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Öğe Effects of Ovariectomy and Bilateral Molar Teetless on Mandibular Condyle of Rat(Medwell Online, 2012) Zengingul, A. I.; Ketani, S.; Karadede, M. I.; Uysal, E.; Ketani, M. A.This study, researchers examined the ovariectomy and bilateral molar teetless of mandibular condyle in rat by histologically and histomorphometrically. In this part of the study, 12 Wistar Albino rats, 120 days old and weighing 200-250 g were used. The rats were divided into three groups, a control and two experimental group. The experimental groups of rats were subjected to ovariectomy in. order to create oestrogen deficiency and bilateral molars extraction. After 35 days of ovariectomy, control and experimental group rats were killed and their mandible condyle removed. The speciemens were stained with Hematoxylin and Eosin (HE) and examined for structure of histologically and histomorphometrically. Histomorphometric analysis; mandibular condyle of control and experimental groups were statistically significant results of the histological layers (p<0.05). It was concluded that ovariectomy application and molar teetless can induce histopathological and histomorphometrically changes in the structure of the condyle.Öğe THE EFFECTS OF SIALOADENECTOMY AND EPIDERMAL GROWTH FACTOR ON GINGIVAL TISSUE IN RATS: AN ULTRASTRUCTURAL STUDY(Diagnosis Press Ltd, 2008) Dag, A.; Ketani, M. A.; Zengingul, A. I.; Ketani, S.Submandibular salivary glands (SMGs) synthesize, accumulate and secrete a large amount of epidermal growth factor (EGF) in rats. EGF stimulates cell proliferation and differentiation by binding to its reseptors (EGFR). The aim of the present study was to mimic an endogenous epidermal growth factor deficiency through sialoadenectomy in paralel to exogenous EGF administration and to observe the ultrastructural changes in rat gingival tissue, employing electron microscopy Thirty adult female Wistar albino rats were divided randomly into three groups: a control group (n:10), a sialoadenectomy group (n:10) and a sialoadenectomy group to which an EGF was administered (n: 10). The experimental groups of rats were subjected to sialoadenectomy in order to create EGF deficiency. After 2 7 days both control and experimental rat groups were euthanized by pentobarbital and their gingival tissue was removed. Tissue samples from gingiva were processed for ultrastructural study Electron microscopic evaluation indicated that while in the control group gingival tissues showed a normal appearance changes were observed in the experimental groups. We observed a partial degeneration of the epithelial cell junctions. Widespread crystolisis was also observed in a group of mitochondria. It is concluded that epidermal growth factor deficiency achieved by sialoadenectomy caused ultrastructural changes in gingival epithelium.Öğe Effects of unilateral molar teeth less condition on the mandibular condyle of rats(Indian Veterinary Journal, 2006) Zengingul, A. I.; Dag, A.; Nigiz, R.; Ketani, S.[Abstract Not Available]Öğe A Macro-Anatomical Investigation of the Some Skull Bones of Nehring's Blind Mole Rats (Spalacidae: Nannospalax nehringi)(Wiley, 2017) Ketani, S.; Kilinc, M.; Erdogan, S.; Kaya, A.; Coskun, Y.This study was aimed to demonstrate the specific anatomical features of the skull bones of Nehring's blind mole rats. Eight skulls, belonging to animals of both sexes, were used. The occipital squama contributed to the formation of the caudal portion of the skull roof. The foramen magnum was quite large. The external occipital crest was present only in the males. The parietal bones formed the middle portion of the skull roof together with the well-developed inter-parietal bones. The zygomatic process of the temporal bone formed the zygomatic arch by extending to the temporal process of the zygomatic bone. The zygomatic process of the frontal bone and the frontal process of the zygomatic bone laterally bordered the orbit. There was a single septal process of the nasal bone. Each ramus of the mandibula had four processes. The mandibular ramus had an angular process on its caudal rim, which extended dorsolaterally. The dorsal free end of the mandibular ramus possessed a coronoid process. In the back, there were two other processes, situated medially and laterally. The medially situated process was referred to as a condylar process, and the laterally situated process was referred to as an alveolar process. The alveolar process detected on the mandibular ramus has not been reported in any rodent species, other than those of the family Spalacidae. Blind mole rats can be a real eye-opener for evolutionary science. The burrowing rodents are key to answering a controversial question about how new species arise.Öğe Morphological Study by Scanning Electron Microscopy of the Lingual Papillae in the Middle East Blind Mole Rat (Spalax ehrenbergi, Nehring, 1898)(Wiley, 2010) Kilinc, M.; Erdogan, S.; Ketani, S.; Ketani, M. A.P>There is no definite information about the tongue morphology of blind mole rats owing to spreading of these animals to only a certain habitat. For this reason, we aimed to examine the morphological structure of the tongue by scanning electron microscopy (SEM) in this species. In this study, the tongues of four blind mole rats were used and the morphology of its lingual surface, different types of papillae, their characteristics and topographical distribution was described. Three types of papillae (filiform, fungiform and vallate) and lingual prominence were observed. The dorsal surface of the tongue was covered by filiform papilla; and filiform papillae demonstrated the most numerous type of lingual papilla. Fungiform papillae were rounded in shape and randomly distributed particularly on the anterior and medial region. In addition, each fairly convex fungiform papilla was surrounded by a continuous circular pad like a crown. The two oval vallate papillae were situated symmetrically on the posterior region and obliquely to the median line of the tongue. The body of vallate papillae was surrounded by a continuous trench and mucosal folds. The lingual prominence between medial and posterior region and a transversal groove just in front of it were observed. Furthermore, a limited tuber and root based diet and gnawing have together resulted in similarity of the tongue of the rodent, giving it some characteristics typical of a herbivore and an insectivore.
