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    Anesthesia dolorosa caused by penetrating cranial injury
    (Karger, 2006) Tatli, Mehmet; Keklikci, Ugur; Aluclu, Ufuk; Akdeniz, Sedat
    Anesthesia dolorosa (AD) is an uncommon complication of surgical treatments for trigeminal neuralgia. Its incidence is around 0.8%. To our best knowledge, AD caused by a penetrating cranial injury has not been reported previously. We report the case of a 31-year-old male patient with left-sided neuropathic keratitis and AD that began 18 years earlier, following a penetrating cranial injury with a knife to the left postauricular area. The patient was successfully treated by a carbamazepine and gabapentin combination. In conclusion, penetrating cranial injury is uncommon but may cause a serious neurologic disturbance. In the differential diagnosis of AD, a penetrating injury should be kept in mind. In these cases, treatments should be effective and immediate; otherwise, this may result in catastrophic consequences such as neurotrophic keratitis and blindness. Ophthalmologists should be aware of these potential problems. Copyright (c) 2006 S. Karger AG, Basel.
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    Automated quantification of foveal avascular zone and vascular density in Behcet's disease
    (Springer London Ltd, 2020) Turkcu, Fatih Mehmet; Sahin, Alparslan; Karaalp, Umit; Cinar, Yasin; Sahin, Muhammed; Ozkurt, Zeynep Gursel; Keklikci, Ugur
    PurposeTo measure the vascular density (VD) and foveal avascular zone (FAZ) area in patients with Behcet's disease (BD) obtained by optical coherence tomography angiography (OCTA).MethodsVD and FAZ area in the deep and superficial retinal vascular networks were measured in all eyes.ResultsThirty BD and 31 control subjects were included in the study. The mean overall VD measured in the entire scan was lower in BD compared with control group in both the superficial (49.526.54 vs 53.57 +/- 2.87%, respectively; p=0.003) and deep (53.44 +/- 7.44 vs 58.41 +/- 3.01%, respectively; p=0.002) areas. The FAZ in the BD group was significantly increased at the level of the superficial (0.52 +/- 0.67 vs 0.28 +/- 0.1 mm(2), respectively; p=0.05) and deep (0.91 +/- 1.25 vs 0.39 +/- 0.14 mm(2), respectively; p=0.024) areas compared with those of the control group. The deep and the superficial FAZ areas were positively correlated with disease duration and negatively with VA.Conclusionp id=ParIn the patients with BD, OCTA showed decreased VD in both the superficial and deep retinal vascular networks. Besides, the VA was correlated with the VD and FAZ.
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    Central Retinal Vein Occlusion Associated with Hyperhomocysteinemia in a Patient with Heterozygous for the Methylenetetrahydrofolate Reductase C677T Mutation: Case Report
    (Ortadogu Ad Pres & Publ Co, 2012) Sakalar, Y. Bayezit; Keklikci, Ugur; Unlu, Kaan; Caca, Ihsan; Alakus, Mehmet Fuat
    A 19-year-old male patient presented with blurring of vision in his left eye. Central retinal vein occlusion was detected on ophthalmic examination. Clinical examination and laboratory analysis were performed for risk factors predisposing him to retinal vein occlusion. His plasma homocysteine concentration was 14.30 U/mL. No other abnormalities were found in other hematologic tests. C677T heterozygous mutation in the methylenetetrahydrofolate reductase (MTHFR) gene was detected by real-time polymerase chain reaction. A heterozygous mutation was detected in the same gene in the patient's mother, father and one of his sisters, also a homozygous mutation was detected in the other sister. Retinal vein occlusion in young patients may be related to mild hyperhomocysteinemia and a C677T mutation in the MTHFR gene.
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    Comparison of Different Methods for Measurement of Intraocular Pressure and Evaluation of Effect of Central Corneal Thickness on Measurement Results
    (Turkish Ophthalmological Soc, 2010) Sakalar, Yildirim Bayezit; Keklikci, Ugur; Balsak, Selahattin; Dogan, Eyyup; Unlu, Kaan
    Purpose: To compare measurements of intraocular pressure (IOP) by Goldmann applanation tonometer ( GAT), tonopen and non-contact tonometer (NCT) in normal eyes, and determine the relationship between the results of IOP measurement and central corneal thickness (CCT). Material and Method: Seventy-nine eyes of 41 patients, whose ophthalmologic examination and visual field test revealed no glaucoma, were included into the study. IOP was measured by GAT, NCT and tonopen. CCT was measured with an ultrasonic pachymeter. Results: The mean IOP measured by GAT was 12.63 +/- 2.94 mmHg, by tonopen - 8.51 +/- 2.66 mmHg and by NCT - 13.34 +/- 3.88 mmHg. In terms of measurement results, there was a statistically significant difference between the three methods (p<0.05). Although the correlation between tonopen and CCT was insignificant (p>0.05), there was a significant correlation between GAT and CCT, as well as between NCT and CCT (p<0.05). Discussion: There was a significant difference between measurements of IOP by GAT, NCT and tonopen in normal eyes. Tonopen may not be affected by CCT in normal eyes, while a significant correlation existed between CCT and GAT or NCT in normal eyes.
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    A comparison of latanoprost monotherapy with a combination therapy of timolol/dorzolamide in patients with primary open-angle glaucoma
    (Amer Soc Contemporary Medicine Surgery & Ophthalmology, 2006) Caca, Ihsan; Simsek, Hueseyin; Uenlue, Kaan; Ari, Seyhmus; Keklikci, Ugur
    We compared latanoprost monotherapy therapy with timolol/dorzolamide in patients with primary open-angle glaucoma to evaluate the effects on intraocular pressure (IOP) and occurrence of adverse events. IOP and topical side, effects were evaluated at the begining, first, and third months. Mean IOP was decreased at the third month. The most common side effect was hyperemia (43.6%). We Concluded that latanoprost reduces IOP better than fixed combination and its topical side effects are tolerable.
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    Congenital isolate and total optic disc coloboma -: Case report and review of the literature
    (Humana Press Inc, 2007) Ari, Seyhmus; Keklikci, Ugur; Caca, Ihsan; Unlu, Kaan; Alakus, Fuat
    Isolated and total optic disc coloboma is a markedly rare congenital anomaly of the eye. Congenital eye colobomas frequently present with eye anomalies and systemic signal findings. We present a case of isolated total optic disc coloboma without systemic involvement, which has been rarely reported in the literature.
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    Conjunctival impression cytology in patients with ectodermal dysplasia
    (Galenos Yayincilik, 2012) Soker, Sevda; Keklikci, Ugur; Mese, Ayse; Akkus, Murat; Nergiz, Yusuf
    Ectodermal dysplasia is a group of symptoms affecting tissues and organs of ectodermal origin. In this study, conjunctival impression cytology technique which is a non-invasive method was performed in patients with ectodermal dysplasia to evaluate the affects on conjunctiva. Six eyes of three patients with ectodermal dysplasia who were followed up by the Ophthalmology Clinic of Dicle University Faculty of Medicine and Prosthetic Dentistry Departments were included in the study. Bulbar conjunctiva impression cytology method was applied to the upper surface of the bulbar conjunctiva and the cell groups taken to the surface of cellulose acetate paper were fixed by a solution containing 70% ethyl alcohol, 37% formaldehyde and glicial acetic acid with a ratio of 20:1:1 and later stained by periodic acid-schiff and haematoxylin-eosin. Using impression cytology method a decrease in integrity of the cells, picnotic changes in the nucleus, epithelial cell-like changes and loss of goblet cells were observed in patients with ectodermal dysplasia. The findings of eye dryness in patients with ectodermal dysplasia were supported by the impression cytology technique. Impression cytology can be used as a non-invasive method in ophthalmologic follow-up of patients with ectodermal dysplasia. (Turk Arch Ped 2012; 47: 69-72)
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    Conjunctival-limbal autograft, amniotic membrane transplantation, and Intraoperative mitomycin C for primary pterygium
    (Humana Press Inc, 2007) Keklikci, Ugur; Celik, Yusuf; Cakmak, Sevin Soker; Unlu, M. Kaan; Bilek, Bagdagul
    We evaluated and compared the safety and efficacy of the conjunctival-limbal autograft, amniotic membrane transplantation, and intraoperative application of mitomycin C in 94 patients undergoing primary pterygium surgery and concluded that conjunctival-limbal autografting and amniotic membrane methods were more effective and safer than intraoperative mitomycin C.
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    Distribution of Central Corneal Thickness and Intraocular Pressure in a Large Population of Turkish School Children
    (Informa Healthcare, 2012) Sakalar, Yildirim Bayezit; Keklikci, Ugur; Unlu, Kaan; Alakus, Mehmet Fuat; Yildirim, Mine; Dag, Umut
    Purpose: To determine the distribution of central corneal thickness (CCT) and intraocular pressure (IOP) in a population of Turkish school children and to evaluate the relationships between these values and both age and gender. Methods: A total of 30,320 eyes from 15,160 healthy school children aged 5-18 years were examined. CCT and IOP were measured using an ultrasonic pachymeter and a non-contact tonometer, respectively. Measurements were compared with age, gender, and parental consanguinity of subjects. Results: The mean age of the school children was 10.43 +/- 2.54 years. For right eyes, mean CCT was 557.91 +/- 34.26 mu m and mean IOP was 14.15 +/- 2.87 mmHg. Mean CCT was significantly thicker in males compared to females (P < 0.0001). Mean IOP was significantly higher in females compared to males (P < 0.0001). CCT in children aged 14 years and older was significantly thinner than that in the younger age groups (P < 0.0001). There was a significant difference among the age groups for IOP (P < 0.05). No significant differences were observed in CCT or IOP related to parental consanguinity (P = 0.538, P = 0.319, respectively). Conclusion: Mean CCT in Turkish school children is of comparable thickness to that in Western school children. CCT reached adult values around 14 years of age in our children. Furthermore, males had thicker CCT than females. IOP was lower in males than females, and increased with age.
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    The effect of extremely low frequency magnetic field on the conjunctiva and goblet cells
    (Taylor & Francis Inc, 2008) Keklikci, Ugur; Akpolat, Veysi; Ozekinci, Selver; Unlu, Kaan; Celik, M. Salih
    Purpose: The aim of this study was to examine the effects of extremely low frequency magnetic field (ELF MF) on the conjunctiva and goblet cells density. Methods: Thirty adult female Spraque Dawley rats were assigned to one of two groups, each containing 15 rats. The experimental group received magnetic field 4 hr/day for 7 days. The second group received standard laboratory care and served as a control. The specimens were evaluated by light microscopy for goblet cell density, conjunctival edema, inflammation, and fibroblast proliferation. Results: In ELF MF exposure group rats, the number of goblet cells was less than the control group. We also observed a significant difference between ELF MF exposure group and control group in terms of goblet cell density (p = 0.010). The ELF MF exposure group manifested conjunctival edema and inflammation compared to the control group (p < 0.001 and p = 0.003). There was no statistical difference between the groups for fibroblast proliferation (p = 0.422). Conclusion: This study suggests that ELF MF exposure leads to morphological alterations of the conjunctiva and reductions in the number of goblet cells. We believe that ELF MF may cause dry eye symptoms.
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    The effectiveness of automatic pupillometry as a screening method to detect diabetic autonomic neuropathy
    (Springer, 2020) Erdem, Seyfettin; Karahan, Mine; Ava, Sedat; Pekkolay, Zafer; Demirtas, Atilim Armagan; Keklikci, Ugur
    Purpose This study aimed to compare static and dynamic pupil responses of diabetic patients with and without nonproliferative diabetic retinopathy (DR) and normal healthy individuals under different lighting conditions via quantitative automated pupillometry. Methods Forty patients with DM with nonproliferative DR (group 1), 40 patients with DM without DR (group 2), and 40 healthy controls (group 3) underwent a complete ophthalmologic examination. Static pupillometry [scotopic pupil diameter (PD), mesopic PD, low photopic PD, and high photopic PD] and dynamic pupillometry (resting PD, contraction amplitude, latency, duration, velocity of contraction, dilatation latency, and duration and velocity at rest) were measured via automatic quantitative pupillometry. Results Analysis of variance revealed that scotopic PD [F(2, 117) = 6.42;p = 0.02], mesopic PD [F(2, 117) = 3.20;p = 0.04], and low photopic PD [F(2, 117) = 4.86;p = 0.009] were significantly different among the groups. Scotopic PD and low photopic PD were significantly lower in group 1 than in group 2 (p = 0.03 andp = 0.03, respectively). Meanwhile, the resting diameter, velocity of pupil contraction, and velocity of pupil dilatation were found to be significantly lower (p = 0.02,p = 0.01, andp = 0.008, respectively), and the duration of pupil contraction was significantly higher in group 1 than in group 3 (p = 0.03). Conclusion Both DM patients with and without nonproliferative DR exhibited pupillary involvement. Automated pupillometry may be an easily applicable, noninvasive screening option for reducing mortality and morbidity rates associated with diabetic autonomic neuropathy.
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    The effects of Aflibercept and Ranibizumab in patients with wet-type age-related macula degeneration
    (Reial Acad Medicina Illes Balears, 2025) Vural, Selahattin; Ava, Sedat; Polat, Ferhat Baver; Keklikci, Ugur
    Background and objective: This study aims to compare the effects of two different anti-VEGF drugs, aflibercept and ranibizumab, on OCT findings in patients with AMD. Materials and methods: We reviewed the medical records of patients diagnosed with wet type AMD between 2013-2020, who were treated with intravitreal ranibizumab or aflibercept, and had a minimum follow-up period of six months. Results: Aflibercept was injected into 50 eyes and ranibizumab was injected into 53 eyes. In best corrected visual acuity (BCVA) measurements, aflibercept was found to be superior especially at 1 month (p=0.003), and no difference was found in BCVA at 6 months (p=0.233). A negative correlation was found between BCVA measurements and SFC measurements at 1 month (r=-0.322, p=0.001). In the comparison of aflibercept and ranibizumab at 6 months; Aflibercept was found to be more effective than ranibizumab in reducing CFT (p=0.014). However, no statistically significant difference was found between aflibercept and ranibizumab in horizontal PED, vertical PED, HRD, IRC, SRF, ERM, ELM, ISOS, and CNVM measurements (p=0.119; p=0.220; p=0.167; p=0.531; p=0.351; p=0.844; p=0.768; p=0.944; p=0.703, respectively). Conclusions: Intravitreal aflibercept and ranibizumab injections in wet AMD patients were found to have similar effects on other OCT findings except for CFT. Studies with long follow-up and large series on this subject will provide more information.
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    Effects of Photodynamic Therapy With Verteporfin for the Treatment of Chronic Central Serous Chorioretinopathy: An Uncontrolled, Open-Label, Observational Study
    (Elsevier, 2010) Sakalar, Yildirim Bayezit; Keklikci, Ugur; Unlu, Kaan; Alakus, Mehmet Fuat; Kara, Ismail Hamdi
    BACKGROUND: Central serous chorioretinopathy is an idiopathic disorder that leads to serous neurosensory retinal detachment. The disorder is usually self-limited and resolves spontaneously; however, sometimes neurosensory retinal detachment persists. This form of the disorder is called chronic central serous chorioretinopathy (CCSC). OBJECTIVE: The aim of this study was to assess the effects of photodynamic therapy (PDT) on visual acuity with full-dose verteporfin for CCSC. METHODS: The eyes of patients with CCSC were included in the study. Ophthalmic examination including best-corrected visual acuity (BCVA), fundus examination, fluorescein angiography, and optical coherence tomography was performed before treatment and at 1, 3, 6, 9, and 12 months. PDT with full-dose verteporfin (6 mg/m(2) of body surface area) was applied only to areas of active leakage. BCVA was converted to a log of the minimum angle of resolution (logMAR) equivalent for statistical analysis. Central foveal thickness and BCVA between baseline and follow-up were compared. RESULTS: Seventeen eyes of 16 patients (13 males, 3 females; mean [SD] age, 39.75 [7.51] years; mean duration of follow-up, 13.06 [1.82] months) were used in the study. The mean (SEM) logMAR BCVA was 0.26 (0.07) at baseline and 0.04 (0.02) at 12 months. Mean logMAR BCVA values at baseline (0.259) and after treatment (0.112, 0.053, 0.047, 0.041, and 0.041 at 1, 3, 6, 9, and 12 months, respectively) differed significantly (P = 0.006, P = 0.005, P = 0.005, P = 0.005, and P = 0.005). There was a significant difference in the mean central foveal thickness at the final visit (169 pm) compared with the baseline value (383 pm; P < 0.001). BCVA decreased in one eye (20/20 vs 20/25) and persisted during follow-up; in the other 16 eyes, BCVA either increased (n = 10) or remained stable (n = 6). CONCLUSIONS: In this small, open-label study, patients with CCSC treated with a single course of PDT with full-dose verteporfin had significant improvement from baseline in BCVA and resolution of subretinal fluid accumulation and active leakage. Treatment was generally well tolerated, but one patient had worsening in BCVA. (Curr Thor Res Clin Exp. 2010;71:173-185) (C) 2010 Excerpta Medica Inc.
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    Efficacy of topical cyclosporin A 0.05% in conjunctival impression cytology specimens and clinical findings of severe vernal keratoconjunctivitis in children
    (Springer Tokyo, 2008) Keklikci, Ugur; Soker, Sevda I.; Sakalar, Yildirim B.; Unlu, Kaan; Ozekinci, Selver; Tunik, Selcuk
    To evaluate the efficacy of topical cyclosporin A 0.05% in managing the symptoms of severe vernal keratoconjunctivitis (VKC). Fifty-four children with severe VKC were included in this study. All 54 patients were treated with topical cyclosporin A (CsA) 0.05% for 3 months. Ocular signs and symptoms were scored in all patients at entry and after 3 months. Conjunctival impression cytology specimens were examined on the day of enrollment and at the end of the treatment period. The mean scores for severity of signs and symptoms significantly decreased after 3 months compared with those at entry (P < 0.001). The density of inflammatory cells in the conjunctival impression cytology specimens decreased significantly. No side effects of the treatment with CsA 0.05% eyedrops were observed. Topical CsA 0.05% eyedrops were found to be safe and effective in the treatment of patients with VKC. Consistent with these results, topical CsA may efficiently reduce conjunctival inflammation in severe VKC.
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    Evaluation of Diurnal Fluctuation in Parafoveal and Peripapillary Vascular Density Using Optical Coherence Tomography Angiography in Patients with Exfoliative Glaucoma and Primary Open-Angle Glaucoma
    (Taylor & Francis Inc, 2021) Demirtas, Atilim Armagan; Karahan, Mine; Ava, Sedat; Cilem Han, Cagla; Keklikci, Ugur
    Purpose To determine the diurnal variations in parafoveal and peripapillary vessel density using optical coherence tomography angiography in patients with exfoliative glaucoma, patients with primary open-angle glaucoma and healthy individuals. Materials and Methods In this prospective cross-sectional study, 36 exfoliative glaucoma patients, 34 primary open-angle glaucoma patients and 35 healthy individuals were examined. Optical coherence tomography angiography was used for examining the vessel density of peripapillary (radial peripapillary capillary) and parafoveal (superficial layer) regions. Optical coherence tomography angiography readings were obtained at 09:00, 11:00, 14:00 and 16:00 on the same day. Intraocular pressure values were assessed accordingly. The intraclass correlation coefficients were used to evaluate test-retest variability. Results Diurnal variation in intraocular pressure or vessel density values was not found in any parafoveal or peripapillary region in any of the groups at any hour of measurement. The vessel density in the temporal sector of the exfoliative glaucoma group was significantly lower than in the primary open-angle glaucoma group at all time points. (Mann-Whitney U test; 09:00,P= .015; 11:00,P= .002; 14:00,P= .040; and 16:00,P= .048, respectively). The test-retest repeatability was high and almost excellent for the parafoveal and peripapillary regions in each group (XFG range: 0.757 - 0.985, POAG range: 0.834 - 0.985, and control range: 0.708 - 0.983). Conclusions It may be important to estimate the diurnal fluctuation occurring in retinal haemodynamics in patients with exfoliative glaucoma and primary open-angle glaucoma despite the lack of any considerable variation in intraocular pressure and retinal vessel density values in one day. The study found that at any point of time, vessel density of radial peripapillary capillary in temporal region was lower in exfoliative glaucoma patients than in primary open-angle glaucoma patients having the same glaucoma severity.
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    Evaluation of parafoveal vascular density using optical coherence tomography angiography in patients with central serous chorioretinopathy
    (Springer London Ltd, 2022) Dursun, Mehmet Emin; Erdem, Seyfettin; Karahan, Mine; Ava, Sedat; Hazar, Leyla; Dursun, Birgul; Keklikci, Ugur
    Using optical coherence tomography angiography (OCTA), we sought to evaluate parafoveal vascular density (VD) in patients with central serous chorioretinopathy (CSCR). Our study included 43 patients with a diagnosis of CSCR and 40 healthy controls. Ophthalmologic examination findings and OCTA measurements of the participants were retrospectively analysed. Of the 43 patients with CSCR, 31 were males (72%) and 12 were females (28%); the control group was 30 males (75%) and 10 females (25%) (p = 0.657). There were significant differences between affected eyes, unaffected eyes and healthy control eyes for all parameters in the superficial capillary plexus (SCP) VD and deep capillary plexus (DCP) VD (p < 0.05 for all values). It was also determined that the affected eyes had lower SCP-VD and DCP-VD than the unaffected eyes and that the unaffected eyes had lower SCP-VD and DCP-VD than the healthy control eyes (p < 0.05 for all values). While there were no significant differences in the deep foveal avascular zone (FAZ) area, the superficial FAZ area was larger in affected eyes than in both unaffected eyes and healthy control eyes (p < 0.05). In most areas, the SCP-VD and DCP-VD values were lower and the FAZ larger in the chronic group than in the acute group (p < 0.05). Retinal vascular changes were found in patients with both acute and chronic CSCR, and the fellow eyes of these patients were also affected. OCTA can therefore be considered an easily applicable, non-invasive screening option for evaluating the microvascular structure in these patients.
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    Evaluation of Perforating Eye Injuries by Using Cluster Analysis
    (Amer Soc Contemporary Medicine Surgery & Ophthalmology, 2008) Keklikci, Ugur; Celik, Yusuf; Cakmak, Sevin Soker; Sakalar, Yildirim B.; Unlu, M. Kaan
    We evaluated the epidemiology, visual outcome, and clinical characteristics of serious eye injuries and identified preventable risk factors. We concluded that many accidents and their resulting injuries were preventable by education, greater intensive care and workplace safety. Perforating ocular injuries in rural environment are still a big therapeutic, social and economic problem.
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    Glaucoma Associated with Trauma
    (Turkish Ophthalmological Soc, 2012) Keklikci, Ugur
    Glaucoma is a common in eyes with trauma. This condition results in significant elevations of intraocular pressure (IOP). Elevated IOP after ocular trauma can occur immediately after the injury, or at any time in the future, even years later. Thus, all cases with a history of significant ocular trauma require lifelong surveillance for the onset and progression of glaucoma. This review article discusses the various etiologies of traumatic glaucoma and its management.
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    The Importance of the Family Factory in Perforating Eye Injuries
    (Turkish Ophthalmological Soc, 2007) Keklikci, Ugur; Sakalar, Yildirim Bayezit; Unlu, Kaan; Bozarslan, Berivan Senol; Dag, Umut
    Background: To evaluate epidemiologic properties of infants applying to our clinic due to perforating eye injury, as well as the educational level of their parents, and socioeconomic status of their families. Methods: A total of 172 patients aged between 0-15 years and applying to our clinic due to perforating eye injury between March 2005 - March 2007, were included into the study. The cases were prospectively evaluated in terms of age, sex, material causing injury, cause of injury and social environtment where it occured, education levels and professions of parents, the number of siblings, socioeconomic and environmental conditions. Results: Of the cases, 117 (68%) were male, and 55 (32%) were female: the mean age of the patients was 7.8 +/- 5.6 (1-15 years old). The mothers of 118 cases (68.6%) and fathers of 52 cases (30.2%) were determined to be illiterate. Eye injuries occured mostly (53.5%) during playing activites. In 79.6% of the cases, the montly income per capita was less than 150 Yeni Turk Lirasi (YTL.), and 65% of the families had five or more siblings. In addition, 102 (59.3%) of our cases were living in rural areas. Conclusion: There was a significant relationship between perforating eye injuries and parents'educational level and socioeconomic status. It was concluded that this kind of injuries could be prevented through education of parents and improvent of socioeconomic conditions of families.
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    Incidence, clinical findings and management of intraoperative floppy iris syndrome associated with tamsulosin
    (Wiley-Blackwell Publishing, Inc, 2009) Keklikci, Ugur; Isen, Kenan; Unlu, Kaan; Celik, Yusuf; Karahan, Mine
    To determine the risk ratios and incidence of intraoperative floppy iris syndrome (IFIS) during cataract surgery in patients using tamsulosin, and to assess management strategies for IFIS. We performed a non-randomized, observational, prospective study, in which 594 eyes of 579 patients undergoing cataract surgery were enrolled. Surgeons were masked to the patients' drug history. Usage or non-usage of tamsulosin, duration of tamsulosin use, presence or absence of IFIS, management of IFIS and intraoperative complications were recorded in the patients' theatre notes. Twelve of 15 (80%) IFIS patients were taking systemic tamsulosin. Twelve of 23 (52%) patients using tamsulosin showed features of IFIS. The odds ratios (ORs) and relative risk (RR) ratios show strong positive correlations between tamsulosin use and IFIS. The ORs and RR ratios and the 95% confidence intervals (CIs) are as follows: OR 206.5 (95% CI 50.9-836.5); RR 99.3 (95% CI 30.0-327.8). There were no statistically significant differences between patients with or without IFIS, who were using tamsulosin, in terms of age or duration of tamsulosin use (p > 0.05). Seven eyes (46.6%) with IFIS were successfully managed with epinephrine. Eight eyes (53.4%) with IFIS needed iris hooks. Patients using tamsulosin appear to be at high risk of IFIS during cataract surgery. The occurrence of IFIS may not be affected by duration of tamsulosin use or age. Epinephrine may be effective in approximately 50% of eyes with IFIS. The iris hook procedure represents an effective management strategy in IFIS.