAL ASSESSMENT IN PATIENTS WITH PSORIATIC ARTHRITIS(Bmj Publishing Group, 2017) Nas, K.; Kilic, E.; Cevik, R.; Dagli, A. Z.; Kilic, G.; Sag, S.; Kamanli, A.[Abstract Not Available]Öğe The effects of curcumin on the liver and remote organs after hepatic ischemia reperfusion injury formed with Pringle manoeuvre in rats(Verduci Publisher, 2013) Oguz, A.; Kapan, M.; Onder, A.; Kilic, E.; Gumus, M.; Basarali, M. K.; Firat, U.BACKGROUND: We aimed to investigate the effects of curcumin on ischemia/reperfusion (IR) injury of the liver and distant organs resulting from liver blood flow arrest. MATERIALS AND METHODS: Totally 40 rats, divided into four groups, each included 10 rats were used. Group I as only laparatomy, Group II laparatomy and curcumin application, Group III hepatic IR; and Group IV as hepatic IR and curcumin application group. Ischemia was generated by hepatoduedonal ligament clamping for 30 minutes and then reperfusion is started. Curcumin capsules were opened and appropriate dose had been created within weighing scales. After calculations, the powder was diluted with saline. Fifteen minutes before the ischemia, curcumin was applied via oral gavage. Blood samples were taken from the animals for biochemical analysis at 60th minutes of the experiment in the first and second groups; 30 minutes after beginning reperfusion in the third and forth groups. Simultaneously, liver, lung and kidney tissues were sampled for biochemical and histopathological examinations. RESULTS: Plasma malondialdehyde levels were found to be higher (p < 0.001), but total antioxidant activity values were not different in IR group compared with IR + curcumin group (p > 0.05). Biochemical and histopathological evaluation of tissue samples revealed that there were no differences in total antioxidant activity, total oxidant activity and histopathologic scores in IR + curcumin group compared with values of IR group (p > 0.05). CONCLUSIONS: Curcumin did not reduce the effects of hepatic ischemia reperfusion injury on the liver and distant organs including kidneys and lungs significantly.Öğe Effects of melatonin on behavioral changes of neonatal rats in a model of cortical dysplasia(Verduci Publisher, 2013) Karadeli, H. H.; Aktekin, B.; Yilmaz, B.; Kilic, E.; Uzar, E.; Aci, A.; Bingol, C. A.BACKGROUND: Cortical dysplasia (CD) is associated with several behavioral disorders in both the pediatric and the adult population. The effect of melatonin on behavioral disorders in rats generated CD has not been investigated so far. AIM: To investigate the effects of melatonin administration on activity and anxietic behavior of neonatal rats in a model of CD. MATERIALS AND METHODS: Newborn Sprague-Dawley rats (n=21) were randomized into three groups. On postnatal day 1, one freeze lesion was carried out in 14 rats between bregma and lambda to create a CD model. Another group of neonatal rats served as control group (n=7). Those 14 rats were either administered melatonin (n=7) or vehicle solution (n=7). Melatonin treatment (4 mg/kg/day, i.p.) was initiated ten days after induction of cold injury and continued for three weeks. Animal activity and anxiety were analyzed by using open field and elevated plus maze tests 24h after the last melatonin administration (day 32) in a blind manner. RESULTS: It was observed that CD induced animals spent significantly less time in the open field area when compared to the other groups (p < 0.01). Additionally, the time spent in the open field area was significantly elevated in the melatonin-treated animals compared to both the control and the CD groups (p < 0.01). Accordingly, anxiety scores in the CD group was significantly increased (p < 0.01), and this effect could be reversed by administration of melatonin. CONCLUSIONS: Melatonin exerts protective behavioral effects against cortical dysplasia in newborn rats. Further clinical investigations may prove melatonin as a useful therapeutic adjunct to prevent from possible behavioural damages of cortical dysplasia.Öğe GENDER SPECIFIC DIFFERENCES IN PATIENTS WITH PSORIATIC ARTHRITIS(Bmj Publishing Group, 2015) Nas, K.; Capkin, E.; Dagli, A. Z.; Cevik, R.; Kilic, E.; Kilic, G.; Karkucak, M.[Abstract Not Available]Öğe IMPACT OF DISEASE ACTIVITY ON PHYSICAL FUNCTION AND HEALTH-RELATED QUALITY OF LIFE IN PATIENTS WITH PSORIATIC ARTHRITIS(Bmj Publishing Group, 2017) Nas, K.; Kilic, G.; Cevik, R.; Dagli, A. Z.; Kilic, E.; Sag, S.; Erkorkmaz, U.[Abstract Not Available]Öğe The protective effects of pomegranate on liver and remote organs caused by experimental obstructive jaundice model(Verduci Publisher, 2016) Yilmaz, E. E.; Arikanoglu, Z.; Turkoglu, A.; Kilic, E.; Yuksel, H.; Gumus, M.OBJECTIVE: We aimed to investigate the protective potential of pomegranate extract on the liver and remote organs in rats with obstructive jaundice. MATERIALS AND METHODS: The rats were split into 4 groups. In Group 1 (G1) (sham group) rats, the common bile duct was mobilized without any ligation. Group 2 (G2) received a combination of the sham operation and synchronous treatment with pomegranate. Group 3 (G3) received common bile duct ligation (CBDL). Group 4 (G4) were subjected to CBDL and treatment with pomegranate. After 8 days, we measured total oxidative status (TOS) and antioxidant capacity in the rats' liver tissue and remote organs, and evaluated blood levels of malondialdehyde and total antioxidant capacity (TAC). RESULTS: G3 rats showed significantly raised malondialdehyde level as compared to G1 rats (p < 0.001). Following the pomegranate therapy, a decrease in malondialdehyde was observed (p = 0.015). TAC levels were significantly raised in the G3 rats compared to the G1 rats (p = 0.004). TAC levels dropped after pomegranate therapy (p = 0.011). CBDL caused elevated TOS levels in the liver and remote organs, with a statistically significant increase in the lung tissue (p = 0.002). TOS levels in the CBDL groups decreased after pomegranate treatment (p < 0.001). CONCLUSIONS: This study reveals the marked protective effect of pomegranate on the liver and remote organs in obstructive jaundice.Öğe Serum soluble lectin-like oxidized low-density lipoprotein receptor-1 levels in patients with restless legs syndrome(Comenius Univ, 2016) Halac, G.; Kilic, E.; Cikrikcioglu, M. A.; Celik, K.; Toprak-Erek, A.; Keskin, S.; Gultepe, IOBJECTIVE: The aim of this study was to assess the predisposition for atherosclerosis in patients with RLS through serum sLOX-1 (serum Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1) measurements. BACKGROUND: Recent epidemiological studies have suggested an association of RLS with certain chronic conditions such as diabetes mellitus (DM), obesity, hypertension (HT), and hyperlipidemia. LOX-1 is expressed in endothelial cells, macrophages, and in smooth muscle cells under the effect of proatherogenic conditions. METHODS: This study was a prospective, cross-sectional, case-controlled. We measured the serum sLOX-1 levels in 37 restless legs syndrome patients and 38 controls. RESULTS: Serum sLOX-1 level was significantly lower in the patient group. The two groups were similar in glucose, HbA1c, creatinine, LDL cholesterol, TG, HDL, total protein, albumin, AST, ALT, GGT, ALP, HGB, HCT, MCV, transferrin saturation rate (TSR), ferritin, CRP, TSH, FT4, FT3, B12, and folic acid levels. Also the two groups were similar with respect to age at menarche, number of previous births, number of abortions and/or curettage, total duration of breastfeeding, percentage of patients in menopause, and age at menopause. CONCLUSION: Our results may suggest a lower atherosclerotic risk among RLS patients as compared to the general population (Tab. 3, Ref. 33). Text in PDF www.elis.sk.Öğe VALIDITY OF ASDAS AND BASDAI AS A MEASURE OF DISEASE ACTIVITY IN AXIAL PSORIATIC ARTHRITIS(Clinical & Exper Rheumatology, 2014) Kilic, G.; Kilic, E.; Nas, K.; Karkucak, M.; Capkin, E.; Dagli, A. Z.; Cevik, R.[Abstract Not Available]Öğe WOMEN WITH PSORIATIC ARTHRITIS WHO ARE HOMEMAKERS OR OFFICE WORKERS DECLARE SIMILAR DIFFICULTIES DURING WORKING(Bmj Publishing Group, 2016) Kilic, E.; Kilic, G.; Nas, K.; Cevik, R.; Capkin, E.; Dagli, A. Z.; Karkucak, M.[Abstract Not Available]
