Yazar "Kepenek, Ferat" seçeneğine göre listele

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    Comparison of (18F)FDG PET/CT and (68Ga)DOTATATE PET/CT imaging methods in terms of detection of histological subtype and related SUVmax values in patients with pulmonary carcinoid tumors
    (Lippincott Williams & Wilkins, 2019) Komek, Halil; Can, Canan; Urakci, Zuhat; Kepenek, Ferat
    Objective This study was designed to compare the 18-Fluorodeoxyglucose positron emission tomography/computed tomography [(F-18)FDG PET/CT] and 1,4,7,10-tetraazacyclododecane-NI,NII,NIII,NIIII-tetraacetic acid (D)-Phe1-thy3-octreotate [(Ga-68)DOTATATE PET/CT) findings in patients with pulmonary carcinoid (PC) tumors. Materials and methods A total of 20 patients [mean (SD) age: 52.2 (12.9) years, 60% women] with PC tumors and available records on digital images of (F-18)FDG PET/CT and (Ga-68)DOTATATE PET/CT and histopathological analysis were included in this retrospective single-center study. Patient characteristics, structural and functional imaging, and final histopathology were recorded in all patients. Typical and atypical PC tumors were compared in terms of patient age, tumor site, tumor size, and SUV max values obtained by (F-18)FDG PET/CT and (Ga-68)DOTATATE PET/CT imaging. Results Overall, median (minimum-maximum) SUVmax values were 3.2 (1.2-11.2) in (F-18)FDG PET/CT and 17.2 (2.5-89.0) in (Ga-68)DOTATATE PET/CT. Atypical PC tumor was associated with significantly higher mean +/- SD age (64.6 +/- 5.4 vs. 45.5 +/- 10.5 years, P=0.036) and median (minimum-maximum) (F-18)FDG PET/CT SUVmax values [7.3 (4.8-11.2) vs. 2.4 (1.2-3.9), P=0.003], but with significantly lower median (minimum-maximum) (Ga-68)DOTATATE PET/CT SUVmax values [6.4 (2.5-10.6) vs. 23.7 (14.2-89), P<0.001], compared with typical PC tumor. (F-18)FDG PET/CT and (Ga-68)DOTATATE PET/CT SUVmax values were negatively correlated (r=-0.429, P=0.011). Conclusion Our findings in patients with histologically proven PC tumors showed higher SUV max values for (F-18)FDG PET/CT in atypical PC tumors and for (Ga-68)DOTATATE PET/CT in typical PC tumors. Our findings indicate the likelihood of higher detection rates particularly for typical PC tumors by (Ga-68)DOTATATE PET/CT imaging and the potential utility of the SUVmax ratio in predicting the histological subtype of PC tumors.
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    Comparison of 18F-FDG PET/CT and 68Ga-FAPI-04 PET/CT in patients with non-small cell lung cancer
    (Lippincott Williams & Wilkins, 2022) Can, Canan; Kepenek, Ferat; Komek, Halil; Gundogan, Cihan; Kaplan, Ihsan; Tasdemir, Bekir; Guzel, Yunus
    Aim In this study, we aimed to compare the diagnostic accuracy of F-18-fluorodeoxyglucose (F-18-FDG) and Gallium-68 labeled fibroblast activator protein inhibitor (Ga-68-FAPI)-04 PET/CT in the tumor-node-metastasis (TNM) staging of patients with nonsmall cell lung cancer (NSCLC) and investigate whether adenocarcinoma (ADC) and squamous cell cancer (SCC) exhibit different uptake patterns on Ga-68-FAPI-04 PET/CT. Materials and method Twenty-nine patients with a histopathologically-confirmed diagnosis of NSCLC, who had no history of previous radiation therapy or chemotherapy and underwent F-18-FDG PET/CT and Ga-68-FAPI-04 PET/CT imaging between January 2021 and December 2021 were included in this retrospective study. Staging was performed using the 8th edition of the TNM staging system on both F-18-FDG PET/CT and Ga-68-FAPI-04 PET/CT images. Standardized uptake value (SUV)(max) and tumor-to-background ratios (TBR) were calculated on primary lesions and metastases. Results There was no statistically significant difference in primary lesions in terms of SUVmax and TBR values. However, Ga-68-FAPI-04 PET/CT was significantly superior to F-18-FDG PET/CT in terms of the number of lymph nodes and bone metastases revealed. The SUVmax and TBR values of lymph nodes, hepatic lesions and bone lesions were significantly higher on Ga-68-FAPI-04 PET/CT than on F-18-FDG PET/CT. Ga-68-FAPI-04 PET/CT changed the disease stage of three patients (10.9%). The diagnostic accuracy of Ga-68-FAPI-04 PET/CT was 100%, whereas the diagnostic accuracy of F-18-FDG PET/CT was 89.6% (P = 0.250). Conclusion Although Ga-68-FAPI-04 PET/CT detected more lesions and higher diagnostic accuracy than F-18-FDG PET/CT in NSCLC, neither method was statistically superior to each other in terms of diagnostic accuracy in TNM staging.
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    Comparison of the role of 18F-fluorodeoxyglucose PET/computed tomography and 68Ga-labeled FAP inhibitor-04 PET/CT in patients with malignant mesothelioma
    (Lippincott Williams & Wilkins, 2023) Guezel, Yunus; Koemek, Halil; Can, Canan; Kaplan, Ihsan; Kepenek, Ferat; Ebinc, Senar; Bueyuekdeniz, Mehmet Perver
    ObjectiveIn this study, we aimed to compare the role of Ga-68-labeled FAP inhibitor (Ga-68-FAPI)-04 PET/computed tomography (CT) and F-18-fluorodeoxyglucose (F-18-FDG) PET/CT in the evaluation of primary tumor and metastases in patients diagnosed with malignant mesothelioma. Materials and methodsOur prospective study included 21 patients with histopathological diagnosis of malignant mesothelioma who underwent both Ga-68-FAPI-04 PET/CT and F-18-FDG PET/CT imaging between April 2022 and September 2022. Maximum standardized uptake value (SUVmax), metabolic tumor volume, total lesion glycolysis, tumor-to-background ratio (TBR) and highest SUVpeak (HPeak) values and lesion numbers were calculated from primary and metastatic lesions on FDG and FAPI PET/CT images. Findings obtained from FAPI and FDG PET/CT were compared. ResultsMore lesions were detected in Ga-68-FAPI-04 PET/CT compared to F-18-FDG PET/CT in primary tumor and lymph node metastases. Statistically significantly higher SUVmax and TBR values were found with FAPI PET/CT (primary lesion SUVmax and TBR, P = 0.001 and P < 0.001, respectively; lymph node SUVmax and TBR, P = 0.016 and P = 0.005, respectively). With FAPI PET/CT, upstage was observed according to tumor-node-metastasis staging in a total of seven patients including three patients with pleural origin, three patients with peritoneal origin and one patient with pericardial origin. ConclusionIn addition to the stage change with Ga-68-FAPI-04 PET/CT in malignant mesothelioma patients, a statistically significant superiority was observed in SUVmax, TBR and volumetric parameters in primary tumors and metastases.
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    The effect of coronavirus disease 2019 pneumonia on myocardial ischemia detected by single-photon emission computed tomography myocardial perfusion imaging
    (Lippincott Williams & Wilkins, 2022) Bilge, Onder; Komek, Halil; Kepenek, Ferat; Tastan, Ercan; Gundogan, Cihan; Tatli, Ismail; ozturk, Cansu
    Objective We aimed to examine the effects of COVID-19 pneumonia on cardiac ischemia detected by myocardial perfusion imaging with single-photon emission computed tomography myocardial perfusion imaging (SPECT-MPI) in patients presenting with chest pain and shortness of breath after recovery from COVID-19. Materials and method Patients with a history of COVID-19 confirmed by reverse transcriptase-PCR test who underwent SPECT-MPI for the evaluation of ischemia with the complaints of chest pain and shortness of breath were screened for this study. Patients who underwent thorax CT during the acute period of the COVID-19 were included. Patients with and without pneumonia were determined based on computed tomographic criteria. The patients with a summed stress score of at least 4 on SPECT-MPI were considered to have abnormal MPI in terms of ischemia. Results A total of 266 patients were included in the study. Sixty-five (24%) patients had ischemia findings on SPECT-MPI. Thorax CT showed pneumonia in 152 (57%) patients, and the patients were divided into two groups as pneumonia and nonpneumonia. Abnormal SPECT-MPI scores, which represented myocardial ischemia, were higher in the pneumonia group. Multivariate logistic regression analyses showed that the presence of hyperlipidemia and pneumonia on CT increased the risk of ischemia on SPECT-MPI (OR, 2.08; 95% CI, 1.08-3.99; P-value = 0.029; and OR, 2.90; 95% Cl, 1.52-5.54; P-value = 0.001, respectively). Conclusion COVID-19 pneumonia was identified as an independent predictor of ischemia on SPECT-MPI. Symptoms including chest pain and shortness of breath in patients who have had COVID-19 pneumonia may be attributed to coronary ischemia.
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    Incidental Detection of a Type B3 Thymoma on 68Ga-FAPI-04 PET/CT Imaging
    (Lippincott Williams & Wilkins, 2023) Kepenek, Ferat; Gundogan, Cihan; Kaplan, Ihsan; Sogutcu, Nilguen; Can, Canan
    F-18-FDG PET/CT performed for staging of colon cancer in a 60-year-old woman revealed a thymic neoplasm with increased radiopharmaceutical uptake in the anterior mediastinum. Ga-68-FAPI PET/CT showed low FAPI uptake in the anterior mediastinal mass. The patient was diagnosed with type B3 thymoma by histopathologic evaluation. In this case, thymoma demonstrated lower uptake with FAPI than FDG. Larger studies are required for the differentiation of malignant and benign mediastinal masses with FAPI.
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    Perirenal Infiltration of Signet Ring Cell Colon Carcinoma Shown by 68Ga-FAPI PET/CT
    (Lippincott Williams & Wilkins, 2022) Guzel, Yunus; Kaplan, Ihsan; Kepenek, Ferat; Sogutcu, Nilgun; Komek, Halil
    A soft tissue lesion surrounding the left kidney was detected in F-18-FDG PET/CT performed with suspicion of recurrence in a patient who was operated for descending colon cancer and showed mild FDG uptake. Intense fibroblast activation protein-specific inhibitor (FAPI) uptake in the perirenal soft tissue was observed in Ga-68-FAPI-04 PET/CT. Tru-cut biopsy of the left perirenal lesion revealed signet ring cell colon carcinoma metastasis. This case demonstrated that Ga-68-FAPI-04 PET/CT could be a promising radiopharmaceutical for the evaluation of signet ring cell colon carcinomas.
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    The role of basal metabolic and volumetric 18F-FDG PET/CT 18 parameters and their changes in predicting pathological complete response in breast cancer patients receiving neoadjuvant chemotherapy
    (Hellenic Soc Nuclear Medicine, 2022) Kepenek, Ferat; Karaoglan, Huseyin; Can, Canan; Komek, Halil; Kaplan, Ihsan; Etem, Hulya; Ebinc, Senar
    Objective: The aim of this study is to investigate the roles of pre-and post treatment quantitative fluorine-18-fluorodeoxyglucose ( F-FDG) positron emission tomography/computed tomography (PET/CT) para-18 meters including maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) and their rate of change in predicting pathological complete response (pCR) in patients with local and locally advanced invasive breast cancer receiving neoadjuvant chemotherapy (NAC). Subjects and Methods: Ninety-eight patients who received NAC after being diagnosed with local and locally advanced invasive breast cancer between January 2017 and September 2021 were retrospectively included in our study. Molecular subtypes of all patients were determined. Maximum SUV, MTV, TLG, percent change in SUVmax (ASUVmax), AMTV, and ATLG obtained from PET/CT scans performed before and after NAC were calculated. The cut-off, area under curve (AUC), sensitivity, and specificity values of these parameters in predicting pCR were calculated using receiver operating characteristic (ROC) curves. Results: ATMTV (cut-off 94.01%, AUC: 0.846), ATTLG (cut-off 97.36%, AUC: 0.870), B2MTV (cut-off < 1.75, AUC: 0.764), B2TLG (cut-off < 2.11, AUC: 0.764), B2SUVmax (cut-off < 1.58, AUC: 0.767), ABMTV (cut-off 93.67%, AUC: 0.851), ABTLG (cut-off 97.22%, AUC: 0.870), ABSUVmax (cut-off 84.99%, AUC: 0.846) calculated using ROC curves were found to significantly predict pCR with high sensitivity and specificity. Conclusion: We concluded that meta-bolic and volumetric PET/CT parameters, the rates of their change, and metabolic res-ponse during NAC may be important variables in predicting pCR in patients with breast cancer.
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    Role of volumetric parameters obtained from 68 Ga-PSMA PET/CT and 18F-FDG PET/CT in predicting overall survival in patients with mCRPC receiving taxane therapy
    (Springer, 2023) Guzel, Yunus; Komek, Halil; Can, Canan; Kaplan, Ihsan; Akdeniz, Nadiye; Kepenek, Ferat; Gundogan, Cihan
    ObjectiveThe aim of this study was to determine the prognostic role of volumetric parameters and Pro-PET scores obtained from (68) Ga-prostate-specific membrane antigen (PSMA) PET/CT and F-18-FDG PET/CT in patients with metastatic castration-resistant prostate cancer (mCRPC) receiving taxane therapy.Materials and methodsThe study included 71 patients who underwent simultaneous PSMA and F-18-FDG PET/CT imaging between January 2019 and January 2022, had a Pro-PET score of 3-5 and had received taxane therapy after imaging. F-18-FDG tumor volume (TV-F) and PSMA tumor volume (TV-P) values of the lesions and total lesion glycolysis (TL-G) and total lesion PSMA (TL-P) values of the lesions were calculated on both imaging studies and the effects of these parameters on overall survival (OS) were investigated.ResultsThe median age of the patients included herein was 71 years (56-89) and the median prostate-specific antigen (PSA) level was 16.4 (0.01-1852 ng/dL). According to the Kaplan-Meier survival analysis, TTV-P >= 78.5, TTL-P >= 278.8, TTV-F >= 94.98, TTL-G >= 458.3, TTV-P + F >= 195.45, TTL-G + P >= 855.78, lymph node (L)TV-FDG >= 3.4, LFDG-SUVmax >= 3.2, LFDG-SUVmean >= 2.25, LFDG-SUVpeak >= 2.55, and bone (B)TV-F >= 51.15 values were found to be prognostic factors in predicting short OS. Multivariate Cox regression analysis showed that a Vscore >= 3 (95% confidence interval [CI]: 7.069-98.251, p < 0.001) and TTL-G + P >= 855.78 (95% CI: 4.878-1037.860, p = 0.006) were found to be independent prognostic factors in predicting short OS.ConclusionVolumetric parameters and Pro-PET scores obtained from (68) Ga-PSMA PET/CT and F-18-FDG PET/CT imaging have been shown to have an impact on OS in patients with mCRPC receiving taxane therapy.
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    Superiority of 18F-FDG PET/CT to 68GA-FAPI PET/CT in Adrenocortical Tumor Imaging
    (Lippincott Williams & Wilkins, 2023) Kaplan, Ihsan; Can, Canan; Kepenek, Ferat; Ibiloglu, Ibrahim; Guzel, Yunus
    F-18-FDG PET/CT was performed to evaluate the response to treatment in a 62-year-old female patient who was operated for adrenocortical carcinoma. High FDG uptake was observed in recurrent lesion in the left adrenal gland site and metastatic lesions. In the Ga-68-FAPI-04 PET/CT study, low FAPI uptake was observed in both recurrences and metastases. In this case, we demonstrated the superiority of F-18-FDG PET/CT over Ga-68-FAPI-04 PET/CT in the evaluation of adrenocortical carcinoma.