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    Antioxidative effects of alpha-lipoic acid in spinal cord injury an experimental rat model
    (Edizioni Luigi Pozzi, 2021) Ercan S.; Aktaş A.; Kemaloglu M.S.
    BACKGROUND: Traumatic and ischemic injuries of the spinal cord are effective in the development of neurological dysfunction of tissue damage caused by primary and secondary mechanisms. Free radical changes are effective in the development of early ischemia and progressive tissue ischemia is the main cause of secondary damage. Delaying ischemia is the basis of treatment. In this study, we aimed to demonstrate the presence of neuroprotective effects of alpha-lipoic acid in comparison with methylprednisolone. METHODS: 50 Sprague Dawley rats were divided into 5 groups (n = 10) and spinal cord trauma was created by the method, described by Rivlin and Tator. Group 1: Laminectomy group, Group 2: Laminectomy + spinal cord injury (SCI), Group 3: Laminectomy + SCI + alpha-lipoic acid (ALA) (100 mg / kg), Group 4: Laminectomy + SCl + Methyl-prednisolone (30 mg / kg), Group 5: Laminectomy + SCl + ALA + Methyl-prednisolone. RESULTS AND DISCUSSION: Rats with spinal cord injury were found to be paraplegic. There was no significant change in motor function between the groups. When the antioxidant values were compared in the groups, there was a statistically significant difference between Group 2 and Group 3. Oxygen radicals decreased significantly between ALA and Methylprednisolone. The most striking difference was between the monotherapy group and the combined treatment group. CONCLUSION: Our results showed that alpha lipoic acid given after spinal cord trauma in rats decreases anti-oxidant formation. © 2021, Edizioni Luigi Pozzi. All rights reserved.
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    Parafalxial empyemas (two cases)
    (1995) Erdam H.; Ozkan U.; Kemaloglu M.S.
    Intracranial infections can locate at anywhere in the brain. Subdural empyemas are the less common type of intracranial infections, and parafalxial localization is seen rare. Findings of intracranial pressure increase developed in a cases who were treated for purulent meningitis. Parafalxial empyemas were diagnosed in succeeding cranial computed tomography. Middle line was drained by means of craniotomy or burrhole. We reported two cases who recovered without any postoperative sequel considered the rare localization site of infection.