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  • Küçük Resim
    Öğe
    The effects of endogenous epidermal growth factor deficiency and exogenous epidermal growth factor administration on rat kidney
    (2006) Ketani, Muzaffer; Ünver, Özkan
    The objective present study was to determine sialoadenectomy and exogenous EGF administration effects on light microscopic changes in a rat kidney. Adult female Wistar albino rats used. The animals divided into three groups randomly. Group-I: The animals served as control (n:10). Group-II: Sialoadenectomy (n:10), Group-III: Sialoadenectomy+EGF administration (n:10). After 27 days sialoadenectomy, Control and experimental groups rats were killed by pentobarbital and their kidney removed. The tissue samples were examined under light microscope. Light microscopic evaluation indicated that the kidney tubules epithelium and glomerules in control group showed a normal appearance while changes were observed in all experimental groups. However, SX+ exogenous EGF administration group was performing a nearer light microscopic view of to the control group. In this study we indicated that short term exogenous EGF supplementation in sialoadenectomized rats can relativly increase kidney light microscopic improvoment.
  • Küçük Resim
    Öğe
    Epidermal growth factor receptor (egfr) immunolocalization in the sialoadenectomized rat ovaries
    (2004) Ketani, Muzaffer; Kaloǧlu, Celal; Ketani, Şennur; Uysal, Ersin
    Intra-ovarian regulation of follicular maturation is modulate by various factors. Among these, Epidermal growth factor (EGF) is vital factor. Epidermal growth factor (EGF) have potent mitogenic effects on granulosa and theca cells. The aim of present study was to investigate the effects of sialoadenectomy on the distrubution of immunoreactive epidermal growth factor receptor (EGFR) in the rat ovaries. Twenty Adult female Wistar albino rats were divided into two groups, a control and one experimental groups. The experimental groups of rats were subjected to sialoadenectomy in order to create EGF deficiency. After 60 days of sialoadenectomy (EGF deficiency) and control group rats were killed by pentobarbital and their ovaries removed. The sections were stained with APAAP immunohistochemical staining for evaluation using a light microscope. A statistically significant reduced body weight was noted in the experimental groups of rats when compared to the control group. This marked EGFR immunoreactivity was maintained in control rat ovaries, whereas it deacreased in sialoadenectomized rat ovaries. In conclusion, the present study indicated that there is paralel relationship between ovary follicule cells EGFR immunolocalization and EGF deficiency.