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Öğe The effects of osteoporosis on distraction osteogenesis: An experimental study in an ovariectomised rabbit model(2003) Arslan H.; Ketani A.; Gezici A.; Kapukaya A.; Necmioğlu S.; Kesemenli C.; Subasi M.The effects of oestrogen deficiency-associated osteoporosis on callus distraction were investigated in rabbits. Twenty-four female New Zealand rabbits 5 to 6 months old were used. Ovariectomy was performed on 12 rabbits, which composed the osteoporotic model group. Six weeks later, osteotomy was carried out and Ilizarov external fixators were applied to the right proximal tibial metaphyses in both the osteoporotic model group and the control group. Beginning one week postosteotomy, the metaphyses were distracted 0.35 mm twice daily for 3 weeks, and the average length increase obtained for both groups was 17.2 mm (minimum: 16.8, maximum: 19 mm). Following a postdistraction waiting period of 6 weeks for newbone formation, the subjects were sacrified and specimens were examined histopathologically. Radiography was carried out at one-week intervals during the distraction period and at 2-week intervals during the waiting period, and scintigraphy was performed at the end of each period. On histopathologic examination, a significant difference in callus remodeling was observed between the control and osteoporotic model groups. On radiologic evaluation it was observed that, while both groups had inadequate callus tissue at the end of the waiting period, callus formation and remodeling occurred later in the model group than in the control group, and the new bone was more osteoporotic. Osteoporosis associated with estrogen deficiency adversely affects the outcome of callus distraction. Nonetheless, radiographic findings in rabbits indicate that the effects may not be so great as to preclude clinical procedures. It was concluded that these results should be supported with clinical studies.Öğe Evaluation of the antioxidant and renoprotective effects of ellagic acid on ischemia / reperfusion induced nephropathy in rats(Acta Medica Mediterranea, 2014) Yildirimi Y.; Aba Adıyaman, Özlem; Yilmaz Z.; Kadiroglu A.K.; Yilmaz M.E.; Gül M.; Ketani A.Aims: Renal ischemia-reperfusion (I/R) injury is one of the important cause of acute kidney injury (AKI). Reactive oxygen species and inflammatory cytokines play major role in the pathogenesis of IR injury. Ellagic acid (EA), a phenolic compound, have shown to exert antioxidants, anti-inflammatory, anticarcinogenic, antihyperlipidemic effects. We aim to evaluate, the effect of EA on renal I/R induced nephropathy in rats. Materials and methods: Twenty-eight male Sprague-Dawley rats were divided into four groups; control, control + EA, I/R, and EA+I/R. EA (85 mg/kg, perorally) was administered 30 min prior to the ischemia. Rats were unilaterally nephrectomized and subjected to 45 min of renal pedicle occlusion followed by 60 min of reperfusion. Both groups were subsequently studied by renal function tests, oxidant and antioxidant parameters, and kidney histology. Results: Serum/kidney TAC, NO and paraoxonase levels were significantly higher, while serum urea and creatinine, serum/kidney MDA and TOS were significantly lower in EA+I/R group compared to I/R group (p<0.05). Histopathologic examination revealed that the severity of damage was significantly lower in the EA+I/R group compared to the I/R alone group. Conclusion: Administration of EA appears to have beneficial effects on I/R induced renal injury by reducing oxidative stress, thus preventing histological injuries and bringing about an improvement in renal function.Öğe Histopathologic effect of gonadal steroids and gender on goiter development in thyroid stimulated rabbits by TRH(1995) Aydin I.; Nergiz Y.; Ketani A.; Aslan I.In order to assess the effect of gender and gonadal steroids on goiter development, thirty-two New Zealand albino rabbits were studied. The experimental protocol was based on histopathological changes observed in the thyroid gland following manipulation of gonadal hormone levels and stimulation by TRH. Gender differences for the structure end size of follicles following TRH administration remained significantly larger in females than in males (p < 0.001). In gonadectomied male and female groups, there appeared to be a quantitative difference in response to TRH. Follicular cell proliferation and papillary structures were prominent and the diameter of the follicles was significantly larger in males compared with females (P < 0.001). In gonadectomied rabbits treated with the opposite gonadal steroids, the appearance of papillary structures and basophilic character of the colloid on staining were also prominent in males. The results indicate that (i) estrogen promotes while androgen inhibits to some extent the stimulatory effects of TRH on thyroid follicular size; and (ii) although the data would support the effect of gender and sex steroids on goiter development, factors other than gonadal steroids are responsible for the higher incidence of goiter in females.Öğe Pretreatment with paricalcitol attenuates oxidative stress in renal ischemia reperfusion-induced nephropathy in rats(Science Printers and Publishers Inc., 2020) Aydin F.Y.; Yilmaz Z.; Yildirim Y.; Aydin E.; Ketani A.; Bahadir V.; Brahim Kaplan I.OBJECTIVE: To investigate whether paricalcitol could ameliorate kidney injury due to ischemia reperfusion (I/R) in an experimental study. STUDY DESIGN: Rats were divided into 4 groups: control, paricalcitol, I/R, and paricalcitol+I/R, each containing 7 animals. Intraperitoneal 0.3 ?g/kg paricalcitol was administered to rats once a day for 5 consecutive days in the paricalcitol and paricalcitol+I/R groups. After right nephrectomy, rats were exposed to ischemia/ reperfusion on day 6 in the paricalcitol+I/R and I/R groups. Oxidant and antioxidant parameters, kidney function tests, and histology were investigated. RESULTS: Serum urea and creatinine levels exhibited a significant decrease in rats treated with paricalcitol before I/R as compared to rats exposed just to I/R. In a comparison of the paricalcitol+I/R group with the I/R group, serum total oxidant status (TOS) levels decreased significantly; serum total antioxidant capacity (TAC) and nitric oxide levels, however, increased significantly with paricalcitol administration. Malondialdehyde and TOS levels of kidney tissue were significantly lower, whereas TAC and paraoxonase levels were higher in the paricalcitol+I/R group than in the I/R group. Renal tissue injury scores were found to be significantly higher in the I/R group than in the paricalcitol+I/R group. CONCLUSION: Pretreatment with paricalcitol was detected to be renoprotective by decreasing renal injury related with renal I/R, which was assessed by improved renal function and histopathology. © Science Printers and Publishers, Inc.
