Yazar "Keskin C." seçeneğine göre listele

Listeleniyor 1 - 3 / 3
  • [ X ]
    Öğe
    Composition of essential oil of Carthamus glaucus Bieb. subsp. glaucus
    (Chemical Publishing Co., 2008) Toker Z.; Keskin C.
    The essential oil of water distilled aerial parts of Carthamus glaucus Bieb. subsp. glaucus (Compositae) was analyzed by GC/MS. 23 Components were characterized representing 87.3% of total component in oil sample. The major components were linalool (38.5%), longifolene (6.8%) and caryophyllene oxide (6.2%).
  • [ X ]
    Öğe
    In-vitro antioxidant, cytotoxic, cholinesterase inhibitory activities and anti-genotoxic effects of hypericum retusum aucher flowers, fruits and seeds methanol extracts in human mononuclear leukocytes
    (Iranian Journal of Pharmaceutical Research, 2017) Keskin C.; Aktepe N.; Yükselten Y.; Asuman; Boğa M.
    The present study investigates the antioxidant, anticancer, anticholinesterase, anti-genotoxic activities and phenolic contents of flower, fruit and seed methanol extracts of Hypericum retusum AUCHER. The amounts of protocatechuic acid, catechin, caffeic acid and syringic acid in methanol extracts were determined by HPLC. Total phenolic content of H. retusum seed extract was found more than fruit and flower extracts. The DPPH free radical scavenging activity of flower and seed methanol extracts showed close activity versus BHT as control. Among three extracts of H. retusum only flower methanol extract was exhibited considerable cytotoxic activities against to HeLa and NRK-52E cell lines. Moreover, seed methanol extract showed both acetyl and butyrl-cholinesterase inhibitory activity. The highest anti-genotoxic effects were seen 25 and 50 ?g/mL concentrations. In this study, the extracts showed a strong antioxidant and anti-genotoxic effect. The seed extract was more efficient- than extracts of fruit and flowers. Our results suggest that the antioxidant and anti-genotoxic effects of extracts depend on their phenolic contents. Further studies should evaluate the in-vitro and in-vivo the benefits of H. retusum seed methanol extracts. © 2017 by School of Pharmacy.
  • [ X ]
    Öğe
    Trace metal determination in the medicinal plant hyoscyamus (solanaceae) by inductively coupled plasma optical emission spectrometry
    (Perkin - Elmer Corp., 2014) Keskin C.; Kisin E.; Yavuz M.
    The concentrations of Cd, Ni, Cu, Pb, Cr, Fe, B, and A1 were determined in four different medicinal plants of the Hyoscyamus species: Hyoscyamus reticulums L, Hyoscyamus leptocalyx STAPF, Hyoscyamus aureus L, and Hyoscyamus albus L by ICP-OES. By considering the sensitivity of ICP-OES with respect to the trace level determination of Cd, Ni, Cu, Pb, Cr, Fe, B, and Al in the studied plant samples and the limitations of sample amount possible in a microwave digestion procedure, the ashing method was applied before analysis and proved the quantitative measurements of the elements.The accuracy of the method was verified by comparison to the certified reference sample NCSZC 73014 Tea Leaves. The RSD values were between 0.14-10.4%, while the error values were in the 90-107% range. The results show that with the proposed method higher concentrations of Ni, Cr, Pb, Fe, and B were determined in H. aureus. Interestingly, the concentration of Cu in H. reticulatus was approximately 48.5 times higher than the mean Cu values of the other three Hyoscyamus species, while the Pb concentration levels in H. aureus were 17.8 times higher than in the H. reticulatus L, H. leptocalyx STAPF, and H. albus L species.